Quantiaitive assessment of biomarker imaging for early threapeutic response to chemoradiotherapy

探讨弥散加权MRI的表观扩散系数（ADC）和FDG PET-CT的标准化摄取值（SUV）在预测和早期发现头颈部鳞状细胞癌（HNSCC）放化疗的治疗反应和患者预后中的作用。治疗前和治疗3周期间ADC的微小变化与治疗反应和患者预后有显著相关性。此外，治疗前与治疗8周后SUVmax的变化与患者预后有显著相关性。结果提示，ADC的分数变化和SUVmax的变化是预测HNSCC放化疗治疗反应和患者预后的有效成像生物标志物。

The efficacy of apparent diffusion coefficient (ADC) of diffusion weighted MRI and standardized uptake value (SUV) of FDG PET-CT for prediction and early detection of treatment response and patient outcome to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC) was investigated.The fractional changes in ADC between pre-treatment and during 3 weeks of treatment showed significant correlation with treatment response and patient outcome. In addition, the changes in SUVmax between pre-treatment and after 8weeks of treatment showed significant correlation with patinet outcome. The results suggest that the fractional changes in ADC and the changes in SUVmax are valid imaging biomarker for predicting treatment response and patinet outcome in HNSCC treated with chemoradiotherapy.