Proteomic analysis of liver cells infected with hepatitis C virus
丙型肝炎病毒感染肝细胞的蛋白质组学分析
基本信息
- 批准号:17590647
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2006
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Chronic infection of hepatitis C virus (HCV) is closely related with hepatocarcinogenesis. Although considerable progress has been made during recent years, the mechanism of carcinogenesis is still in discussion. We have employed proteomic techniques in an HCV replicon cell, to elucidate the mechanism of hepatocarcinogenesis in HCV infected patients. By comparing the protein expression profiles of HCV subgenomic replicon cell line and its cured cell, we obtained several proteins that were positively expressed in replicon cells. There were several proteins that could be associated with cell proliferation and apoptosis control including UCH-L1, TCP-1, RALDH1, and Elongation factor 2. Such an analysis of protein expression profile in HCV replication cells will extend our understanding of the mechanism of HCV hepatocarcinogenesis.
丙型肝炎病毒(HCV)慢性感染与肝癌的发生密切相关。虽然近年来已经取得了相当大的进展,但致癌机制仍在讨论中。我们采用蛋白质组学技术在HCV复制子细胞中,阐明HCV感染患者肝癌发生的机制。通过比较HCV亚基因组复制子细胞系及其治愈细胞的蛋白质表达谱,获得了几个在复制子细胞中阳性表达的蛋白质。有几种蛋白可能与细胞增殖和凋亡控制相关,包括UCH-L1,TCP-1,RALDH 1和延伸因子2。对HCV复制细胞中蛋白质表达谱的分析将有助于加深对HCV肝癌发生机制的认识。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Combination of 5-FU and IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines
5-FU 与 IFNα 联合增强 IFN 信号通路和 caspase-8 活性,导致肝癌细胞系显着凋亡
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Koike;K.;Takaki;A.;Tatsukawa;M.;Suzuki;M.;Shiraha;H.;Iwasaki;Y.;Sakaguchi;K.;Shiratori;Y
- 通讯作者:Y
Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration.
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Tatsuya Fujikawa;H. Shiraha;N. Ueda;N. Takaoka;Y. Nakanishi;Noriyuki Matsuo;Shigetomi Tanaka;Shin-ichi Nishina;Mayumi Suzuki;A. Takaki;K. Sakaguchi;Y. Shiratori
- 通讯作者:Tatsuya Fujikawa;H. Shiraha;N. Ueda;N. Takaoka;Y. Nakanishi;Noriyuki Matsuo;Shigetomi Tanaka;Shin-ichi Nishina;Mayumi Suzuki;A. Takaki;K. Sakaguchi;Y. Shiratori
Combination of 5-FU IFNalpha enhances IFN signaling pathway and caspase-8 activity, resulting in marked apoptosis in hepatoma cell lines.
5-FU IFNα 组合可增强 IFN 信号通路和 caspase-8 活性,导致肝癌细胞系显着凋亡。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Koike K;Takaki A;et al.
- 通讯作者:et al.
Short-term high-dose followed by long-term low-dose HBIG and lamivudinepreventedrecurrenthepatitisBafter liver transplantation.
短期大剂量继长期低剂量HBIG和拉米夫定可预防肝移植后B型肝炎复发。
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Takaki A;Yagi T;et al.
- 通讯作者:et al.
Endoscopic therapy for bleeding esophageal varices improves the outcome of Child C cirrhotic patients
- DOI:10.1111/j.1440-1746.2006.04267.x
- 发表时间:2006-11-01
- 期刊:
- 影响因子:4.1
- 作者:Hori, Shinichiro;Takaki, Akinobu;Shiratori, Yasushi
- 通讯作者:Shiratori, Yasushi
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TAKAKI Akinobu其他文献
TAKAKI Akinobu的其他文献
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{{ truncateString('TAKAKI Akinobu', 18)}}的其他基金
To develop a new immune therapy for post liver transplantation hepatitis C.
开发针对肝移植后丙型肝炎的新免疫疗法。
- 批准号:
22590735 - 财政年份:2010
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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