Development of qualitative and quantitative analysis for pancreatic exocrine function : a novel approach using diffusion-weighted MR images

本研究的目的是无创性地观察和量化胰腺实质内水扩散的程度，评价胰腺不同部位的外分泌功能。首先，通过琼脂模体实验确定最佳的扩散加权成像参数。应用正常志愿者对所确定的基本成像参数进行修正，最终获得最佳的弥散加权成像参数。按照最初的计划，我们打算使用促胰液素，它刺激胰腺外分泌腺并增加胰腺含水量，以分别评价胰腺外分泌功能（头部、身体和尾部）。然而，促胰液素的销售被取消，促胰液素不能常规使用。我们没有进行临床试验，而是进行了有限的研究。我们评估了正常胰腺的扩散加权MRI之前和之后的促胰液素管理，我们库存。正如预期，观察到胰腺实质信号变化。这是证明， ...更多信息 艾德认为我们的假设是正确的，由于胰泌素的缺乏，我们放弃了单独评价胰腺外分泌功能，我们评价了弥散加权MRI上表观弥散系数（ADC）值的有用性。比较正常人与慢性胰腺炎患者胰腺实质ADC值的差异。结果表明，慢性胰腺炎的ADC值明显低于正常人。此外，我们观察到慢性胰腺炎的ADC值根据疾病的严重程度而降低，因此我们认为，使用本研究中确定的成像参数的弥散加权MRI不仅适用于胰腺，而且适用于其他区域。我们将我们的MRI方法应用于各种其他器官，如肾脏，子宫，卵巢，前列腺，并评估其疗效。因此，弥散加权MRI在鉴别这些器官的肿瘤性病变中发挥了重要作用。这一事实表明，我们的方法在各种病变的诊断中具有很大的潜力。少

The aim of this study was to visualize and quantify the degree of water diffusion in the pancreatic parenchyma and to evaluate exocrine function in different part of the pancreas non-invasively.First, optimal imaging parameters of diffusion-weighted MRI were determined by agar phantom experiment. Determined basic imaging parameters were modified by applying normal volunteers, then final optimal imaging parameters of diffusion-weighted MRI was obtained. By an original plan, we intend to use secretin, which stimulate exocrine pancreatic glands and increase pancreatic water content, in order to evaluate pancreatic exocrine function separately (head, body, and tail). However, sale of secretin was canceled and secretin could not be used routinely. Instead of clinical trial, we did a limited study. We evaluated diffusion-weighted MRI of the normal pancreas before and after administration of secretin which we stocked. As expected, pancreatic parenchymal signal change was observed. It was prov … More ed that our hypothesis was right.We gave up evaluating separate pancreatic exocrine function due to lack of secretin, then we evaluate the usefulness of apparent diffusion coefficiency (ADC) value on diffusion-weighted MRI. We compared ADC value of pancreatic parenchyma between normal volunteers and patients with chronic pancreatitis. The result showed that ADC values of chronic pancreatitis were significantly lower than those of normal volunteers. Furthermore, we observed that ADC values of chronic pancreatitis decreased according to disease severity.It is considered that diffusion-weighted MRI using imaging parameters we determined in this study was applied not only in the pancreas but also in other regions. We applied our MRI method to various other organs, such as kidney, uterus, ovary, prostate, and evaluated its efficacy. As a result, diffusion-weighted MRI played an important role in differentiating neoplastic lesions in those organs. This fact reveals that our method has a great potential in diagnosis of various lesions. Less