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A study regarding the mechanism of hearing loss in development of endolymphatic hydrops in Meniere's disease

梅尼埃病内淋巴积水导致听力损失的机制研究

基本信息

批准号：
15591829
负责人：
NAGANUMA Hideaki
金额：
$ 2.18万
依托单位：
KITASATO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

It was thought that the disorder of accommodation in water transport in membranous labyrinth let the homeostatic function of ion transport in endo- and peri-lymph failure. This fail caused to endolymphatic hydrops that was a morphological disorder in inner ear. Though the mechanism of its occurrence still remains unclear, various lines of experimental and clinical evidence indicate a possible roll of AVP in development of endolymphatic hydrops in MD. In our previous study entitled "A study regarding the mechanism in development of endolymphatic hydrops in MD" (Grant-in-Aid for Scientific Research (C)(2), the hearing loss was occurred in the animal model by administering AVP. This hearing loss was sometime repaired. The purpose in present study was to elucidate the mechanism of this hearing loss.The dose of AVP in the experiments was 0.02units/g. It was investigated whether the endolymphatic hydrops was formed by administration of same dose of AVP. As the results, the endolymphatic hydrops was not formed in light microscope level by administration of same dose of AVP. These results mean that the hearing loss was occurred without the morphological disorder of endolymphatic hydrops. As the next step, it was necessary to investigate some physiological disorders in administration of AVP.Therefore, it was investigated whether the cochlear endolymphatic D-C Potential (EP) had an influence on the administrating AVP in our animal model. As the results, EP was decreased statistically in 2-10 minutes after administrating of AVP. It was thought that the function of stria vascularis was changed before the formation of endolymphatic hydrops and hearing was impaired.In next study, it was planed that the function and morphological change of stria vascularis were investigated by administrating AVP.

认为膜迷路中水分转运调节的紊乱使离子转运在淋巴内和淋巴周围衰竭中具有稳态功能。这种失败导致内耳淋巴水肿，这是一种形态学紊乱。虽然其发生的机制尚不清楚，但各种各样的实验和临床证据表明，AVP可能在MD内淋巴水肿的发生中起作用。在我们之前的一项名为“关于MD内淋巴水肿发生机制的研究”(科学研究资助基金（C)(2)）的研究中，给药AVP在动物模型中发生了听力损失。这种听力损失有时会得到修复。本研究的目的是阐明这种听力损失的机制。实验中AVP的剂量为0.02单位/g。观察相同剂量AVP是否形成内淋巴积液。结果表明，相同剂量的AVP在光镜下未形成内淋巴积液。这些结果表明，听力损失的发生没有内淋巴水肿的形态学障碍。下一步，有必要研究AVP给药过程中的一些生理障碍。因此，我们在动物模型中探讨耳蜗内淋巴D-C电位（EP）是否对AVP给药有影响。结果显示，AVP给药后2 ~ 10分钟，EP明显降低。在形成内淋巴积液和听力受损之前，认为血管纹的功能发生了改变。在下一步的研究中，我们计划通过给药AVP观察血管纹的功能和形态变化。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Three-dimensional analysis of morphological aspects of the human utricular macula.

人类椭圆囊黄斑形态方面的三维分析。

DOI：
10.1177/000348940311200506
发表时间：
2003
期刊：
The Annals of otology, rhinology, and laryngology
影响因子：
0
作者：
Naganuma,Hideaki;Tokumasu,Koji;Okamoto,Makito;Hashimoto,Shinichiro;Yamashina,Shohei
通讯作者：
Yamashina,Shohei

Naganuma H., Tokumasu K., Okamoto M, Yamashina S: "THREE-DIMENSIONAL ANALYSIS OF MORPHOLOGICAL ASPECTS OF THE HUMAN UTRICULAR MACULA"Ann Otol Rhinol Laryngol. 112(5). 419-424 (2003)

Naganuma H.、Tokumasu K.、Okamoto M、Yamashina S：“人类椭圆囊黄斑形态方面的三维分析”Ann Otol Rhinol Laryngol。