Action mechanisms and roles of small GTP-binding proteins

小 GTP 结合蛋白的作用机制和作用

基本信息

  • 批准号:
    05271103
  • 负责人:
  • 金额:
    $ 111.87万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
  • 财政年份:
    1993
  • 资助国家:
    日本
  • 起止时间:
    1993 至 1995
  • 项目状态:
    已结题

项目摘要

RhoA and PKC activate synergistically the membrane-bound phospholipase D (PLD) in HL60. The Toxin B and C3 toxin treatments show involvement of CDC42 in PLD activation in RBL cells. PLD cDNAs were cloned from rat (Nozawa). (2) Rhabphilin-3A binds to synaptic vesicles via anchoring protein. A newly identified homolog Doc regulates exocytosis. A target protein of Rho1 is PKC in budding yeast (Takai). (3) Target proteins of Rho are PKN and p160^<PRCK>, rhophilin, rhotekin and citron. PKN and p160^<PRCK> are activated by GTP/Rho (Narumiya). (4) Expression of RhoA and RhoGDI decreases with age in rat prostate. The 20 kDa protein (H3 histone) is ADP-ribosylated (Ishibashi). (5) A factore inbolved in Raf1 activation is identified to be 14-3-3. A MAP kinase kinase (TAK1) acts in TGF-beta signaling (Matumoto). (6) Sar1p and E112K participate in vesicle transport between endoplasm reticulum and Golgi body in yeast. SAR1 from tobacco rescues SAR1 defective mutant of yeast (Nakano). (7) A arginine-specific ADP-ribosyl transferase cloned from chiken PMN ADP-ribosylates Arg^<28> in actin (Shimoyama). (8) A novel inhibitor (CKB-1055) inhibits S6 kinase in insulin signaling and exerts insulin-like action in glycogen metabolism (Hidaka.) (9) PLA_2 inhibitor blocks fusion of Golgi bodies and vesicles leading to inhibition of secretion. Brefeldin blocks vesicle formation (Ikehara). (10) Gene expression of thymidine transports greatly repressed in DnaA defective mutant of E.coli. (Sekimizu).
RhoA和PKC协同激活HL60的膜结合磷脂酶D (PLD)。毒素B和C3毒素处理表明CDC42参与了RBL细胞PLD的激活。从大鼠(Nozawa)克隆PLD cdna。(2) Rhabphilin-3A通过锚定蛋白与突触囊泡结合。一种新发现的同系物Doc调节胞吐。Rho1的靶蛋白是出芽酵母中的PKC。(3) Rho的靶蛋白为PKN和p160^<PRCK>、rhotekin、rhotekin和citron。PKN和p160^<PRCK>被GTP/Rho (Narumiya)激活。(4)大鼠前列腺中RhoA和RhoGDI的表达随年龄的增长而降低。20 kDa蛋白(H3组蛋白)被adp核糖化(Ishibashi)。(5)鉴定出一个参与Raf1激活的因子为14-3-3。MAP激酶激酶(TAK1)在tgf - β信号传导中起作用。(6)酵母中Sar1p和E112K参与了内质网与高尔基体之间的囊泡运输。来自烟草的SAR1拯救了酵母SAR1缺陷突变体(中野)。(7)鸡PMN adp -核糖基转移酶Arg^<28> (Shimoyama)。(8)一种新的抑制剂(CKB-1055)抑制胰岛素信号通路中的S6激酶,并在糖原代谢中发挥胰岛素样作用(Hidaka.)(9) PLA_2抑制剂阻断高尔基体与囊泡的融合,抑制高尔基体的分泌。布雷菲尔丁阻断囊泡形成(Ikehara)。(10)大肠杆菌dna缺陷突变体胸苷转运基因表达受到抑制。(Sekimizu)。

