Elucidation of genetic-environmental interaction and prevention for gestosis
阐明遗传-环境相互作用和妊娠中毒症的预防
基本信息
- 批准号:15591723
- 负责人:
- 金额:$ 2.05万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1.To clarify the interactions among the candidate gene polymorphisms for the occurrence of pregnancy-induced hypertension (PIH), we carried out genotyping of the genes associated with blood coagulation, such as C677T of methylenetetrahydrofolate reductase gene, Leiden mutation of factor V gene, G20210A of prothrombin gene and 4G/5G of plasminogen actibator inhibitor gene (PAI-I). The results showed that frequencies of 4G/4G of PAI-I ware 41% in PIH cases and 39% in controls, and no significant difference was found between them. However, frequencies of homozygote of T235 of angiotensinogen gene (AGT), which is reported risk factor for PIH, were significantly higher in PIH cases (78%, n=56) than controls (56%, n=121) in the subgroup possessing 4G/4G of PAI-I (p=0.008), while no significant difference was found between PIH cases (71%, n=82) than controls (60%, n=202) in the subgroup possessing 5G/5G or 4G/5G of PAI-I. Frequencies of heterozygote of Glu298Asp or homozygote of Asp298 of the endotherial nitric oxide synthase gene (NOS3), which is also reported risk factor for PIH, were 18% in PIH cases (n=51) and 10% in controls (n=114) in the subgroup possessing 4G/4G, and 30% in PIH cases (n=74) and 15% in controls (n=190) in the subgroup possessing 5G/5G or 4G/5G of PAI-I. Significant difference was found only in the latter subgroup (p<0.008).2.In order to develop a stress checklist for pregnant women to use examinations and interventions, we performed personal interview and focus group interview in obstetrical department. Emesis, body change by pregnancy, health control methods during pregnancy, economical burden, relationship to parents, child care in the near future, etc. were found to be the stress factors of the pregnant women.
1.为明确妊高征发病的候选基因多态性之间的相互作用,我们对凝血相关基因进行了分型,如亚甲基四氢叶酸还原酶基因C677 T、凝血因子V基因Leiden突变、凝血酶原基因G20210 A和纤溶酶原激活物抑制剂基因4G/5G。结果表明,妊高征组PAI-Ⅰ 4G/4G频率为41%,对照组为39%,两组间无显著性差异。而血管紧张素原基因(AGT)T235纯合子在妊高征患者中的频率明显增高(78%,n=56)PAI-I 4G/4G亚组为56%,n=121妊高征组PAI-Ⅰ 5G/5G和4G/5G阳性率分别为71%(82例)和60%(202例),两组间差异无统计学意义。内皮型一氧化氮合酶基因(NOS 3)Glu 298 Asp杂合子或Asp 298纯合子的频率在4G/4G亚组中分别为18%(n=51)和10%(n=114),在PAI-I为5G/5G或4G/5G的亚组中,PIH病例组(n=74)为30%,对照组(n=190)为15%。2.采用个人访谈和焦点小组访谈的方法,在产科进行孕妇压力量表的编制,以便于孕妇进行检查和干预。孕妇的压力因素有呕吐、孕期身体变化、孕期保健方法、经济负担、与父母的关系、近期照顾子女等。
项目成果
期刊论文数量(48)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Insertion/deletion polymorphism of angiotensin-converting enzyme gene and preeclampsia in Japanese.
日本人血管紧张素转换酶基因插入/缺失多态性与先兆子痫。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:Kobashi G;Hata A;Ohta K;et al.
- 通讯作者:et al.
Kobashi G, Hata A, et al.: "A1166C variant of angiotensin II type 1 receptor gene independently associated with severe hypertension in pregnancy from T235 variant of angiotensinogen gene"J Hum Genet. (in press).
Kobashi G、Hata A 等人:“血管紧张素 II 1 型受体基因的 A1166C 变体与血管紧张素原基因的 T235 变体独立地与妊娠期严重高血压相关”J Hum Genet。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
The Egogram is a Potent, Independent Risk Factor for Hypertension in Pregnancy in Japanese Women.
心电图是日本女性妊娠期高血压的一个有效的独立危险因素。
- DOI:
- 发表时间:2005
- 期刊:
- 影响因子:0
- 作者:Kobashi G;Ohta K;et al.
- 通讯作者:et al.
Kobashi G, Hata A, et al.: "Insertion/deletion polymorphism of angiotensin-converting enzyme gene and preeclampsia in Japanese"Seminor Thromb Hemostat. (in press).
Kobashi G,Hata A,等:“日本血管紧张素转换酶基因的插入/缺失多态性与先兆子痫”Seminor Thromb Hemostat。
- DOI:
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- 影响因子:0
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KOBASHI Gen其他文献
KOBASHI Gen的其他文献
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{{ truncateString('KOBASHI Gen', 18)}}的其他基金
Study for elucidation of gene-environment interaction in the manifestation of pregnancy-induced hypertension
阐明妊娠高血压综合征基因-环境相互作用的研究
- 批准号:
22591842 - 财政年份:2010
- 资助金额:
$ 2.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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