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Development of antibacterial composite resins containing photocatalysis titanium dioxide

含光催化二氧化钛抗菌复合树脂的研制

基本信息

批准号：
15592075
负责人：
TAIRA Miyasaka
金额：
$ 2.18万
依托单位：
The Nippon Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592075/
关键词：
photocatalyst titanium dioxide antibacterial effect composite resin mechanical property

项目摘要

Three sort of photocatalyst titanium dioxide in different particle sizes of 6, 30, 180nm were added to the experimental composite resins by replacing the part of silica filler with 1, 3, 5, 10, 20, 30 mass%. The compressive strength, diametral tensile strength and bending strength of cured experimental composites was observed. The antibacterial effect was investigated by means of e. coli, and fracture surfaces were observed by SEM and EPMA, then the following conclusions were obatained.1) The compressive strength showed the tendency of decreasing when the contents of titanium dioxide increased, and in more than 20% the compressive strength decreased as the particle size of titanium dioxide increased.2) The diametral tensile strength showed the similar tendency of decreasing with the increase of titanium dioxide content, and when the particle size became more than 30nm, the diametral tensile strength decreased with the addition of more than 10%.3) The bending strength decreased rapidly with the addition of more than 20%, and the smaller the particle sizes became, the greater the bending strength became.4) The antibacterial effects were observed for all experimental composite containing titanium dioxide, especially the composites containing titanium oxide of particle size of more than 30nm showed significant antibacterial effect.5) From the observation of fracture surfaces by SEM and EPMA, the mixed conditions of titanium dioxide were homogeneous.From these observations, the light curing composite resins containing photocatalyst titanium dioxide have great potential as an antibacterial dental filling material.

以1、3、5、10、20、30质量%的TiO 2颗粒代替部分SiO2填料，将粒径分别为6、30、180 nm的三种TiO 2光催化剂添加到实验复合树脂中。观察了固化后复合材料的压缩强度、径向拉伸强度和弯曲强度。采用大肠杆菌法研究了抗菌效果。结果表明：随着二氧化钛含量的增加，复合材料的抗压强度呈下降趋势，当二氧化钛含量超过20%时，复合材料的抗压强度随二氧化钛粒径的增加而下降;随着二氧化钛含量的增加，复合材料的径向抗拉强度也呈下降趋势，当粒径大于30 nm时，复合材料的径向拉伸强度随添加量的增加而降低; 3）当添加量大于20%时，复合材料的抗弯强度急剧下降，且粒径越小，抗弯强度越大; 4）所有实验材料均具有抗菌效果，特别是含有大于30 nm的二氧化钛的复合材料显示出显著的抗菌效果。5）通过SEM和EPMA观察断裂表面，二氧化钛的混合条件是均匀的。从这些观察，含有光催化剂二氧化钛的光固化复合树脂具有作为抗菌牙科填充材料的巨大潜力。