Interactive effect of osmoregulatory and volume regulatory stimuli on thermoregulation.

渗透压调节和容量调节刺激对体温调节的相互作用。

• 批准号: 14570064
• 负责人: TAKAMATA Akira
• 金额: $ 2.24万
• 依托单位: Nara Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570064/
• 关键词: thermoregulation; body fluid regulation; plasma osmolality; thermogenesis; skin-vascular conductance; body core temperature threshold; baroreceptor unloading; osmoregulaotry center; 皮膚血管拡張反応; 能動的血管拡張システム; 血管収縮神経活動; ブレチリウム; 交感神経; 容量調節; 心肺圧受容器

To gain better insights into the interaction between fluid regulatory and thermoregulatory systems, we examined the effect of body fluid regulatory stimuli on thermoregulatory responses in human subjects.Upright posture reduced thermogenesis in response to body core cooling, compared with supine position. In contrast, upright posture enhanced peripheral vasoconstriction. Therefore, the thermoregulatory response to cold stress is influenced by volume regulatory system. The results also suggest that the mechanisms controlling peripheral vasoconstriction and thermogenesis during cold stress are appeared to be independent. We also examined the effect of plasma hyperosmolality on baroreceptor unloading-induced peripheral vasoconstriction. Plasma hyperosmolality augmented the reduction of forearm vascular conductance induced by lower body negative pressure during heat stress but not during normothermia. Therefore, there. apparently exists an interactive effect of plasma hyperosmolality and c … More entral hypovoloemia on the peripheral vascular response during heat stress, but not during normothermia. Our findings suggest that plasma hyperosmolality enhances baroreceptor-mediated reduction of thermal active peripheral vasodilation, but does not enhance the vasoconstrictor system.In a series of animal experiments, we examined the central mechanisms of the body fluid regulatory system. We quantified the permeability of capillaries in the subfornical organ of rat by a nuclear magnetic resonance method in combination with a venous injection of a relaxation reagent, Gd-DTPA^<2-> which could not pass through the blood-brain barrier (BBB). The proposed value may be 10-100 times larger than that of the blood-barrier in the cortex. We conclude that the capillaries in the SFO have one of the highest water permeability values among all of the capillaries in the brain, and this site may play an important role in osmoreception. In another animal experiment, we suggest that Mn^<2+> MRI is a useful technique for identifying in vivo the active brain region in the hypothalamus in response to various stimuli. Less

为了更好地了解体液调节系统和体温调节系统之间的相互作用，我们研究了体液调节刺激对人体体温调节反应的影响。与仰卧位相比，直立位减少了对身体核心冷却的产热反应。相反，直立姿势增强外周血管收缩。因此，对冷应激的体温调节反应受容积调节系统的影响。结果还表明，在冷应激过程中，控制外周血管收缩和产热的机制似乎是独立的。我们还研究了血浆高渗对压力感受器卸载诱导的外周血管收缩的影响。血浆高渗透压可增强热应激时下体负压引起的前臂血管传导性的降低，但在常温下无此作用。因此，在那里。血浆高渗浓度与C ...更多信息 中心性低血容量对热应激时外周血管反应的影响，但对常温时无影响。我们的研究结果表明，血浆高渗透压可增强压力感受器介导的热活性外周血管舒张的减少，但不会增强血管收缩系统。在一系列动物实验中，我们研究了体液调节系统的中枢机制。本文用核磁共振方法结合静脉注射不能通过血脑屏障（BBB）的舒张剂Gd-DTPA_（12），定量测定了大鼠穹窿下器毛细血管通透性<2->。建议的值可能比皮质中的血液屏障大10-100倍。我们的结论是，毛细血管在SFO中有一个最高的水渗透性值之间的所有毛细血管在大脑中，这个网站可能发挥重要作用，在电子邮件接收。在另一项动物实验中，我们认为Mn^&lt;2+&gt; MRI是一种有用的技术，可用于识别活体下丘脑中对各种刺激做出反应的活跃脑区。少

项目成果

Nakajima Y, Takamata A, Ito T, Sessler DI, Kitamura Y, Shimosato G, Taniguchi S, Matsuyama H, Tanaka Y, Mizobe T.: "Upright posture reduces thermogenesis and augments core hypothermia."Anesth Analg.. 94(6). 1646-1651 (2002)

Nakajima Y、Takamata A、Ito T、Sessler DI、Kitamura Y、Shimosato G、Taniguchi S、Matsuyama H、Tanaka Y、Mizobe T.：“直立姿势可减少生热作用并增强核心体温过低。”Anesth Analg.. 94(6)

Morita H, Ogino T, Seo Y, Fujiki N, Tanaka K, Takamata A, et al.: "Detection of hypothalamic activation by manganese ion contrasted T(1)-weighted magnetic resonance imaging in rats."Neurosci Lett.. 326. 101-104 (2002)

Morita H、Ogino T、Seo Y、Fujiki N、Tanaka K、Takamata A 等人：“通过锰离子对比 T(1) 加权磁共振成像检测大鼠下丘脑的激活。”Neurosci Lett.. 326。

Kasai T, Hirose M, Matsukawa T, Takamata A, Yaegashi K, Tanaka Y.: "Preoperative blood pressure and catecholamines related to hypothermia during general anesthesia."Acta Anaesthesiol Scand. 47(2). 208-212 (2003)

Kasai T、Hirose M、Matsukawa T、Takamata A、Yaegashi K、Tanaka Y.：“术前血压和儿茶酚胺与全身麻醉期间体温过低有关。”Acta Anaesthesiol Scand。

Seo Y, Takamata A, Ogino T, Morita H, Nakamura S, Murakami M.: "Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA^<2-> enhanced ^1H magnetic resonance imaging."J Physiol.. 545(Pt 1). 217-228 (2002)

Seo Y、Takamata A、Ogino T、Morita H、Nakamura S、Murakami M.：“通过 Gd-DTPA^<2-> 增强^1H 磁共振成像测定大鼠穹窿下器官毛细血管的水渗透性。”J Physiol

Morita H, Ogino T, Seo Y, Fujiki N, Tanaka K, Takamata A, Nakamura S, Murakami M: "Detection of hypothalamic activation by manganese ion contrasted T_1-weighted magnetic resonance imaging in rats"Neuroscience Letter. 326・2. 101-104 (2002)

Morita H、Ogino T、Seo Y、Fujiki N、Tanaka K、Takamata A、Nakamura S、Murakami M：“通过锰离子对比 T_1 加权磁共振成像检测大鼠下丘脑激活”神经科学快报 326・2。 -104 (2002)