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Renodeling treatment for cerebral aneurysms

脑动脉瘤再结治疗

基本信息

批准号：
15591517
负责人：
MIYACHI Shigeru
金额：
$ 2.24万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591517/
关键词：
experimental aneurysm remodeling cerebral aneurysm chitosan hyperthermia stent covered stent

项目摘要

1)The feasibility of photocrosslinkable chitosan as an embolization material for aneurysms was evaluated. Three experimental aneurysms were created in three Japanese white rabbits. All of the aneurysms were packed with chitosan hydrogel. Histopathologic data were analyzed on two, seven, and 30 days after embolization. Unorganized clots and minimal inflammation around the applied chitosan hydrogel were observed two days after implantation. After seven days, the chitosan was reduced and inflammatory response appeared. At 30 days, most of the aneurysm lumen was replaced with inflammatory cells, and the remaining chitosan was not observed. Severe complications such as anaphylaxis did not occur after the embolization with the chitosan. These results suggest that photocrosslinkable chitosan might be a candidate for an embolization material for endovascular treatment of cerebral aneurysms.2)Glass model aneurysms packed with coils were subjected to high-frequency altemating magnetic fields(AMF … More ) to investigate the correlation between weight of platinum and temperature elevation and the correlation between flow rates of water through the model and temperature elevation. Next, activated coagulation time(ACT) of blood obtained from dogs was studies at various temperatures. Finally, side-wall aneurysms created in the canine carotid artery using a venous patch were packed with platinum coils. Change in temperature and angiographic change were investigated after AMF. In the glass model, the weight of platinum was correlated with elevation of temperature, and a negative logarithmic correlation was evident between flow rate and elevation of temperature. Elevation of blood sample temperature tended to shorten ACT. In Canine carotid aneurysms, elevation of intra-aneurysmal temperature was confirmed and sufficient elevation of temperature was found to promote angiographically evident thrombogenesis of the remnant space after AMF application. Local hyperthermia may be useful in completing luminal obliteration of aneurysms after coil embolization. It may particularly usuful for ruptured aneurysms to prevent the early rerupture.3)Polturethan-coated stent was pplaced in three canine carotid artery resulted in complete thrombosis. Autologus endothelium was implanted on the polyurethan film to reduce the thrombogenisity. Cell culture was succeeded and attached endothelium layer on the film was found not to come off even after loading with various machnical stress like as steretch, rotation and the flow. Less

1)探讨光交联壳聚糖作为动脉瘤栓塞材料的可行性。在三只日本白色家兔中建立了三个实验性动脉瘤。所有动脉瘤均用壳聚糖水凝胶填塞。在栓塞后2、7和30天分析组织学数据。植入后两天，观察到应用的壳聚糖水凝胶周围的无组织凝块和轻微炎症。7天后，壳聚糖减少，出现炎症反应。30天时，大部分动脉瘤腔被炎性细胞取代，未观察到剩余的壳聚糖。壳聚糖栓塞后未发生过敏反应等严重并发症。这些结果表明，光交联壳聚糖可能是脑血管内治疗的栓塞材料的候选者。2）用弹簧圈填充的玻璃模型动脉瘤经受高频交变磁场（AMF ...更多信息）以研究铂的重量与温度升高之间的相关性以及通过模型的水的流速与温度升高之间的相关性。接着，在各种温度下研究从狗获得的血液的活化凝固时间（ACT）。最后，使用静脉补片在犬颈动脉中创建侧壁动脉瘤，并使用铂弹簧圈进行填充。观察AMF后体温变化和血管造影变化。在玻璃模型中，铂的重量与温度的升高相关，并且流量与温度的升高之间的负对数相关性是明显的。血样温度升高有缩短ACT的趋势。在犬颈动脉瘤中，证实了动脉瘤内温度升高，并且发现温度升高足以促进AMF应用后残余空间的血管造影明显血栓形成。局部热疗可能有助于弹簧圈栓塞后动脉瘤的腔内闭塞。对破裂的动脉瘤尤其适用于预防早期再破裂。3）在3只犬颈动脉内置入聚乙烯涂层支架，造成完全性血栓形成。在聚氨酯膜上植入自体内皮以减少血栓形成。细胞培养成功，膜上附着的内皮层在承受各种机械应力如旋转、旋转、流动等载荷后均未脱落。少