Development of an Anti-Viral coating for Pandemic Mitigation of COVID-19 using titanium dioxide nanoparticles

使用二氧化钛纳米粒子开发抗病毒涂层以缓解 COVID-19 疫情

• 批准号: 551074-2020
• 负责人: Didar, Tohid
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=701688
• 关键词: Development; Anti; Viral; coating; Pandemic

SARS-CoV-2 remains active on various surfaces for up to 72 hours creating a network of contaminated surfaces, enabling rapid spread of the virus. In this project we propose to address this issue by preventing the transition of the virus through surface contamination. we propose to design a new type of coating containing TiO2 nanoparticles which, under visible light, can annihilate the SARS-CoV-2 viruses that are attached to high risk surfaces via microdroplets or touch. This could significantly prevent cross-contamination and rapid spread of the virus. We will incorporate the photoactive TiO2 nanoparticles in the form of sprays and paint which are the two most-commonly used techniques for coating surfaces. Consequently, the new type of coating can simply be applied to a variety of surfaces and already built-in parts such as knobs, handles, walls, ceilings, and biomedical instruments. TiO2 particles are photocatalytically active under UV irradiation and can photo-kill capsid proteins of SARS-CoV-2 viruses in a short time. Moreover, Titania is a low-cost material and possesses very low toxicity and high chemical stability. In order to induce photocatalytic properties in TiO2 nanoparticles under visible light, we will dope the particles with nitrogen using a single-step heat treatment technique. In collaboration with our industry partner (Nanophyll Inc.) we are determined to design a pilot production line and rapidly commercialize our final product in the form of an antiviral paint or spray. Our industrial collaborator's considerable experience in developing and manufacturing smart coatings for bacteria and fouling resistant as well as self-cleaning, will greatly help with rapid commercialization of the developed coatings using the potential of Nanophyll's strategic partners.

SARS-CoV-2在各种表面上保持活性长达72小时，形成受污染表面的网络，使病毒能够迅速传播。在这个项目中，我们建议通过防止病毒通过表面污染的转移来解决这个问题。我们建议设计一种含有TiO2纳米粒子的新型涂层，该涂层在可见光下可以通过微滴或触摸消灭附着在高风险表面上的SARS-CoV-2病毒。这可以显著防止病毒的交叉污染和快速传播。我们将以喷雾和油漆的形式加入光活性TiO2纳米粒子，这是两种最常用的表面涂层技术。