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Genetic and environmental Analysis of Panic Disorder

恐慌症的遗传和环境分析

基本信息

批准号：
17591195
负责人：
UMEKAGE Tadashi
金额：
$ 2.24万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

1. Collection of blood samples from patients with Panic DisorderWith a multi-center collaborative effort, we collected 1000 blood samples for the genetic analysis of Panic Disorder, mainly from the Research Center for Anxiety Disorder, Warakukai.2. Genetic and environmental Analysis of Panic Disorder(1) The association of Neuroticism with the DRD4 gene and the XBP1 gene in Japanese subjects was observed. Lifestyle factors such as a like/dislike of physical exercise and environmental factors including weather conditions were found to be associated with the development of Panic Disorder. We observed no association between polymorphisms in the Circadian Clock genes (Per3, CK1 ε, CLO) with Panic Disorder.(2) To define the candidate region related to Panic Disorder, a genome-wide association study (200 cases and 100 controls) was performed using 500K SNP Tips by Prof.Okazaki (Director of Tokyo Metropolitan Matsuzawa Hospital). By analyzing the candidate region of chromosome 1, we found the PDE4B gene and the SYT2 gene may be associated with Panic Disorder.

1. 恐慌症患者血样的采集经过多中心协作，主要来自和乐会焦虑症研究中心，采集了1000份血样用于恐慌症基因分析。 2．恐慌症的遗传和环境分析(1)观察日本受试者神经质与DRD4基因和XBP1基因的关联。研究发现生活方式因素（例如喜欢/不喜欢体育锻炼）和环境因素（包括天气条件）与恐慌症的发展有关。我们观察到昼夜节律时钟基因（Per3、CK1ε、CLO）的多态性与恐慌症之间没有关联。(2) 为了确定与恐慌症相关的候选区域，冈崎教授（东京都松泽医院院长）使用 500K SNP Tips 进行了全基因组关联研究（200 个病例和 100 个对照）。通过分析1号染色体的候选区域，我们发现PDE4B基因和SYT2基因可能与恐慌症相关。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits.

促肾上腺皮质激素释放激素受体 2 (CRHR2) 基因多态性与人格特征之间的关联。

DOI：
发表时间：
2006
期刊：
Psychiatry Clin Neurosci. 60(4)
影响因子：
0
作者：
Porgpermdee S;et al;Lee HG et al.;Tochigi M
通讯作者：
Tochigi M

Factors associated with the development of panic attack and panic disorder : survey in the Japanese population.

与惊恐发作和惊恐障碍发生相关的因素：对日本人群的调查。

DOI：
发表时间：
2005
期刊：
Psychiatry Clin Neurosci. 59(2)
影响因子：
0
作者：
Chen X;Niyonsaba F;Ushio H;Nagaoka I;Ikeda S;et al.;車地暁生;Fang YR;Suzuki Y;Kaiya H
通讯作者：
Kaiya H

Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'

DOI：
10.1111/j.1440-1819.2005.01404.x
发表时间：
2005-08-01
期刊：
PSYCHIATRY AND CLINICAL NEUROSCIENCES
影响因子：
11.9
作者：
Kazuno, AA;Munakata, K;Kato, T
通讯作者：
Kato, T

Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes

DOI：
10.1016/j.neures.2005.11.003
发表时间：
2006-03
期刊：
Neuroscience Research
影响因子：
2.9
作者：
Mamoru Tochigi;Takeshi Otowa;H. Hibino;Chieko Kato;Toshiyuki Otani;T. Umekage;T. Utsumi;N. Kato;Tsukasa Sasaki
通讯作者：
Mamoru Tochigi;Takeshi Otowa;H. Hibino;Chieko Kato;Toshiyuki Otani;T. Umekage;T. Utsumi;N. Kato;Tsukasa Sasaki

No association of 5-HT2C, 5-HTG, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population.

5-HT2C、5-HTG 和色氨酸羟化酶-1 基因多态性与日本人群的人格特征没有关联。