项目成果

期刊论文数量(154)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kurokawa T.: "Reduction of mono(ADP-ribosyl)ation of histones in rat testis by gonadotropin-testosterone system" Biochem. Biophys. Res. Commun.215. 808-815 (1995)
Kurokawa T.:“促性腺激素-睾酮系统减少大鼠睾丸中组蛋白的单(ADP-核糖基)化”Biochem。
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    0
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Sato,E.: "Eraly changes in glucose metabolism in the cerebrum of senescence accelerated mouse." Brain Res.637. 133-138 (1994)
Sato,E.:“小鼠大脑中葡萄糖代谢的早期变化加速了小鼠的衰老。”
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    0
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Takano,Y.: "Role of cytoplasmic tail phosphorylation sites of platelet-activating factor receptor in agonist-induced desensitization." J.Biol.Chem.269. 22453-22458 (1994)
Takano,Y.:“血小板激活因子受体细胞质尾部磷酸化位点在激动剂诱导的脱敏中的作用。”
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    0
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Okimoto,T.: "Brefeldin A protects ricin-induced cytotoxicity in human cancer KB cell line,but not in its resistant counterpart with altered Golgi structures." Cell Struct.Funct.18. 241-251 (1993)
Okimoto, T.:“布雷菲德菌素 A 可以保护人类癌症 KB 细胞系中蓖麻毒素诱导的细胞毒性,但不能保护高尔基体结构改变的耐药细胞系。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Watanabe,T.: "Reduction of mono(ADP-ribosyl)action of histones in rat testis by gonadotropin-testosterone system" Science. 271. 645-648 (1995)
Watanabe,T.:“促性腺激素-睾酮系统减少大鼠睾丸中组蛋白的单(ADP-核糖基)作用”科学。
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  • 影响因子:
    0
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NOZAWA Yoshinori其他文献

NOZAWA Yoshinori的其他文献

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{{ truncateString('NOZAWA Yoshinori', 18)}}的其他基金

REGULATORY MECHANISM BY PHOSPHOLIPASE D IN OXIDANT-STRESS INDUCED SURVIVAL SIGNALING
氧化应激诱导的生存信号传导中磷脂酶 D 的调节机制
  • 批准号:
    16390098
  • 财政年份:
    2004
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
CROSS-TALK OF MEMBRANE LIPID SIGNALING IN CELL DEATH AND SURVIVAL
细胞死亡和存活中膜脂信号传导的交叉对话
  • 批准号:
    14370064
  • 财政年份:
    2002
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
MECHNISM OF APOPTOSIS INDUCED BY MEMBRANE LIPID SYGNALING
膜脂信号诱导细胞凋亡的机制
  • 批准号:
    12470042
  • 财政年份:
    2000
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional analysis of the new signal transduction enzyme PLD by the molecular genetic technique
分子遗传学技术分析新型信号转导酶PLD的功能
  • 批准号:
    10212204
  • 财政年份:
    1998
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas (B)
Molecular mechanisms for regulation and physiological role of phospholipase D
磷脂酶D调节的分子机制和生理作用
  • 批准号:
    09480162
  • 财政年份:
    1997
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Molecular mechanisms for membrane lipid signaling in apoptosis
细胞凋亡中膜脂信号传导的分子机制
  • 批准号:
    07457036
  • 财政年份:
    1995
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Studies on Functions of bioactive phospholipids
生物活性磷脂的功能研究
  • 批准号:
    06304050
  • 财政年份:
    1994
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.
ras相关低Mr GTP结合蛋白的构象和功能研究。
  • 批准号:
    03304052
  • 财政年份:
    1991
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for Co-operative Research (A)
Interaction of multiple phospholipase C and GTP-binding proteins in platelet signal transduction
多种磷脂酶 C 和 GTP 结合蛋白在血小板信号转导中的相互作用
  • 批准号:
    02454544
  • 财政年份:
    1990
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Adaptation mechanism of membrane lipids and its genetic control
膜脂适应机制及其遗传调控
  • 批准号:
    61480465
  • 财政年份:
    1986
  • 资助金额:
    $ 111.87万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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Synaptic vesicle transport revealed by electrophysiological and imaging studies
电生理学和成像研究揭示突触小泡运输
  • 批准号:
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    2019
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Mechanism and function of mitochondrial derived vesicle transport to peroxisomes.
线粒体来源的囊泡转运至过氧化物酶体的机制和功能。
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    390031
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Runx1 单倍体缺陷、内吞作用和囊泡运输
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肌动蛋白/肌球蛋白在细胞内囊泡转运过程中的功能
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阐明四跨膜蛋白和囊泡运输在淋巴平滑肌瘤病肿瘤进展中的作用。
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