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Quantitative assessment of myocardial perfusion and viability with contrast enhanced MRI

对比增强 MRI 定量评估心肌灌注和活力

基本信息

批准号：
15591265
负责人：
SAKUMA Hajime
金额：
$ 2.18万
依托单位：
Mie University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591265/
关键词：
Heart MRI Gd-DTPA Myocardial perfusion Myocardial infarction Angina pectoris Myocardial viability magnetic resonance imaging 造影剤 Magnetic Resonance Imageing 造血剤

项目摘要

In the current study, we continued our research on quantitative assessment of first-pass contrast enhanced myocardial perfusion MRI and evaluation of extent of infracted myocardium in patient with myocardial infarction. Clinical studies on myocardial perfusion MRI indicated that improvement of the MR pulse sequence is required to reduce subendocardial artifacts caused by cardiac contraction and suboptimal spatial resolution. Consequently, the ECG gated acquisition delay time of myocardial perfusion MRI in the cardiac cycle was optimized so that MR image datasets can be obtained during the systolic and diastolic rest periods of the heart. In addition, spatial resolution of myocardial perfusion MRI was improved to less than 2mm by using a parallel imaging method. As for the quantitative analysis of myocardial perfusion, we have improved the methods of blood saturation correction, baseline detection of blood and myocardial time-intensity curves, automated determination of fitting range fo … More r Patlak lot analysis. With these improvements, distribution myocardial blood flow can be accurately determined with improved reproducibility and reduced statistical variation. As for the assessment of delayed enhanced MRI, we optimized 3D delayed enhanced MR image acquisition by using a parallel imaging method and improved an algorithm to demonstrate three dimensional distribution and transmural extent of myocardial infarction. In the preliminary clinical studies, we performed (1) quantitative assessment of myocardial flow parameter, K1, for the entire left ventricular myocardium by using a Patlak lot method, (2) Quantification of myocardial blood flow by correcting K1 value with extraction fraction of Gd-DTPA, (3) assessment of myocardial perfusion reserve by analyzing rest and ATP-stress myocardial perfusion MRI, and (4) evaluation of myocardial blood flow and myocardial perfusion reserve in epicardial and endocardial myocardial layers. These approaches were used for determining the pathophysiology of ischemic heart disease and hypertrophic cardiomyopathies. Less

在本研究中，我们继续研究首次通过增强心肌灌注MRI的定量评估和评价心肌梗死患者的梗死心肌范围。心肌灌注MRI的临床研究表明，需要改进MR脉冲序列，以减少心脏收缩和次优空间分辨率引起的内膜下伪影。因此，优化了心动周期中心肌灌注MRI的ECG门控采集延迟时间，从而可以在心脏的收缩期和舒张期休息期间获得MR图像数据集。此外，通过采用并行成像方法，心肌灌注MRI的空间分辨率提高到2 mm以下。在心肌灌注定量分析方面，我们改进了血液饱和度校正、血液和心肌时间-强度曲线基线检测、拟合范围自动确定、心肌血流灌注定量分析等方法。 ...更多信息 r Patlak批次分析。通过这些改进，可以以改进的再现性和减少的统计变化准确地确定分布心肌血流量。在延迟增强MRI的评价方面，我们采用并行成像方法优化了3D延迟增强MR图像采集，并改进了显示心肌梗死三维分布和透壁范围的算法。在初步临床研究中，我们进行了（1）使用Patlak lot方法定量评估整个左心室心肌的心肌血流参数K1，（2）通过Gd-DTPA提取分数校正K1值来定量心肌血流量，（3）通过分析静息和ATP-负荷心肌灌注MRI来评估心肌灌注储备，（4）评价心外膜和心内膜心肌层的心肌血流和心肌灌注储备。这些方法用于确定缺血性心脏病和肥厚性心肌病的病理生理学。少