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Development of qualitative and quantitative analysis for pancreatic exocrine function : a novel approach using diffusion-weighted MR images

胰腺外分泌功能定性和定量分析的发展：一种使用扩散加权磁共振图像的新方法

基本信息

批准号：
15591283
负责人：
IRIE Hiroyuki
金额：
$ 1.98万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591283/
关键词：
Pancreas Exocrine function MRI Diffusion-weighted image 外分泌機能

项目摘要

The aim of this study was to visualize and quantify the degree of water diffusion in the pancreatic parenchyma and to evaluate exocrine function in different part of the pancreas non-invasively.First, optimal imaging parameters of diffusion-weighted MRI were determined by agar phantom experiment. Determined basic imaging parameters were modified by applying normal volunteers, then final optimal imaging parameters of diffusion-weighted MRI was obtained. By an original plan, we intend to use secretin, which stimulate exocrine pancreatic glands and increase pancreatic water content, in order to evaluate pancreatic exocrine function separately (head, body, and tail). However, sale of secretin was canceled and secretin could not be used routinely. Instead of clinical trial, we did a limited study. We evaluated diffusion-weighted MRI of the normal pancreas before and after administration of secretin which we stocked. As expected, pancreatic parenchymal signal change was observed. It was prov … More ed that our hypothesis was right.We gave up evaluating separate pancreatic exocrine function due to lack of secretin, then we evaluate the usefulness of apparent diffusion coefficiency (ADC) value on diffusion-weighted MRI. We compared ADC value of pancreatic parenchyma between normal volunteers and patients with chronic pancreatitis. The result showed that ADC values of chronic pancreatitis were significantly lower than those of normal volunteers. Furthermore, we observed that ADC values of chronic pancreatitis decreased according to disease severity.It is considered that diffusion-weighted MRI using imaging parameters we determined in this study was applied not only in the pancreas but also in other regions. We applied our MRI method to various other organs, such as kidney, uterus, ovary, prostate, and evaluated its efficacy. As a result, diffusion-weighted MRI played an important role in differentiating neoplastic lesions in those organs. This fact reveals that our method has a great potential in diagnosis of various lesions. Less

本研究的目的是可视化和量化胰腺实质中的水扩散程度，并无创地评估胰腺不同部位的外分泌功能。首先，通过琼脂体模实验确定扩散加权MRI的最佳成像参数。应用正常志愿者对确定的基本成像参数进行修改，得到最终的扩散加权MRI最佳成像参数。按照最初的计划，我们打算使用促胰液素，刺激胰腺外分泌腺并增加胰腺含水量，以分别评估胰腺外分泌功能（头、体、尾）。然而，促胰液素的销售被取消，促胰液素无法常规使用。我们没有进行临床试验，而是进行了有限的研究。我们在施用我们储备的促胰液素之前和之后评估了正常胰腺的弥散加权 MRI。正如预期的那样，观察到胰腺实质信号变化。事实证明，我们的假设是正确的。由于缺乏促胰液素，我们放弃了单独评估胰腺外分泌功能，然后我们评估了弥散加权 MRI 上的表观弥散系数（ADC）值的有用性。我们比较了正常志愿者和慢性胰腺炎患者胰腺实质的 ADC 值。结果显示，慢性胰腺炎的ADC值明显低于正常志愿者。此外，我们观察到慢性胰腺炎的ADC值根据疾病严重程度而降低。据认为，使用我们在本研究中确定的成像参数的扩散加权MRI不仅适用于胰腺，而且还适用于其他区域。我们将 MRI 方法应用于其他各种器官，如肾脏、子宫、卵巢、前列腺，并评估其功效。因此，弥散加权 MRI 在区分这些器官的肿瘤病变方面发挥了重要作用。这一事实表明我们的方法在诊断各种病变方面具有巨大的潜力。较少的