Dissection of CrRLK1L signalling pathways regulating disease susceptibility and resistance to powdery mildew
CrRLK1L 信号通路调控疾病易感性和白粉病抗性的剖析
基本信息
- 批准号:465669230
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:2021
- 资助国家:德国
- 起止时间:2020-12-31 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
CATHARANTHUS ROSEUS RECEPTOR-LIKE KINASE 1-LIKE (CrRLK1L) proteins are important receptors controlling diverse physiological responses. Together with its endogenous RAPID ALKALINISATION FACTOR (RALF) peptide ligands, the CrRLK1L FERONIA (FER) plays central roles during plant growth, development and immunity. FER is a positive regulator of pattern-triggered immunity (PTI) and antibacterial resistance by facilitating the formation of ligand-induced microbe-associated molecular pattern (MAMP) recognition complexes in a RALF peptide-dependent manner. By contrast, FER functions as a susceptibility factor during powdery mildew infection and the underlying mechanism for FER`s role during diverse plant microbe interactions remains unknown. We show that other known FER signalling components modulate plant powdery mildew accommodation, suggesting that RALF-FER represents a pathway hijacked by adapted powdery mildew fungi. Here, we will analyse the mechanistic basis of FER during powdery mildew susceptibility and dissect signalling pathways distinguishing its functional diversity during antibacterial resistance. THESEUS1 (THE1) is a CrRLK1L related to FER but plays a positive role in basal resistance to powdery mildew, suggesting that the repertoire of CrRLK1Ls determine positive and negative infection outcomes. We will explore the functional diversity of Arabidopsis CrRLK1Ls to elucidate the molecular mechanisms that result in disease susceptibility or resistance. FER and related CrRLK1Ls are conserved among all land plants with likely similar functions across species. Barley has six close FER homologs, suggesting that the protein diversified and raising the hypothesis that individual barley homologs take over specific roles of the multifunctional Arabidopsis protein during distinct plant microbe interactions. We want to explore the functional diversity of FER in barley to generate transferable knowledge for future crop improvement strategies.
长春花受体样激酶1样蛋白(CrRLK 1 L)是调控多种生理反应的重要受体。CrRLK 1 L FERONIA(FER)与其内源性快速碱化因子(RALF)肽配体一起,在植物生长、发育和免疫过程中发挥重要作用。FER是模式触发免疫(PTI)和抗菌药物耐药性的正调节因子,通过RALF肽依赖性方式促进配体诱导的微生物相关分子模式(MAMP)识别复合物的形成。相比之下,FER在白粉病感染期间作为易感因子发挥作用,并且FER在不同植物微生物相互作用期间的作用的潜在机制仍然未知。我们发现,其他已知的FER信号成分调节植物白粉病的住宿,这表明RALF-FER代表了适应白粉病真菌劫持的途径。在这里,我们将分析FER在白粉病易感性和解剖信号通路区分其功能多样性在抗菌药物抗性的机制基础。THESEUS 1(THE 1)是与FER相关的CrRLK 1 L,但在对白粉病的基础抗性中起积极作用,这表明CrRLK 1 Ls的库决定阳性和阴性感染结果。我们将探索拟南芥CrRLK 1 Ls的功能多样性,以阐明导致疾病易感性或抗性的分子机制。FER和相关的CrRLK 1 Ls在所有陆地植物中是保守的,在不同物种之间可能具有相似的功能。大麦有六个密切的FER同源物,这表明蛋白质多样化,并提出了一个假设,即个别大麦同源物在不同的植物微生物相互作用过程中接管多功能拟南芥蛋白质的特定作用。我们希望探索FER在大麦中的功能多样性,为未来的作物改良策略提供可转移的知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dr. Martin Stegmann其他文献
Dr. Martin Stegmann的其他文献
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{{ truncateString('Dr. Martin Stegmann', 18)}}的其他基金
MOB proteins as novel regulators of pathogen-associated molecular pattern-triggered immunity in Arabidopsis thaliana
MOB 蛋白作为拟南芥病原体相关分子模式触发免疫的新型调节剂
- 批准号:
271734448 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Research Fellowships
Coordination of plant immunity and abiotic stress by CEP peptides
CEP 肽协调植物免疫和非生物胁迫
- 批准号:
450044414 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Grants
相似国自然基金
抗腐烂病苹果CrRLK1L基因鉴定及其调控机制研究
- 批准号:31860545
- 批准年份:2018
- 资助金额:41.0 万元
- 项目类别:地区科学基金项目
相似海外基金
Dissection of CrRLK1L signalling pathways regulating disease susceptibility and resistance to powdery mildew (B09)
CrRLK1L信号通路调控疾病易感性和白粉病抗性的剖析(B09)
- 批准号:
518022653 - 财政年份:
- 资助金额:
-- - 项目类别:
CRC/Transregios