Molecular mechanisms of immune regulation.

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To elucidate the molecular mechanisms of immune regulation in immune response to natural antigens in individuals, we investigated the recognition of HLA/peptide complexes by TCRs and the resultant cytokine expressions induced by interaction with the TCR.1.We elucidated the immune regulation by HLA-class I and Class II molecules by examining the genetic association between immune responses and HLA.2.We identified allergenic peptides that bind to HLA molecules and found that IgE production is inhibited by catepsin B.3.We elucidated the differences in HLA A bound motifs between alleles that are or are not associated with high frequencies of autoimmune disease susceptibility.4.We established monoclonal antibodies against a monocyte-specific antigen encoded by a gene that maps to the HLA region.5.We cloned proteosome and associated genes which are involved in the production of antigenic peptides.6.We found that Valpha14 TCR is necessary for NKT cell differentiation.7.We found new aspects of the relationship between gammadeltaT cell proliferation and GvH reactions.8.We found different transcription factors are used for Th1 and Th2 cytokine genes expression.9.We found a new soluble factor involved in the suppression of antibody production.