HLA class II polymorphism and worldwide susceptibility to optico-spinal multiple sclerosis.

HLA II 类多态性和全球视神经脊髓多发性硬化症的易感性。

• 批准号: 17590881
• 负责人: MINOHARA Motozumi
• 金额: $ 2.24万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590881/
• 关键词: multiple sclerosis; optico-spinal MS; HLA-class II; LESCL; MRI; NMO; China; Brazil; 視神経脊髄型; HLA; EAE

Multiple sclerosis (MS) is currently hypothesized to be mediated by autoreactive T cells against myelin antigens. In Japanese, MS frequently and selectively affects the optic nerve and spinal cord. We have previously reported that susceptibility to the conventional multiple sclerosis (CMS) is associated with the HLA-DRB1^*1501-DRB5^*0101 haplotype while susceptibility to the optico-spinal MS (OSMS) is associated with HLA-DPA1^*0202-DPB1^*0501. We studied HLA-DRB1 and-DPB1 polymorphisms in 34 Chinese patients with MS (CMS;21,OSMS+NMO;13) and 35 Brazilian NMO patients. We did not find any association of HLA alleles with disease due to the small sample size.Furthermore, we analyzed to determine HLA class II gene alleles associated with the development of characteristic MRI findings in Japanese MS patients (CMS;71,OSMS;50). The patients were firstly classified by the presence or absence of brain lesions fulfilling the Barkhof criteria and then by the presence or absence of LESCLs into four groups ; Barkhof(+) LESCL(+), Bakhof(+) LESCL(-), Barkhof(-) LESCL(+) and Barkhof(-) LESCL(-). The Barkhof (-) patients had markedly lower frequency of HLA-DRB1^*0901 than the controls (HC 28.3% vs. Total MS 8.3%, P^<corr> <0.05) while that of DRB1^*1501 was increased in the Barkhof (+) group (HC 15.0% vs.Barkhof(+) MS 30.0%, P^<uncorr><0.05). The Barkhof(-) LESCL(-) group showed a significant increase of DRB1^*0405,compared with the controls (HC 26.7% vs.Barkhof(-)/LESCL(-)MS 62.5%, P^<corr><0.05). The frequency of the DPB1^* 0501 allele was highest in the Barkhof(-) LESCL(+) group (HC 62.5% vs.Barkhof(-)/LESCL(+) MS 79.3%, P^<uncorr><0.05). Characteristic MRI features in Japanese MS patients are partly related to the distinct HLA-class II gene alleles.

多发性硬化症(MS)目前被认为是由抗髓鞘抗原的自身反应性T细胞介导的。在日本，多发性硬化症经常和选择性地影响视神经和脊髓。我们曾报道，对传统多发性硬化症(CMS)的易感性与人类白细胞抗原DRB1^*1501-DRB5^*0101单倍型有关，而对视神经脊髓型多发性硬化症(OSMS)的易感性与人类白细胞抗原-DPA1^*0202-DPB1^*0501相关。我们研究了34例中国MS患者(CMS；21例，OSMS+NMO；13例)和35例巴西NMO患者的HLA-DRB1和-DPB1基因多态性。由于样本量较小，我们没有发现任何与疾病相关的HLA等位基因。此外，我们分析了与日本MS患者(CMS；71，OSM；50)的特征性MRI表现的发展相关的HLAII类基因等位基因。根据有无符合Barkhof标准的脑部病变将患者分为4组：Barkhof(+)LESCL(+)组、Bakhof(+)LESCL(-)组、Barkhof(-)LESCL(+)组和Barkhof(-)LESCL(-)组。Barkhof(-)组HLADRB1^*0901频率显著低于对照组(HC 28.3%vs.Total MS 8.3%，P^lt；corr&gt；&lt；0.05)，而DRB1^*1501频率在Barkhof(+)组升高(HC 15.0%vs.Barkhof(+)MS 30.0%，P^lt；uncorr&lt；Barkhof(-)LESCL(-)组DRB1*0405显著高于对照组(HC 26.7%vs.Barkhof(-)/LESCL(-)MS 62.5%，P^&lt；corr&gt；&lt；0.05)。DPB1^*0501等位基因频率在Barkhof(-)LESCL(+)组中最高(HC 62.5%vs.Barkhof(-)/LESCL(+)MS 79.3%，P^&lt；uncorr&gt；&lt；0.05)。日本多发性硬化症患者的特征性MRI表现部分与不同的人类白细胞抗原II类基因等位基因有关。

项目成果

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomyelitis

选择性 Rho 激酶抑制剂 Fasudil 对实验性过敏性脑脊髓炎具有保护和治疗作用

• 发表时间: 2006
• 期刊: J Neuroimmunol 180
• 作者: Sun X;Minohara M;Kikuchi S;Ishizu T;Tanaka M;Piao H;Osoegawa M;Ohyagi Y;Shimokawa H;Kira J
• 通讯作者: Kira J

Th2 shift in juvenile muscular atrophy of distal upper extremity : a combined allergological and flow cytometric analysis

青少年上肢远端肌萎缩症的Th2转变：过敏学和流式细胞分析相结合

• 发表时间: 2005
• 期刊: J Neurol Sci 228
• 作者: Fujio Umehara;Kenichi Mishima;Nobuaki Egashira;Ayumi Ogata;Katsunori Iwasaki;Michihiro Fujiwara.;Ward V;Osoegawa M et al.
• 通讯作者: Osoegawa M et al.

Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis

日本多发性硬化症患者对干扰素 β-1b 的长期良好反应与细胞因子偏向 Th2 和 Tc2 侧有关

• 发表时间: 2006
• 期刊: J Neurol Sci 246
• 作者: Mei F-J;Osoegawa M;Ochi H;Minohara M;Shi N;Murai H;Ishizu T;Taniwaki T;Kira J
• 通讯作者: Kira J

Helicobacter pyoli infection is a potential protective factor against conventional multiple sclerosis in the Japanese population.

幽门螺杆菌感染是日本人群预防传统多发性硬化症的潜在保护因素。

• 发表时间: 2007
• 期刊: J Neuroimmunol 184
• 作者: Yamashita H;et al.;田中恵子;Li W et al.
• 通讯作者: Li W et al.

Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings

• DOI: 10.1016/j.jns.2005.11.006
• 发表时间: 2006-04-15
• 期刊: JOURNAL OF THE NEUROLOGICAL SCIENCES
• 影响因子: 4.4
• 作者: Su, JJ;Osoegawa, M;Kira, J
• 通讯作者: Kira, J