Molecular mechanisms of immune regulation.

为了阐明个体对天然抗原免疫应答中免疫调节的分子机制，我们研究了TCR对HLA/肽复合物的识别，以及与TCR相互作用诱导的细胞因子表达。通过检测免疫应答和HLA之间的遗传关联，我们鉴定了与HLA结合的变应原性肽分子，并发现IgE的产生被catepsin B抑制。3.我们阐明了与自身免疫性疾病易感性高频率相关或不相关的等位基因之间HLA A结合基序的差异。5.我们克隆了蛋白体和相关基因，这些基因与抗原的产生有关，7.我们发现了γ δ T细胞增殖与GvH反应之间关系的新方面; 8.我们发现了不同的转录因子用于Th 1和Th 2细胞因子基因的表达; 9.我们发现了一种新的可溶性因子参与抑制抗体的产生。

To elucidate the molecular mechanisms of immune regulation in immune response to natural antigens in individuals, we investigated the recognition of HLA/peptide complexes by TCRs and the resultant cytokine expressions induced by interaction with the TCR.1.We elucidated the immune regulation by HLA-class I and Class II molecules by examining the genetic association between immune responses and HLA.2.We identified allergenic peptides that bind to HLA molecules and found that IgE production is inhibited by catepsin B.3.We elucidated the differences in HLA A bound motifs between alleles that are or are not associated with high frequencies of autoimmune disease susceptibility.4.We established monoclonal antibodies against a monocyte-specific antigen encoded by a gene that maps to the HLA region.5.We cloned proteosome and associated genes which are involved in the production of antigenic peptides.6.We found that Valpha14 TCR is necessary for NKT cell differentiation.7.We found new aspects of the relationship between gammadeltaT cell proliferation and GvH reactions.8.We found different transcription factors are used for Th1 and Th2 cytokine genes expression.9.We found a new soluble factor involved in the suppression of antibody production.