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Functional analysis of the neuronal network in patients with functional disorder of basal ganglia using non-invasive neurotransmitter imaging

使用无创神经递质成像对基底节功能障碍患者的神经网络进行功能分析

基本信息

批准号：
15591538
负责人：
SASAJIMA Hiroyasu
金额：
$ 2.24万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

The basal ganglia are undoubtedly among the most complex and least understood structures in the mammalian forebrain. In this study, we evaluated phosphoinositide turnover in the cerebrum and dopamine metabolism in the basal ganglia using ^<11>C-diacylglycerol-positron emission computed tomography(PET) and ^<18>F-fluorodopa-PET in patients with functional disorder of basal ganglia before and after treatment.^<11>C-diacylglycerol-PET of Parkinson's disease showed acceleration of the phosphoinositide turnover of the bilateral striatum and functional supression of the ipsilateral thalamus. These results indicate the superiority of the indirect pathway through subthalamic nucleus in patients with Parkinson's disease.^<11>C-diacylglycerol-PET studies in patients with cerebral infarction revealed hyperaccumlation in the prefrontal area in the subacute stage of cerebral infarction. The hyperaccumlation of ^<11>C-diacylglycerol in the prefrontal area in the subacute stage may indicate network plasticity in the cerebrum.Serial ^<18>F-fluorodopa-PET studies revealed hyperfunction of the presynaptic dopaminergic cells of the bilateral striatum in bobble-head doll syndrome. The suppression of output systems caused by hyperfunction of the presynaptic dopaminergic cells may play an important role of the occurrence of bobble-head doll movement.In the diffuse infiltrating tumor of the basal ganglia, ^<18>F-fluorodopa-PET study revealed that the presynaptic dopaminergic cells of the bilateral striatum were consistent within the tumor. In the expansive tumor such as metastatic tumors, ^<18>F-fluorodopa-PET showed accumulation of ^<18>F-fluorodopa in the striatum around the tumor. These results indicate that ^<18>F-fluorodopa-PET studies contribute to a qualitative diagnosis of the tumor in the basal ganglia.These PET data will be practical use for in vivo analysis of human basal ganglia and direct prediction of the network plasticity in the cerebrum.

基底神经节无疑是哺乳动物前脑中最复杂和最不了解的结构之一。在这项研究中，我们使用正<11>电子发射计算机断层扫描（PET）和<18>氟-氟多巴-PET评估了治疗前后基底神经节功能障碍患者大脑磷酸肌醇转换和基底神经节多巴胺代谢。<11>帕金森病患者的C-二酰甘油PET显示双侧纹状体的磷酸肌醇周转加快，同侧丘脑功能抑制。这些结果表明丘脑底核间接通路治疗帕金森病的优越性。<11>脑梗死患者的C-二酰甘油-PET研究显示，在脑梗死的亚急性期，前额区出现高血压。亚<11>急性期前额区的^C-二酰基甘油的高分泌可能表明大脑网络的可塑性。系列^<18>F-氟多巴-PET研究显示，摇头娃娃综合征双侧纹状体突触前多巴胺能细胞功能亢进。在基底节弥漫性浸润性肿瘤中，~（12）<18>F-fluorodopa-PET研究显示双侧纹状体的突触前多巴胺能细胞在肿瘤内分布一致，提示脑内多巴胺能细胞的异常活动可能是导致摇头娃娃运动的重要原因。在扩张性肿瘤如转移性肿瘤中，13 <18>F-氟多巴-PET显示13 <18>F-氟多巴在肿瘤周围的纹状体中积聚。这些结果表明，~（13 <18>F）-fluorodopa-PET显像有助于基底节区肿瘤的定性诊断，为在体分析人基底节区和直接预测大脑网络可塑性提供了实用的数据。