Examination Study on Development and Evaluation of Ceramics in Medicine through Control of Nano-interface

患有硬组织疾病的患者数量迅速增加，鉴于当今社会的人口趋势，老年人数量众多；这是一个具有严重财政影响的重要全球问题。羟基磷灰石（hydroxyapite, HAp）陶瓷可直接与宿主骨结合，是新一代优秀的生物活性材料之一；然而，羟基磷灰石也存在一些问题，如缺乏骨诱导能力和相对较差的力学性能与天然骨相比。为了克服上述问题，为老年人提供高质量的生活，我们计划通过纳米界面的控制来开发新型、高性能的生物材料。首先，我们在2005年通过纳米界面的控制对陶瓷在医学上的发展和评价进行了考察研究，包括参考文献。因此，我们提出了“磷灰石基因组学”的概念，即磷灰石陶瓷通过控制磷灰石陶瓷与细胞之间的纳米界面来影响细胞（如成骨细胞和破骨细胞）的基因表达。我们相信这一概念将创造出具有高性能的新型生物材料。此外，我们还于2005年9月28日至29日在大阪举办的日本陶瓷学会秋季会议上组织了“通过控制纳米界面来开发和评价陶瓷在医学上的应用”的会议，并在日本生物材料学会杂志上发表了我们的评论。

There is a rapidly increasing number of patients with diseases of their hard-tissue and, given current demographic trends in today's society with a large number of elderly people ; this is an important global problem with severe financial implications.In general, hydroxyaptite (HAp) ceramcis, which bonds directly with host bone, is one of a new generation of excellent bioactive materials ; however, HAp has some problems, such as lack of osteoinductivity and relatively inferior mechanical properties as compared with natural bone. In order to overcome the above problems and to provide a high quality of life (QOL) for the aged, we plan to develop novel, high performance biomaterials though control of nano-interface.Firstly, we performed the examination study on the development and evaluation of ceramics in medicine through control of nano-interface at 2005 including a bibliography. Thus, we have arrived at a concept of "apatite genomics" which the apatite ceramics give an affect to gene expression of cells, such as osteoblast and osteoclasts, based on control of nano-interface between HAp ceramics and cells. We believe that this concept create novel biomaterials with high-performance properties.In addition, we have organized a session "the development and evaluation of ceramics in medicine through control of nano-interface" of 18^<th> Fall Meeting of The Ceramic Society of Japan at the 28^<th>-29^<th> September 2005 in Osaka, and then our reviews have been published to Journal of Japanese Society for Biomaterials.