Prediction of aggressiveness of prostate cancer using MR spectroscopy at ultra-high magnetic field

使用超高磁场下的磁共振波谱预测前列腺癌的侵袭性

• 批准号: 15591275
• 负责人: KAJI Yasushi
• 金额: $ 2.18万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591275/
• 关键词: prostate cancer; ultra-high magnetic field; MR spectroscopy; MR spectroscopy; MRI

In 2003, 5 patients with biopsy proved prostate cancer were included in this study. MR images and MR spectra were obtained using 3 tesla MR unit. In 4 of 5 patients, spectra could not be evaluated because of poor quality due to post-biopsy prostate hemorrhage.Elimination of rectal gas and prostate hemorrhage was needed to keep magnetic field homogeneity. MR examination was performed before prostate biopsy, and using a purgative the day before the MR examination in 2004 study.High quality spectra were obtained in 25 of 51 patients (50%). It was presumed that one of the reasons of low successful rate was inhomogeneous radiofrequency (RF) excitation of whole prostate. In 25 patients, the (choline + creatine) / citrate peak area ratio (CC/C) was calculated after spectroscopic acquisition. The mean CC/C was 1.94 in peripheral zone (PZ) cancer, and 0.46 in healthy PZ (p<0.0001). In transition zone (TZ), the mean CC/C was 1.84 in cancer, and 1.03 in healthy TZ.The limitation of this study was low successful examination rate, but the spectral quality in patient with successful RF excitation was superior to usual spectrum at 1.5 tesla. When the RF excitation method is improved completely, significantly important metabolite information is produced using ultra-high MR unit.

2003年，5例经活检证实为前列腺癌的患者纳入本研究。使用3Tesla磁共振单元获得磁共振图像和磁共振波谱。在5名患者中，有4名患者由于活检后前列腺出血导致质量不佳而无法评估频谱。需要消除直肠气体和前列腺出血以保持磁场的均一性。在2004年的研究中，在前列腺活检前进行了MR检查，并在检查前一天使用了泻剂。51名患者中有25名(50%)获得了高质量的频谱。推测成功率低的原因之一是整个前列腺射频(RF)激发不均匀。25例患者在光谱采集后计算(胆碱+肌酸)/柠檬酸盐峰面积比(CC/C)。外周带癌的CC/C平均值为1.94，健康PZ组的CC/C平均值为0.46(p&lt；0.0001)。在过渡区(TZ)，癌症患者的CC/C平均值为1.84，健康TZ患者的CC/C平均值为1.03。本研究的局限性是检查成功率低，但成功射频激励的患者的频谱质量优于1.5Tesla的常规频谱。当完全改进RF激发方法时，利用超高MR单元产生重要的代谢物信息。