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Analysis of the synaptic plasticity in the human brain cortex-basal ganglia closed circuit disorder using the molecular image

利用分子图像分析人脑皮质-基底节闭路障碍的突触可塑性

基本信息

批准号：
21591854
负责人：
SASAJIMA Hiroyasu
金额：
$ 3万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

We analyzed a functional change of the neural network in the human basal ganglia disorder using PET from the viewpoint of signal transduction system noninvasively. In<11>^C-diacylglycerol-PET of stroke patients, because uptake of<11>^C-diacylglycerol was increased to prefrontal area for a sub-acute phase and attenuated after symptom improvement, it was estimated that this phenomenon reflected a plastic mechanism. In<11>^C-diacylglycerol-PET of patients with Parkinson's disease, the response was repeatable appeared after the simple exercise test and phosphoinositide turnover in striatum was enhanced. The activity of the ipsilateral thalamus was inhibited, and the superiority of the indirect tract which went through a subthalamic nucleus was shown. In a new case of bobble-head doll syndrome known as craniocervical dyskinesis, we reviewed that the presynaptic function of dopamine cells in the striatum was enhanced by<18>^F-fluorodopa-PET. In basal ganglia tumors, dopamine cells made it dispersion in a tumor for diffuse tumor indicating the growth in the cerebral parenchyma, and the expansive accumulation of dopamine cells was confirmed for tumor indicating the extraparenchymal growth, and it became clear to contribute to the qualitative diagnosis of tumor, and it was confirmed that the presynaptic function of dopamine cells in the basal ganglia recovered after treatment. The biochemical information obtained by the PET studies contributes to mechanism elucidation of the neural plasticity in the basal ganglia.

我们用PET从信号转导系统的角度无创性地分析了人类基底神经节疾病中神经网络的功能变化。在<11>中风患者的^C-二酰基甘油-PET中，由于<11>^C-二酰基甘油的摄取在亚急性期增加到前额区域，并且在症状改善后减弱，因此估计该现象反映了可塑性机制。帕金森<11>病患者运动试验后的^C-二酰甘油-PET反应可重复出现，纹状体磷酸肌醇转换增强。同侧丘脑的活动受到抑制，并显示出通过丘脑底核的间接束的优势。在一例新的被称为颅颈运动障碍的摇头娃娃综合征病例中，我们回顾了纹状体多巴胺细胞的突触前功能被<18>13 F-氟多巴-PET增强。在基底神经节肿瘤中，对于表示脑实质内生长的弥漫性肿瘤，多巴胺细胞使其分散在肿瘤中，对于表示脑实质外生长的肿瘤，确认了多巴胺细胞的扩张性积聚，并且变得清楚有助于肿瘤的定性诊断，并且确认了基底神经节中多巴胺细胞的突触前功能在治疗后恢复。PET研究所获得的生化信息有助于阐明基底节神经可塑性的机制。