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Left Ventricular Motion Simulation based on Myocardial Cell Model

基于心肌细胞模型的左心室运动模拟

基本信息

批准号：
16500186
负责人：
AMONO Akira
金额：
$ 2.37万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500186/
关键词：
Biomedical Simulation Heart Model Myocardial Cell Model Finite Element Method Coupling Simulation Algorithm

项目摘要

In this research, we developed a left ventricle model which incorporates accurate cell model based on the recent advances in the cell physiology research area and other biomechanical aspects which includes cell orientation, material properties of the myocardial tissue and circulation model. First, we developed an authoring tool of the left ventricle model which can modify many parameters included in the model. Next, we developed a coupling simulation system which can use arbitrary circulation model and the left ventricle model. We also developed a description language which can describe a left ventricle model or myocardial cell model and also an experimental protocol. These tools offer formal representation of biological simulation models and by combining ontology information, many researchers from engineering area or information science area can safely handle these models. Finally, we used our model to simulate the left ventricle motion and evaluated the end systolic wall stress. There are hypothesis that the wall stress becomes homogeneous in the normal left ventricle. However, from our simulation results, we found that the wall stress in the apex area becomes large compared to the other area. This implies that the wall motion at apex is different from the other area, and this finding may related to the empirical knowledge of the heart surgeon that the preserving apex area in Batista operation is important for the prognosis.

在这项研究中，我们开发了一种左心室模型，该模型结合了基于细胞生理学研究领域和其他生物力学方面的最新进展（包括细胞定向、心肌组织的材料特性和循环模型）的精确细胞模型。首先，我们开发了左心室模型的创作工具，它可以修改模型中包含的许多参数。接下来，我们开发了一个可以使用任意循环模型和左心室模型的耦合模拟系统。我们还开发了一种可以描述左心室模型或心肌细胞模型的描述语言以及实验方案。这些工具提供了生物模拟模型的形式化表示，并且通过结合本体信息，来自工程领域或信息科学领域的许多研究人员可以安全地处理这些模型。最后，我们使用我们的模型来模拟左心室运动并评估收缩末期壁应力。有假设认为正常左心室的壁应力变得均匀。然而，从我们的模拟结果来看，我们发现与其他区域相比，顶点区域的壁应力变大。这意味着心尖处的室壁运动与其他区域不同，这一发现可能与心脏外科医生的经验知识有关，即巴蒂斯塔手术中保留心尖区域对预后很重要。