Development of prostate MR spectra analysis at high magnetic field for the purpose of evaluation of tumor aggressiveness

本研究共纳入80例前列腺癌患者。然而，我们可以将29名患者的频谱数据与活检结果进行比较。(胆碱+肌酸)/柠檬酸(CC/C)比值(CC/C)在前列腺癌中显著高于正常前列腺癌。CC/C比值与Gleason评分显著相关(r=0.686)。在较高磁场下CC/C比值可以预测肿瘤的侵袭性，基于密度矩阵的谱估计方法的发展使测量体内柠檬酸盐的T2弛豫时间成为可能。为了了解光谱异常的位置和体积，开发了三维显示软件。该软件将为选择治疗方案提供重要信息。

80 patients with prostate cancer were included in this study. However, we could compare between spectra data and biopsy results in 29 patients. The (choline + creatine)/citrate (CC/C) ratio was significantly higher in cancer than in healthy prostate. CC/C ratio and Gleason score were correlated strongly (r=0.686). CC/C ratio at higher magnetic field may predict the tumor aggressiveness.Development of spectral estimation method based on density matrix made it possible to measure T2-relaxation time of in-vivo citrate. The three-dimensional display software was developed in order to understand the location and volume of spectral abnormalities. This software will offer the important information to select treatments.