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Examination Study on Development and Evaluation of Ceramics in Medicine through Control of Nano-interface

纳米界面控制医药陶瓷开发与评价的检验研究

基本信息

批准号：
17630008
负责人：
AIZAWA Mamoru
金额：
$ 2.11万
依托单位：
Meiji University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17630008/
关键词：
Biomaterials Bioceramics Nano-structure Control of nano-interface Inorganic organic Hybrid Cellular Response Tissue Reaction in vivo Quality of Life (QOL)

项目摘要

There is a rapidly increasing number of patients with diseases of their hard-tissue and, given current demographic trends in today's society with a large number of elderly people ; this is an important global problem with severe financial implications.In general, hydroxyaptite (HAp) ceramcis, which bonds directly with host bone, is one of a new generation of excellent bioactive materials ; however, HAp has some problems, such as lack of osteoinductivity and relatively inferior mechanical properties as compared with natural bone. In order to overcome the above problems and to provide a high quality of life (QOL) for the aged, we plan to develop novel, high performance biomaterials though control of nano-interface.Firstly, we performed the examination study on the development and evaluation of ceramics in medicine through control of nano-interface at 2005 including a bibliography. Thus, we have arrived at a concept of "apatite genomics" which the apatite ceramics give an affect to gene expression of cells, such as osteoblast and osteoclasts, based on control of nano-interface between HAp ceramics and cells. We believe that this concept create novel biomaterials with high-performance properties.In addition, we have organized a session "the development and evaluation of ceramics in medicine through control of nano-interface" of 18^<th> Fall Meeting of The Ceramic Society of Japan at the 28^<th>-29^<th> September 2005 in Osaka, and then our reviews have been published to Journal of Japanese Society for Biomaterials.

随着硬组织疾病患者数量的迅速增加，以及当今社会人口老龄化的趋势，这是一个重要的全球性问题，并带来严重的经济影响。羟基磷灰石（HAp）陶瓷是新一代优良的生物活性材料之一，可直接与宿主骨结合，具有良好的生物相容性。然而，HAp存在一些问题，如缺乏骨诱导性和与天然骨相比相对较差的机械性能。为了克服上述问题，为老年人提供高质量的生活（QOL），我们计划通过纳米界面的控制来开发新型的、高性能的生物材料。首先，我们在2005年进行了通过纳米界面控制的医学陶瓷的开发和评价的检查研究，包括参考文献。因此，我们已经达到了“磷灰石基因组学”的概念，即磷灰石陶瓷基于HAp陶瓷与细胞之间的纳米界面的控制而影响细胞（如成骨细胞和破骨细胞）的基因表达。我们相信这一概念创造了具有高性能的新型生物材料。此外，我们还在2005年9月28日至29日在大坂举行的日本陶瓷学会第18届秋季会议上组织了一次会议“通过控制纳米界面开发和评估医学陶瓷”<th><th><th>，然后我们的评论发表在日本生物材料学会杂志上。