课题基金 / 基金详情

Genetic alterations involved in initiation and progression of human cancer

Genetic alterations involved in initiation and progression of human cancer
基因改变参与人类癌症的发生和进展
批准号:
07272204
负责人:
HORII Akira
金额:
$38.21万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 --

项目摘要

项目成果

HORII Akira的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
1. Among regions of frequent chromosomal aberrations, loss of three chromosomal regions, 12q, 17p, and 18q, associated with poor prognosis in human pancreatic cancer. Ade noviral mediated delivery of the SMAD4 gene in pancreatic cancer cell lines with homozygous deletion of SMAD4 did not show any suppression of cell growth. We previously reported that loss of 18q is an early event in pancreatic carcinogenesis. There is a possibility that mutation of the SMAD4 gene is responsible for the initial step of pancreatic carcinogenesis as well as prognosis defining factor. However there is a possibility of unknown tumor suppressor gene on 18q that is distinct from SMAD4.2. We and others previously reported frequent somatic mutation of the PTEN gene in endometrial cancer. We attempted a trial of gene therapy by adenovirus mediated introduction of this gene in endometrial cancer cell lines with two-hit mutation of this gene. The trial was successful in vitro, and apoptosis was induced in tumor cells after introduction of normat copy of PTEN.However, the attempt was not successful in vivo. These results suggested that the PTEN gene is a good candidate for gene therapy in human endometrial cancer after appropriate improvement.3. In human lung cancer, frequent loss of 10q at the DMBT1 locus was found. Moreover, mutation as well as suppression of expression was found in this gene. There is a possibility that DMBT1 acts as the tumor suppressor gene in human lung carcinogenesis.4. In neuroblastoma, allelic loss was studied in 14q and identified a 500-kb region of common deletion on 14q32. A BAC contig harboring the deleted region was also constructed. On the other hand, a break point on 1p32 that occurred in a neuroblastoma patient with constitutional reciprocal translocation was also cloned. We are attempting to isolate the genes responsible for neuroblastoma.
期刊论文(168)
专著(0)
科研奖励(0)
会议论文
Kimura, M.: "HMB-45 and tuberin in hamartomas associated with tuberous sclerosis." Modern Pathology. 10. 952-959 (1997)
Kimura, M.:“与结节性硬化症相关的错构瘤中的 HMB-45 和马铃薯蛋白。”
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Saito, A., Furukawa, T., Fukushige, S., Koyama, S., Hoshi, M., Hayashi, Y., and Horii, A: "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1."J.Hum.Genet. (in press).
Saito, A.、Furukawa, T.、Fukushige, S.、Koyama, S.、Hoshi, M.、Hayashi, Y. 和 Horii, A:“p24/ING1-ALT1 和 p47/ING1-ALT2,不同的替代方案
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Amari, M.: "LOH analyses of premalignant and malignant lesion of the human breast : Frequent LOHs in 8p, 16q, and 17q in atypical ductal hyperplasia"Oncol. Rep.. 6. 1277-1280 (1999)
Amari, M.:“人类乳腺癌前和恶性病变的 LOH 分析:非典型导管增生中 8p、16q 和 17q 中频繁的 LOH”Oncol。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
101
    Development of invasion and/or metastasis of pancreatic and lung cancers by controlling S100A4
    • 批准号:
      23590452
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2011
    • 负责人:
      HORII Akira
    • 依托单位:
    Identification of a novel tumor suppressor gene on chromosome arm 18q in human pancreatic caner
    • 批准号:
      18390118
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.88万
    • 财政年份:
      2006
    • 负责人:
      HORII Akira
    • 依托单位:
    New avenue for molecular diagnosis of pancreatic and gynecological cancers
    • 批准号:
      17015003
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $27.78万
    • 财政年份:
      2005
    • 负责人:
      HORII Akira
    • 依托单位:
    Reseearch on Genetic Alterations in the Development and Progression of Human Pancreatic Cancer
    • 批准号:
      12470043
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.5万
    • 财政年份:
      2000
    • 负责人:
      HORII Akira
    • 依托单位:
    海外基金