The study for solution of rupture and glowing of cerebral aneurysms using the novel flow simulation methods with MRI

MRI新型血流模拟方法解决脑动脉瘤破裂和发光的研究

• 批准号: 21591836
• 负责人: MIYACHI Shigeru
• 金额: $ 2.91万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591836/
• 关键词: 未破裂脳動脈瘤; 破裂リスク; コンピューターシミュレーション; 三次元画像; MRI; 血流解析; wall shear stress; MRi; 脳動脈瘤; computer fluid dynamics; MR fluid dynamics; 破裂; 増大; 血管モデル; 剪断力

BACKGROUND : Hemodynamics in intracranial aneurysms is thought to play an important role in their growth and rupture. Usual computed fluid dynamics(CFD) based on three-dimensional(3D) computed tomographic(CT) angiography requires a time-consuming process for analysis. Magnetic resonance fluid dynamics(MRFD) based on MR images is a new tool for analyzing flow dynamics and a promising method for obtaining such information more easily. We compared the data from MRFD and CFD and studied the clinical feasibility of MRFD.METHODS : A total of15aneurysms, including two ruptured ones, in15patients were investigated with MR imaging and 3D-CT angiography. The flow data of MRFD and CFD, 3D stream lines, flow velocity profile and wall shear stress(WSS) were extracted from the image reconstruction and were compared each other.RESULTS : Both flow dynamics images showed quite similar 3D flow pattern and WSS map. However, the calculated value of maximum WSS was quite different and there was no significant correlation. Further, in one ruptured case, CFD showed less visualization to evaluate the intra-aneurysmal flow.

背景：颅内动脉瘤的血流动力学被认为在其生长和破裂中起重要作用。基于三维（3D）计算机断层摄影（CT）血管造影术的血管计算机流体动力学（CFD）需要耗时的分析过程。基于磁共振图像的磁共振流体动力学（MRFD）是分析流体动力学的一种新工具，也是更容易获得此类信息的一种有前途的方法。方法：对15例患者共15个动脉瘤（包括2个破裂动脉瘤）进行MR成像和3D-CT血管造影检查。结果：MRFD和CFD的三维流场、三维流线、流速分布和壁面切应力（WSS）图基本一致，MRFD和CFD的三维流场、流速分布和壁面切应力图基本一致。然而，最大WSS的计算值相差很大，没有显著相关性。此外，在一个破裂的情况下，CFD显示较少的可视化，以评估颅内血流。

项目成果

治療困難な内頚動脈瘤に対する血管内治療の適用と問題点

难治性颈内动脉瘤腔内治疗的应用及问题

• 发表时间: 2009
• 作者: 宮地茂;泉孝嗣;松原功明;内藤丈裕;原口健一;市川剛;若林俊彦
• 通讯作者: 若林俊彦

The Importance of Position of the Neck Orifice. Assessment Using Computational Flow Simulation CS09

颈部孔口位置的重要性。

• 发表时间: 2009
• 作者: Miyachi S;Ohshima T;Hattori K;Takahashi I;Ishii K;Yoshida J The Risk of Aneurysmal Rupture
• 通讯作者: Yoshida J The Risk of Aneurysmal Rupture

Evaluation of the characteristics of various types of coils for the embolization of intracranial aneurysms with an optical pressure sensor system

光学压力传感器系统评价颅内动脉瘤栓塞用各类弹簧圈的特性

• DOI: 10.1007/s00234-010-0722-5
• 发表时间: 2011
• 期刊: Neuroradiolog
• 作者: Noriaki Matsubara;Shigeru Miachi;Yoshitaka Nagano;Tomotaka Ohshima;Osamu Hososhima;Takashi Izumi;Arihito Tsurumi;Toshihiko Wakabayashi;Akihito Sano;Hideo Fujimoto
• 通讯作者: Hideo Fujimoto

脳血管内治療における工学技術の応用

工程技术在脑血管治疗中的应用

• 发表时间: 2011
• 作者: Matsubara N;Miyachi S;Nagano Y;Ohshima T;Hososhima O;Izumi T;Tsurumi A;Wakabayashi T;Sakaguchi M;Sano A.;宮地茂;Miyachi S;宮地茂;宮地茂
• 通讯作者: 宮地茂

Fenestration of a Supraclinoid Internal Carotid Artery Associated With Dual Aneurysms: Case Report

• DOI: 10.1227/neu.0b013e318223b613
• 发表时间: 2011-10-01
• 期刊: NEUROSURGERY
• 影响因子: 4.8
• 作者: Ichikawa, Tsuyoshi;Miyachi, Shigeru;Koketsu, Naoki
• 通讯作者: Koketsu, Naoki