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Examination and execution of cancer research using virtual microscopy

使用虚拟显微镜检查和执行癌症研究

基本信息

批准号：
17590304
负责人：
OGA Atsunori
金额：
$ 2.24万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590304/
关键词：
pathology information technology virtual slide tissue microarray telemedicine breast cancer genome oral cancer Tissue microarray バーチャル顕微鏡組織アレイ CGH サーバー

项目摘要

The research using tissue microarray was announced in the symposium of the Japan Cytometry Society in July, 2006.Afterwards, various parameters were combined as effectively as possible, and it succeeded in the improvement of judgment of the prognosis of breast cancers except stage IV. The virtual slide system improved the efficiency of the data accumulation and comparison. The genomic analysis of cancer research accompanied with morphological approaches has been performed in our laboratory. For example, we reported on two different genetic pathways for carcinogenesis of oral squamous cell carcinoma, and accumulations of large-sized genomic aberration in non-neoplastic cells as English paper, respectively. The combined study (genomic analysis using DNA-chip and gene expression analysis by immunohistochemical staining) in rare type of salivary gland cancer has been performed. Moreover, it was proven to use virtual slide, to execute the diagnostic consultation for pathological specimens between remote places, and to be able to obtain effective information within 30 minutes. Clinical and pathology conference using virtual slide system between remote places via internet were performed. This virtual slide system was used for medical student education, too. We uploaded digital files of guide for pathological training including the histological images, and it was able to be downloaded, used and modified easily by medical students. It reported on application of virtual slide system to education, cancer research, or surgical pathology in the workshop session of Japanese Society of Pathology in March, 2007. In conclusion, virtual slide system is effective for cancer research, education, and surgical pathology.

在2006年7月的日本细胞术学会研讨会上公布了组织微阵列的研究成果。之后，将各项参数尽可能有效地结合起来，成功地提高了对除ⅳ期外乳腺癌预后的判断。虚拟切片系统提高了数据积累和比较的效率。癌症研究的基因组分析伴随着形态学方法已经在我们的实验室进行。例如，我们分别作为英文论文报道了口腔鳞状细胞癌的两种不同的致癌遗传途径，以及非肿瘤细胞中大量基因组畸变的积累。对罕见型唾液腺癌进行了dna芯片基因组分析和免疫组织化学染色基因表达分析的联合研究。此外，还证明了利用虚拟载玻片，在异地间对病理标本进行诊断会诊，30分钟内即可获得有效信息。通过网络进行异地间的临床和病理会议，采用虚拟幻灯片系统。这种虚拟幻灯片系统也被用于医学生的教育。我们上传了包括组织学图像在内的病理训练指南数字文件，供医学生下载、使用和修改。在2007年3月日本病理学会研讨会上报告了虚拟幻灯片系统在教育、癌症研究、外科病理等方面的应用。综上所述，虚拟载玻片系统在癌症研究、教育和外科病理方面是有效的。