Examination of high-resolution MRI and MR spectroscopy evaluating therapieutic effect of radiation therapy and chemotherapy in animal model.

我们评价了高分辨率MRI和~1H-MRS在评价放化疗对兔VX2肿瘤治疗效果中的作用。建立兔大腿VX2肿瘤模型，分别于放疗前、放疗后3d、放疗后1周、放疗后2周行MRI和1H-MRS检查。经放射后MRI和~1H-MRS检查后，于各时间点处死动物进行组织病理学检查，高分辨MRI表现与组织病理学对照，但不能用高分辨MRI评价肿瘤的早期坏死。在1H-MRS上，肿瘤坏死早期乳酸/肌酸比值升高，提示1H-MRS对VX2肿瘤化疗和放疗后早期坏死的评价优于高分辨率MRI，1H-MRS可能更早地评价疗效。

We assessed the role of the high-resolution MRI and ^1H-MRS evaluating the therapieutic effect of chemotherapy and radiation therapy for VX2 carcinoma in rabbits. The rabbits with VX2 carcinoma in the thigh were underwent MRI and ^1H-MRS at before, 3 days, 1 week, and 2 weeks after 30Gy irradiation and one shot chemotherapy. After taking postirradiation MRI and ^1H-MRS, rabbits were killed for histopathologic examination at each time interval.The high-resolution MRI findings were correlated with the histopathological findings, however, the early stage of necrosis of tumor was not able to evaluate using the high-resolution MRI. On ^1H-MRS, the ratio of lactate / creatine was elevated in the early stage of necrosis of tumor.It was suggested that ^1H-MRS was superior to high-resolution MRI evaluating the early stage of necrosis of VX2 carcinoma post chemotherapy and radiation therapy.The ^1H-MRS might be superior evaluating the therapieutic effects earlier.