Quantiaitive assessment of biomarker imaging for early threapeutic response to chemoradiotherapy

本文研究了头颈部鳞癌（HNSCC）的磁共振弥散加权成像（MRI）的表观弥散系数（ADC）和正电子发射断层扫描（PET-CT）的标准化摄取值（SUV）在预测和早期检测放化疗疗效和患者预后中的作用。此外，治疗前和治疗8周后SUVmax的变化与患者预后显著相关。结果提示，ADC值和SUVmax的变化是预测放化疗后HNSCC疗效和预后的有效影像学指标。

The efficacy of apparent diffusion coefficient (ADC) of diffusion weighted MRI and standardized uptake value (SUV) of FDG PET-CT for prediction and early detection of treatment response and patient outcome to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC) was investigated.The fractional changes in ADC between pre-treatment and during 3 weeks of treatment showed significant correlation with treatment response and patient outcome. In addition, the changes in SUVmax between pre-treatment and after 8weeks of treatment showed significant correlation with patinet outcome. The results suggest that the fractional changes in ADC and the changes in SUVmax are valid imaging biomarker for predicting treatment response and patinet outcome in HNSCC treated with chemoradiotherapy.