Cost and benefit of the genetic diagnosis for diabetes mellitus as a screening test.

糖尿病基因诊断作为筛查测试的成本和效益。

• 批准号: 17590450
• 负责人: OHSAWA Isao
• 金额: $ 0.83万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590450/
• 关键词: diabetes mellitus; genetic diagnosis; simulation model; decision analysis

Several diabetes susceptibility genes have been identified recently and expected to be used as screening tests for diabetes and/or diabetic complications.1.A Markov decision analytic model (computerized simulation model) of diabetes mellitus was constructed to evaluate the health implications of examining gene profiles as one of the screening tests for diabetes. The model incorporated the likelihood of developing diabetes and/or diabetic complications, costs, survival year and quality of life. Because of scarce published literature about the health benefits of genetic diagnosis and the weakness of the model structure itself, the simulation process needs further amelioration to accomplish the purpose.2.Through MEDLINE and Japna Centra Revuo Medicina (Ichushi) searches, we retrieved and reviewed English-language and Japanese-language articles about the genetic predisposition to diabetes mellitus, the effectiveness of gene profile examination on health benefits, and the decision and economical analyses of the genetic diagnosis. A lot of articles have dealt with the genetic problems through biological and molecular techniques. But scarce evidence has been reported about the health benefits of the genetic tests for lifestyle related disease such as diabetes mellitus. Some kinds of genetic profile examinations have already been innovated in diabetes fields. Health benefits of genetic diagnosis of diabetes remains to be investigated from several viewpoints such as quality of life, bioethics, and health economics.

最近发现了一些糖尿病易感基因，有望用于糖尿病和/或糖尿病并发症的筛查。1.构建了糖尿病的马尔可夫决策分析模型(计算机化模拟模型)，以评估作为糖尿病筛查之一的基因谱检查对健康的影响。该模型包含了患糖尿病和/或糖尿病并发症的可能性、成本、生存年和生活质量。2.通过MEDLINE和JAPNA Centra Revuo Medicina(Ichushi)的检索，我们检索并综述了关于糖尿病的遗传易感性、基因图谱检查对健康益处的有效性以及基因诊断的决策和经济分析的英文和日文文章。很多文章都是通过生物和分子技术来解决遗传问题的。但关于糖尿病等与生活方式相关的疾病的基因测试对健康有益的证据很少。在糖尿病领域，一些类型的基因图谱检测已经被创新。糖尿病基因诊断的健康益处仍有待从生活质量、生命伦理学和健康经济学等多个角度进行调查。