Deposition of inhaled aerosols: a biological-fluid mechanical analysis of the deposition of particles in a respiratory model to assess the propagation of inhaled agents and the efficiency and toxicity of active substances in human airways using allicin as

吸入气溶胶的沉积：对呼吸模型中颗粒沉积的生物流体机械分析，以评估吸入剂的传播以及人体呼吸道中活性物质的效率和毒性，使用大蒜素作为

• 批准号: 468940454
• 负责人: Dr. Martin Gruhlke
• 金额: --
• 依托单位: Lehrstuhl für Strömungslehre und Aerodynamisches Institut (AIA)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/468940454?language=en
• 关键词: Deposition; inhaled; aerosols; biological; fluid

The severe respiratory disease COVID-19 is caused by the corona virus SARS-CoV-2. The primary transmission route is through aerosol inhalation, i.e., airborne droplet infection, either through direct contact with infected patients or indirectly via aerosols, e.g., in contaminated rooms. Also, life-threatening respiratory diseases that are caused by bacteria, e.g., pneumonia and tuberculosis, are transmitted via inhalation of infected droplets. To better understand the progression of these diseases from infection through symptom onset to hospitalization, it is a must to analyze the particle deposition of the virus- and bacteria-containing aerosols in the human airways in detail.An effective treatment of these respiratory diseases requires new approaches new classes of pharmaceutical active agents as well as new application strategies. Respiratory diseases provide the opportunity to apply the drugs via the inhalation of aerosols. New active substances, however, must be tested for their toxicity and efficiency in preclinical studies. In this context, the deposition of the aerosols of active agents in the respiratory tract is of particular importance.The scope of this study is to develop, evaluate and establish a fully three-dimensional, generic model of the human respiratory tract that allows to analyze the deposition of virus- and drug-containing aerosols in the human respiratory system under realistic in vitro conditions and to assess the toxicity and efficiency of drug-containing aerosols in a non-animal alternative test system using a combined approach of biology and experimental fluid mechanics.

严重的呼吸道疾病COVID-19是由冠状病毒SARS-CoV-2引起的。主要传播途径是通过雾化吸入，即，空气飞沫感染，无论是通过直接接触受感染的病人或间接通过气溶胶，例如，在受污染的房间里此外，由细菌引起的危及生命的呼吸道疾病，例如，肺炎和肺结核是通过吸入受感染的飞沫传播的。为了更好地了解这些疾病从感染到症状发作到住院治疗的过程，必须详细分析含病毒和细菌的气溶胶在人体气道中的颗粒沉积。有效治疗这些呼吸道疾病需要新的方法，新的药物活性剂以及新的应用策略。呼吸系统疾病提供了通过吸入气雾剂应用药物的机会。然而，新的活性物质必须在临床前研究中测试其毒性和有效性。在这种情况下，活性剂的气溶胶在呼吸道中的沉积是特别重要的。本研究的范围是开发、评估和建立一个完全三维的，人类呼吸道的通用模型，允许在真实的体外条件下分析含病毒和药物的气溶胶在人类呼吸系统中的沉积，并评估药物的毒性和有效性。使用生物学和实验流体力学相结合的方法，在非动物替代试验系统中对含有气溶胶的样品进行了测试。