Molecular mechanism of immune regulation and immune tolerance

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This project was performed by three groups, 1) Molecular mechanisms of immune regulation ; 2) Molecular mechanisms of immune tolerance, and 3) Molecular mechanisms of immune diseases. These three groups cooperated with each other and the following results were obtained. Molecular mechanisms of immune regulation in immune response to natural antigens were elucidated by investigating the recognition of HLA/peptide complexes by TCRs and the resultant cytokine expression induced by interaction with the TCR.A wide range of subjects related to pathological causation were studied by analyzing the relationships between immune dysfunction and disease on a genetic level. Furthermore, several transgenic and gene knockout mouse such as the IL-2 receptor gamma chain mutant mice, CD3 deficient mouse, a TCR-Tg mouse, and the Lyn kinase and HS1 deficient mice were developed over the course of this project. Several domestic symposia, workshops and international symposia were also organized with the cooperation of individual researchers involved in this project.