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Basic study of heavy-ion irradiated to the normal brain tissue -Effects of carbon particles exposure to rat's hypothalamus on the spontaneous motor activity-

重离子照射正常脑组织的基础研究-碳粒子照射大鼠下丘脑对自发运动活动的影响-

基本信息

批准号：
17591249
负责人：
UNO Takashi
金额：
$ 2.24万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

Radiation therapy is applied to several brain tumors. It is expected that irradiation to the brain, especially in younger age, gives some adverse effects. Heavy-ion beams are more effective to treat brain tumors than ordinary X-rays. However, the effect of heavy-ion irradiation to brain on spontaneous motor activity is not reported. This study was designed to determine whether irradiation (carbon particles 290 MeV/nucleon, mono peak 60Gy, irradiation field 5 mm^2 in midbrain) to rat's hypothalamus modifies the spontaneous motor activity of male rats.The irradiation field in rat's brain after carbon particles irradiation was identified by imaging plate method. The spontaneous motor activity was determined with the wheel-running test. The activity was measured using an active increase effect of methamphetamine (MAP). The observation of wheel-running activity was conducted for 90 min after 2, 6, 14, 22, 26 or 30 weeks following irradiation.Results are as follows.The control group and irradiated group were highest motor activity in wheel-running test at first test ( 1^<st> injection of MAP, 2 weeks after irradiation) ; however, motor activity of the control group decreased after from 2^<nd> test (6 weeks) to 5^<th> test (22 weeks). On the other hand, 60 Gy exposed rats were not decrement of wheel-running activity which depended on number of times in motor activity test (injection time of MAP). These results may be possible to describe that carbon irradiation to hypothalamus is caused edema at the irradiated field. Furthermore, it was supposed that an ambient blood flow increased to make up for disordered hemodynamics by the edema.

放射治疗被应用于几种脑瘤。预计对大脑的辐射，特别是在较年轻的时候，会产生一些不良影响。重离子束治疗脑瘤比普通X射线更有效。然而，重离子照射脑内对自发运动活动的影响尚未见报道。本研究旨在探讨大鼠下丘脑照射(碳粒子290 MeV/核子，单峰60Gy，中脑照射野5 mm^2)对雄性大鼠自发运动活动的影响。用跑轮试验测定大鼠自发运动活动。用甲基苯丙胺(MAP)的主动升高效应测定其活性。分别于照射后2、6、14、22、26、30周进行90min的车轮行走活动观察，结果如下：第一次试验(照射后2周注射MAP)，对照组和照射组在车轮行走试验中运动活动度最高，而对照组运动活动度从第2周试验(6周)下降至第5周(22周)。而60Gy线照射大鼠在运动试验(MAP注射时间)中并未表现出随运动次数增加而减少的跑轮活动。这些结果可能描述了对下丘脑的碳射线照射是由照射野的水肿引起的。此外，据推测，周围血流量增加，以弥补因浮肿而造成的血流动力学紊乱。