Establishment of non-destructive quantitative measurements of the mineral concentrations for the fine structure in hard tissue by using micro CT

利用显微CT建立硬组织精细结构矿物质浓度无损定量测量方法

• 批准号: 15591955
• 负责人: KAWASAKI Kenzo
• 金额: $ 2.18万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591955/
• 关键词: micro computed tomography,; bone mineral density; BMD; X ray spectrum; scattered radiation; beam hardening effects; マイクロCT

This project was planed to establish of non-destructive quantitative measurements of mineral concentrations for fine structure in hard tissue by using micro-CT. To complete of this aim, we designed four main studies as follows ; 1)basic studies of the factors influencing density of micro-CT, 2)proposal and manufacture of the measuring instrument for quantitative measurements of mineral concentrations by using micro-CT, 3)the application of this study for the human dentine, 4)development of artifact reduction method for micro-CT image in mineralized hard tissue.1)Basic studies of the factors influencing density of micro-CT. The density of the micro-CT images were affected by sample size and magnification at the measurements. It were also observed that air revel fluctuation by scattered radiation and a principle of reconstruction of the images, and the uneven nesses of the density in the image caused by the spectrum of X rays.2)Proposal and manufacture of the measuring instrument for qua … More ntitative measurements of mineral concentrations by using micro-CT. The measuring instrument was designed for columnar shape made by aluminum cup which inside equipped with four different concentrations of the mixture of hydroxyapatite and carbon. And the unknown samples of the mineral density were determined by drawing the calibration linear regression line from the data of known the standard mineral density.3)Application of this study for the human dentine. Using the instruments, the mineral contents of human dentine samples age 26 to 78 were measured. As a result, increasing of the mineral contents in both normal and translucent dentine was observed.4)Developmental study of the artifact reduction method for micro-CT image in mineralized hard tissue. To reduce the artifact of micro CT images, we developed a method that the samples were embedded in compensating materials.Over all results indicates the aim of this project were completed successfully. However, the confirmation studies of the accuracy by this method were still remaining, such as repeats of measurements of the density, comparison with chemical analysis and so on. Less

本课题旨在利用显微CT技术建立硬组织中微细结构矿物质含量的无损定量测量方法。为了完成这一目标，我们设计了以下四个主要研究：1）micro-CT密度影响因素的基础研究; 2）micro-CT定量测量矿物质浓度测量仪的研制; 3）本研究在人牙本质中的应用; 4）矿化硬组织显微CT图像伪影消除方法的建立。1）影响显微CT密度因素的基础研究。显微CT图像的密度受样本大小和测量时放大倍数的影响。本文还观察到了散射辐射引起的空气波动和图像重建的原理，以及X射线光谱引起的图像密度不均匀性。2）质量检测仪的研制 ...更多信息 使用微型CT进行矿物浓度的初步测量。该测量仪是针对圆柱形的铝杯设计的，铝杯内装有四种不同浓度的羟基磷灰石和碳的混合物。根据已知标准矿物密度数据绘制校准线性回归线，确定未知样品的矿物密度。3）本研究应用于人牙本质。使用该仪器，测量了26至78岁的人牙本质样品的矿物质含量。4）矿化硬组织显微CT图像伪影消除方法的研究。为了减少显微CT图像的伪影，我们提出了一种将样品埋入补偿材料中的方法，实验结果表明，本课题的研究目标是成功的。然而，通过这种方法的准确性的确认研究仍然存在，例如重复测量密度，与化学分析进行比较等等。Less

项目成果

X-ray Micro-CT Study of Mineral Concentrations in Human Dentine.

人类牙本质矿物质浓度的 X 射线显微 CT 研究。

• 发表时间: 2004
• 期刊: Journal of Dental Research 83・SIA
• 作者: S.SHIMODA;K.KOBAYASHI;K.KAWASAKI
• 通讯作者: K.KAWASAKI

マイクロCT画像における石灰化組織のアーチファクト低減法

显微CT图像中钙化组织的伪影减少方法

• 期刊: 日本口腔インプラント学会誌 (投稿中)
• 作者: 下田信治;森田康彦;樋口慎一;小林 馨;川崎堅三
• 通讯作者: 川崎堅三

Artifact Reduction Method for Micro-CT Image in Mineralized Hard Tissue.

矿化硬组织中显微 CT 图像的伪影减少方法。

• 期刊: Journal of Japanese Society of Oral Implantology (in submission)
• 作者: SHIMODA Shinji;MORITA Yasuhiuko;HIGUCHI Shinichi;KOBAYASHI Kaoru;KAWASAKI Kenzo
• 通讯作者: KAWASAKI Kenzo

S.SHIMODA, K.KOBAYASHI, K.KAWASAKI: "X-ray Micro-CT Study of Mineral Concentrations in Human Dentine."Journal of Dental Research. 83・SIA. 2164 (2004)

S.SHIMODA、K.KOBAYASHI、K.KAWASAKI：“人体牙本质矿物质浓度的 X 射线显微 CT 研究”。牙科研究杂志 83・SIA 2164 (2004)。