An epidemiological study on the health effects of printing toner dust inhalation

吸入打印碳粉粉尘对健康影响的流行病学研究

• 批准号: 14570306
• 负责人: NAKADATE Toshio
• 金额: $ 2.24万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570306/
• 关键词: Printing toner dust; Lung interstitial fibrosis; spirometry; Chest radiography; Magnetopnermography; Biomarker; Epidemiology; Health risk; 印刷用トナー; じん肺; 肺機能; 呼吸器症状; 肺磁界; 疫学研究

Although recent case reports suggested possible respiratory effects of solid toner dust inhalation, there has been no epidemiological study examining this hypothesis. The objective of this research was to evaluate cross-sectionally the association between several biological indices of lung fibrosis and toner dust exposure condition in an occupational cohort handling solid toner dust in their daily work..A total of 1032 subjects were surveyed repeatedly twice (690 in the first year and 792 in the second). They were examined in terms of subjective respiratory symptoms, pulmonary function, several biomarker levels in serum and urine, and chest radiography. In addition to exposure history, current working conditions and personal exposure levels to toner dust were also examined. Those biological outcomes were cross-sectionally evaluated in association with exposure parameters.Although the subjects handling toner more than 20 years had a tendency to show higher prevalence of respiratory symptoms and minimal chest x-ray abnormality, there was no consistent relationship between toner dust exposure and biological findings. Current work environment of toner dust was considered to be adequately controlled below the permissible level recommended by the authorities.Thus we conclude that respiratory health deterioration related with toner dust exposure is less possible if powdered toner is handled carefully in current well-controlled work environment. However, epidemiological evidences on the biological effects of toner dust inhalation should be further accumulated, especially in a longitudinal study design.

虽然最近的病例报告表明吸入固体墨粉粉尘可能对呼吸系统产生影响，但还没有流行病学研究来检验这一假设。本研究的目的是在日常工作中接触固体墨粉粉尘的职业队列中，横断面评估肺纤维化的几个生物学指标与墨粉粉尘暴露条件之间的关联。共有1032名受试者接受了两次重复调查（第一年690人，第二年792人）。他们进行了主观呼吸系统症状，肺功能，血清和尿液中的几种生物标志物水平，胸部X线摄影检查。除了接触历史外，还检查了当前的工作条件和个人接触墨粉粉尘的水平。这些生物学结果进行了横断面评估与曝光parameters.Although主题处理碳粉超过20年有一个倾向，表现出较高的患病率的呼吸道症状和最小的胸部X线异常，碳粉粉尘暴露和生物学发现之间没有一致的关系。目前的工作环境中的碳粉粉尘被认为是充分控制低于当局建议的允许水平。因此，我们得出结论，如果在目前控制良好的工作环境中小心处理粉状碳粉，那么与碳粉粉尘接触相关的呼吸系统健康恶化的可能性较小。然而，墨粉粉尘吸入生物学效应的流行病学证据还有待进一步积累，特别是在纵向研究设计中。

项目成果

山野優子: "低濃度曝露とバイオマーカー"日本産業衛生学雑誌. 44. A123-A125 (2002)

Yuko Yamano：“低浓度暴露和生物标志物”日本工业卫生杂志 44. A123-A125 (2002)。

Nakadate t, yagami T, Zheng Y, Kotani M.: "Three phase magnetization method: An improved way of magnetopneumographic measurement."Proceedings of the 13th International Conference on Biomagnetism. 1069-1071 (2002)

Nakadate t、yagami T、Zheng Y、Kotani M.：“三相磁化法：一种改进的磁肺测量方法。”第 13 届国际生物磁学会议论文集。

T.Nakadate, T.Yagami, Y.Zheng, M.Kotani: "Three phase magnetization method : An improved way of magnetopneumographicmeasurement"Proceedings of the 13th International Conference on Biomagnetism. 1069-1071 (2002)

T.Nakadate、T.Yagami、Y.Zheng、M.Kotani：“三相磁化法：一种改进的磁呼吸测量方法”第 13 届国际生物磁学会议论文集。

Zheng Y, Guiyaol C, Kotani M, Uchikawa Y, Nakadate Y, Yagami T.: "Establishment of the Accurate Measurements of the Magnetic Field @Produced by Accumulated Particles in the Lungs."Proceedings of the 13th International Conference on Biomagnetism. 1134-1136

郑 Y、Guiyaol C、Kotani M、Uchikawa Y、Nakadate Y、Yagami T.：“建立由肺部累积颗粒产生的磁场的精确测量。”第 13 届国际生物磁学会议论文集。

Y.Zheng, C.Guiyao, M.Kotani, Y.Uchikawa, T.Nakadate, T.Yagami: "Establishment of the Accurate Measurements of the Magnetic Field Produced by Accumulated Particles in the Lungs"Proceedings of the 13th International Conference on Biomagnetism. 1134-1136 (20

Y.Zheng、C.Guiyao、M.Kotani、Y.Uchikawa、T.Nakadate、T.Yagami：“建立肺部累积颗粒产生的磁场的精确测量”第十三届国际生物磁学会议论文集