Prediction of aggressiveness of prostate cancer using MR spectroscopy at ultra-high magnetic field

2003年，5例经活检证实的前列腺癌患者被纳入本研究。使用3特斯拉MR单元获得MR图像和MR谱。在5例患者中，4例由于活检后前列腺出血导致质量差而无法评估频谱，需要消除直肠气体和前列腺出血以保持磁场均匀性。2004年的研究在前列腺活检前进行MR检查，并在MR检查前一天使用泻药，51例患者中有25例（50%）获得了高质量的频谱。据推测，成功率低的原因之一是整个前列腺的射频（RF）激励不均匀。在25例患者中，在光谱采集后计算（胆碱+肌酸）/柠檬酸盐峰面积比（CC/C）。外周带癌的平均CC/C为1.94，健康PZ为0.46（p<0.0001）。在移行区（TZ），癌症患者CC/C平均为1.84，健康TZ为1.03。本研究的局限性是检查成功率低，但在1.5 T时，成功激发的患者的频谱质量优于普通频谱，但仍有上级。当RF激发方法完全改进时，使用超高MR单元产生显著重要的代谢物信息。

In 2003, 5 patients with biopsy proved prostate cancer were included in this study. MR images and MR spectra were obtained using 3 tesla MR unit. In 4 of 5 patients, spectra could not be evaluated because of poor quality due to post-biopsy prostate hemorrhage.Elimination of rectal gas and prostate hemorrhage was needed to keep magnetic field homogeneity. MR examination was performed before prostate biopsy, and using a purgative the day before the MR examination in 2004 study.High quality spectra were obtained in 25 of 51 patients (50%). It was presumed that one of the reasons of low successful rate was inhomogeneous radiofrequency (RF) excitation of whole prostate. In 25 patients, the (choline + creatine) / citrate peak area ratio (CC/C) was calculated after spectroscopic acquisition. The mean CC/C was 1.94 in peripheral zone (PZ) cancer, and 0.46 in healthy PZ (p<0.0001). In transition zone (TZ), the mean CC/C was 1.84 in cancer, and 1.03 in healthy TZ.The limitation of this study was low successful examination rate, but the spectral quality in patient with successful RF excitation was superior to usual spectrum at 1.5 tesla. When the RF excitation method is improved completely, significantly important metabolite information is produced using ultra-high MR unit.