Quantitative evaluation of local biomechanics of thoracic aorta

胸主动脉局部生物力学的定量评价

• 批准号: 15591465
• 负责人: SAI Sadahiro
• 金额: $ 2.18万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591465/
• 关键词: Aortic aneurysm; Biomechanics; Intravascular ultrasound; Transesophageal echocardiography; Vascular wall; Tissue velocity; Macrophage; Inflammation; 超音波; ストレイン; 超音波組織性状診断

The objectives of the present study are to develop a quantitative measurement system of biomechanics of aortic wall by applying ultrasound diagnostics device and to establish an objective indication for rupture of aneurysm and operation. The concrete object of the research during grant-in-aid is to measure the local elasticity of aortic wall by using intravascular ultrasound (IVUS) and transesophageal echocardiography. (TEE)Radio-frequency (RF) signal of clinical IVUS apparatus was sampled via analogue/digital (A/D) converter with sampling rate of 500 MSa/s and stored in a workstation. Electrocardiogram and intracoronary pressure were also sampled via A/D converter with 10 kSa/s, simultaneously. The correlation and displacement of RF lines of the same address in neighboring flames were calculated. Assuming that high correlation area indicated vascular wall, automatic recognition of vascular wall was performed. Tissue velocity was calculated as the difference of the frames was 33 ms. Tissue Velocity Imaging was defined as the tissue velocity in high correlation areas. Short axis view of descending aorta was obtained by a TEE with the central frequency of 4-7 MHz. Electrocardiogram and blood pressure were recorded simultaneously. Two dimensional tissue velocity, vectors were calculated by template matching method of squared region of interests in neighboring frames. IVUS findings and excised specimen by directional coronary atherectomy were compared and TEE findings and surgicaly excised specimen were compared The passive movement by blood pressure variance was correlated with tissue components and expression of inflammatory cells such as macrophages. Finally, precise measurement of biomechanics by applying ultrasonic technology was shown in the present research.

本研究旨在应用超声诊断仪建立主动脉壁生物力学定量测量系统，为动脉瘤破裂及手术提供客观指征。研究的具体对象是利用血管内超声（IVUS）和经食管超声心动图测量主动脉壁的局部弹性。临床IVUS设备的TEE射频（RF）信号经A/D转换器以500 MSa/s的采样率采集并存储在工作站中。心电图和冠状动脉内压也通过A/D转换器以10 kSa/s同步采集。计算了相邻火焰中同一地址射频谱线的相关性和位移。假设高相关区域指示血管壁，进行血管壁的自动识别。当帧的差为33 ms时计算组织速度。组织速度成像被定义为高相关区域中的组织速度。经食管超声心动图（TEE）显示降主动脉短轴切面，中心频率4-7 MHz。同时记录心电图和血压。利用相邻帧中感兴趣区域的平方模板匹配方法计算二维组织速度矢量。比较IVUS结果和定向冠状动脉粥样硬化切除术切除的标本，比较TEE结果和血管切除的标本。血压变化引起的被动运动与组织成分和炎症细胞（如巨噬细胞）的表达相关。最后，在本研究中，应用超声波技术的生物力学的精确测量。

项目成果

Saijo Y, Hozumi N, Kobayashi K et al.: "Fast Fourier transform acoustic microscopy for biological tissues"Ultrasound Med Biol. 29・5s. S20-S20 (2003)

Saijo Y、Hozumi N、Kobayashi K 等：“生物组织的快速傅立叶变换声学显微镜”Ultrasound Med Biol.29・5s（2003 年）。

Tissue velocity imaging of coronary artery by rotating-type intravascular ultrasound.

• DOI: 10.1016/j.ultras.2003.11.022
• 发表时间: 2004-04
• 期刊: Ultrasonics
• 影响因子: 4.2
• 作者: Y. Saijo;A. Tanaka;N. Owada;Y. Akino;S. Nitta

Saijo Y, Tanaka A, Owada N et al.: "Intravascular tissue velocity imaging of coronary artery"Ultrasound Med Biol. 29・5s. S173-S173 (2003)

Saijo Y、Tanaka A、Owada N 等：“冠状动脉血管内组织速度成像”Ultrasound Med Biol. 29・5s (2003)。

Takahashi G, Tabayashi K et al.: "MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits"J Thorac Cardiovasc Surg. 126. 1461-1466 (2003)

Takahashi G、Tabayashi K 等人：“MCI-186 可防止兔子短暂性缺血后脊髓损伤并影响一氧化氮合酶和铜/锌超氧化物歧化酶的酶水平”J Thorac Cardiovasc Surg。

Oda K, Tabayashi K et al.: "Use of cuffed anastomosis in total aortic arch replacement"Ann Thorac Surg. 76. 952-953 (2003)

Oda K、Tabayashi K 等人：“在全主动脉弓置换术中使用套囊吻合术”Ann Thorac Surg。