Examination Study on Development and Evaluation of Ceramics in Medicine through Control of Nano-interface

目前，硬组织疾病的患者数量迅速增加，在当今老年人口众多的社会，这是一个重要的全球性问题，具有严重的经济影响。总的来说，直接与宿主骨结合的羟基磷灰石(HAP)陶瓷是新一代优良的生物活性材料之一，但HAP存在一些问题，如缺乏成骨诱导活性，与天然骨相比力学性能相对较差。为了克服上述问题，为老年人提供高质量的生活质量，我们计划通过控制纳米界面来开发新型、高性能的生物材料。首先，我们在2005年进行了纳米界面控制在医学上的陶瓷开发和评价的试验性研究，包括参考文献。因此，我们提出了磷灰石基因组学的概念，即通过调控羟基磷灰石陶瓷与细胞之间的纳米界面来影响成骨细胞和破骨细胞等细胞的基因表达。我们相信，这一概念创造了具有高性能性能的新型生物材料。此外，我们还在2005年9月28日至29日在大阪举办的日本陶瓷学会第18届秋季会议上组织了一场名为《通过纳米界面控制在医学上对陶瓷的开发与评价》的会议，并将研究成果发表在《日本生物材料学会杂志》上。

There is a rapidly increasing number of patients with diseases of their hard-tissue and, given current demographic trends in today's society with a large number of elderly people ; this is an important global problem with severe financial implications.In general, hydroxyaptite (HAp) ceramcis, which bonds directly with host bone, is one of a new generation of excellent bioactive materials ; however, HAp has some problems, such as lack of osteoinductivity and relatively inferior mechanical properties as compared with natural bone. In order to overcome the above problems and to provide a high quality of life (QOL) for the aged, we plan to develop novel, high performance biomaterials though control of nano-interface.Firstly, we performed the examination study on the development and evaluation of ceramics in medicine through control of nano-interface at 2005 including a bibliography. Thus, we have arrived at a concept of "apatite genomics" which the apatite ceramics give an affect to gene expression of cells, such as osteoblast and osteoclasts, based on control of nano-interface between HAp ceramics and cells. We believe that this concept create novel biomaterials with high-performance properties.In addition, we have organized a session "the development and evaluation of ceramics in medicine through control of nano-interface" of 18^<th> Fall Meeting of The Ceramic Society of Japan at the 28^<th>-29^<th> September 2005 in Osaka, and then our reviews have been published to Journal of Japanese Society for Biomaterials.