Search for genes associated with genome copy number imbalance in human cancer

寻找与人类癌症基因组拷贝数不平衡相关的基因

基本信息

  • 批准号:
    14570147
  • 负责人:
  • 金额:
    $ 2.18万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2004
  • 项目状态:
    已结题

项目摘要

Many of human carcinomas show DNA aneuploidy with DNA index 1.3 or more. We think that this is one of basic feature of human carcinoma, however, little is known about the mechanism of acquisition of DNA aneuploidy. For detecting overall genome copy number aberration in detail and approaching to genes associated with the mechanism of acquisition of DNA aneuploidy, some carcinomas have been analyzed by comparative genomic hybridizations. The head investigator and other researchers (we) found and reported that a recurrent DNA copy number aberration (gain) at 18p in mucinous type colorectal carcinoma with DNA aneuploidy. Furthermore, we have reported that centrosome hyperamplification associated with DNA ploidy, 20q13, on which the Aurora-A gene is located, copy number increasing or tumor recurrence in bladder cancer. In addition to them, the head investigator took chances for publications about DNA aneuploidy in solid tumors and technical notes for DNA measurement with cytometer in Japanese. We have tried other experiments, for example, an experiment to induce DNA ploidy abnormality using cultured cell or to detect genome copy aberrations in precancerous lesions. We are preparing for publishing based on results from these experiments.
许多人类肿瘤显示DNA非整倍体,DNA指数为1.3或更高。我们认为这是人类肿瘤的基本特征之一,但对DNA非整倍体获得的机制还知之甚少。为了更详细地检测基因组拷贝数的异常,并探讨与DNA非整倍体获得机制相关的基因,人们对一些肿瘤进行了比较基因组杂交分析。本课题组组长和其他研究人员发现并报道了粘液型结直肠癌中18 p处的DNA拷贝数异常(增加),并伴有DNA非整倍体。此外,我们还报道了中心体过度扩增与膀胱癌中Aurora-A基因所在的20 q13 DNA倍体、拷贝数增加或肿瘤复发相关。除此之外,首席研究员还利用机会发表了关于实体瘤中DNA非整倍体的出版物和使用细胞仪进行DNA测量的技术说明(日语)。我们还尝试了其他实验,例如,使用培养细胞诱导DNA倍性异常或检测癌前病变中的基因组拷贝畸变的实验。我们正在准备根据这些实验的结果发表。

项目成果

期刊论文数量(44)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low- and high- grade tumors.
多色 FISH 和细胞计数分析可将尿路上皮癌分为两种亚型:低级别肿瘤和高级别肿瘤。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ikemoto K;et al.
  • 通讯作者:
    et al.
Ueno T, et al.: "Prediction of Nodal Metastasis by Comparative Genomic Hybridization in Biopsy Specimens from Patients with Superficial Esophageal SCC"Clinical Cancer Research. 9・14. 5137-5141 (2003)
Ueno T 等人:“浅表食管 SCC 患者活检标本中比较基因组杂交的淋巴结转移预测”临床癌症研究 9·14(2003 年)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH
  • DOI:
    10.1038/modpathol.3800107
  • 发表时间:
    2004-06-01
  • 期刊:
  • 影响因子:
    7.5
  • 作者:
    Hashimoto, K;Mori, N;Sasaki, K
  • 通讯作者:
    Sasaki, K
フローサイトメトリー自由自在(分担執筆 細胞周期)
可供您使用的流式细胞术(共同撰写的细胞周期)
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    小賀 厚徳(分担執筆)
  • 通讯作者:
    小賀 厚徳(分担執筆)
Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low-and high-grade tumors
多色 FISH 和细胞计数分析可将尿路上皮癌分为两种亚型:低级别肿瘤和高级别肿瘤
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OGA Atsunori其他文献

OGA Atsunori的其他文献

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{{ truncateString('OGA Atsunori', 18)}}的其他基金

Research which paid attention to the ABO type blood type about the protective mechanism over stomach cancer
关注ABO血型对胃癌保护机制的研究
  • 批准号:
    22659117
  • 财政年份:
    2010
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Examination and execution of cancer research using virtual microscopy
使用虚拟显微镜检查和执行癌症研究
  • 批准号:
    17590304
  • 财政年份:
    2005
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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高分辨率阵列比较基因组杂交对成釉细胞瘤进行基因组诊断及分子靶点药物开发
  • 批准号:
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Genomic Profiling of Submucosal-Invasive Gastric Cancer by Array-Based Comparative Genomic Hybridization
通过基于阵列的比较基因组杂交对粘膜下浸润性胃癌进行基因组分析
  • 批准号:
    23790409
  • 财政年份:
    2011
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    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Screening copy number variations by array comparative genomic hybridization in 30 patients with congenital hypopituitarism.
通过阵列比较基因组杂交筛选 30 例先天性垂体功能减退症患者的拷贝数变异。
  • 批准号:
    22790999
  • 财政年份:
    2010
  • 资助金额:
    $ 2.18万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Exhaustive genetic analysis for congenital hypomyelination disorders using Comparative Genomic Hybridization Array.
使用比较基因组杂交阵列对先天性髓鞘形成不足疾病进行详尽的遗传分析。
  • 批准号:
    22591120
  • 财政年份:
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Characterization of a grape variety'Koshu' through comparative genomic hybridization and transcriptomic analysis
通过比较基因组杂交和转录组分析表征葡萄品种“Koshu”
  • 批准号:
    21580050
  • 财政年份:
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Genomic profiling of gastric carcinoma in situ by array-based comparative genomic hybridization
通过基于阵列的比较基因组杂交对胃癌进行原位基因组分析
  • 批准号:
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  • 财政年份:
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Array Comparative Genomic Hybridization of Enchondroma and Grade 1 Chondrosarcoma
内生软骨瘤和 1 级软骨肉瘤的芯片比较基因组杂交
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  • 财政年份:
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开发基于阵列的比较基因组杂交(CGH)作为先天性疾病中隐性染色体畸变的诊断工具
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    17390099
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Analysis of glioblastoma stem cell derived from bone marrow stem cell using high-resolution array-based comparative genomic hybridization
使用基于高分辨率阵列的比较基因组杂交分析源自骨髓干细胞的胶质母细胞瘤干细胞
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使用 DNA 微阵列和比较基因组杂交研究智力障碍的基因组变化
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