Development of prostate MR spectra analysis at high magnetic field for the purpose of evaluation of tumor aggressiveness

开发高磁场前列腺磁共振波谱分析以评估肿瘤侵袭性

• 批准号: 17591267
• 负责人: KAJI Yasushi
• 金额: $ 2.37万
• 依托单位: Dokkyo Medical University (2006)Kobe University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591267/
• 关键词: prostate cancer; citrate; MR spectroscopy

80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.

本研究纳入了80例前列腺癌患者。然而，我们可以比较29例患者的光谱数据和活检结果。前列腺癌患者的（胆碱+肌酸）/柠檬酸（CC/C）比值明显高于正常前列腺癌患者。CC/C比值与Gleason评分呈正相关（r=0.686）。高磁场下CC/C比值可预测肿瘤侵袭性。基于密度矩阵的光谱估计方法的发展使体内柠檬酸盐的t2弛豫时间的测量成为可能。为了了解光谱异常的位置和体积，开发了三维显示软件。该软件将为选择治疗方法提供重要信息。