An epidemiologic study on the relationship between pulmonary function decline and serum cytokine level.

肺功能下降与血清细胞因子水平关系的流行病学研究

• 批准号: 08670458
• 负责人: NAKADATE Toshio
• 金额: $ 0.38万
• 依托单位: TOKYO WOMEN'S MEDICAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670458/
• 关键词: Obstructive lung Disease; Forced expiratory volume in on second; Cytokine; Longitudinal study; Prediction; Spirometry; Mineral fiber; Asbestos

The association between cross-sectional serum cytokine level and longitudinal pulmonary function decline was investigated in order to examine whether or not the serum cytokine level can predict an accelerated pulmonary function decline with aging. Subjects were the male workers who have been longitudinally followed-up since 1985 in terms of pulmonary function decline. In addition to routine spirometric indices such as forced expiratory volume in one second, time domain spirometric indices for lung time constant distribution were analyzed. Serum concentration of interleukin-4, interleukin-6, and interferon-gamma was measured utilizing the high-sensitivity chemiluminescence ELISA method devised by Tollerud and co-workers. Analysis was conducted on 328 sub-jects whose pulmonary function have been acceptably followed-up for at least 6 years.A large between-subject variability was recognized in all of the three types of cytokine. Their distribution was greatly skewed towards positive. That is especially marked in interferon-gamma. There was no evident relationship between serum cytokine level and allergic history of skin and respiratory system. No clear association was found either between serum cytokine level and chronic respiratory symptoms, smoking or other life style factors. Several longitudinal pulmonary function indices calculated as a regression coefficient, however, were significantly associated with the serum cytokine level. These findings do not necessary mean the usefulness of serum cytokine measurement in predicting pulmonary function decline, because of their large between-subject variability. Further work will be needed especially to study within-subject variability of serum cytokine level in a cohort setting of a large sample.

研究了横断面血清细胞因子水平与纵向肺功能下降之间的相关性，以检查血清细胞因子水平是否可以预测随着衰老而加速的肺功能下降。研究对象为自1985年以来进行肺功能下降纵向随访的男性工人。除常规肺功能测定指标（如1秒用力呼气量）外，还分析了肺时间常数分布的时域肺功能测定指标。使用Tollerud及其同事设计的高灵敏度化学发光ELISA方法测量白细胞介素-4、白细胞介素-6和干扰素-γ的血清浓度。对328例肺功能随访6年以上的亚健康者进行分析，发现3种细胞因子均存在较大的个体间变异性。它们的分布大大偏向正值。这在干扰素-γ中尤为明显。血清细胞因子水平与皮肤及呼吸系统过敏史无明显关系。血清细胞因子水平与慢性呼吸道症状、吸烟或其他生活方式因素之间无明显相关性。几个纵向肺功能指数计算的回归系数，但是，显着相关的血清细胞因子水平。这些发现并不一定意味着血清细胞因子测量在预测肺功能下降方面的有用性，因为它们具有较大的受试者间变异性。需要进一步的工作，特别是在一个大样本的队列设置中研究受试者内血清细胞因子水平的变异性。

项目成果

中館 俊夫: "縦断研究による成人男性の一秒量、努力性肺活量の加齢低下" 日本胸部疾患学会雑誌. 35・9. 954-959 (1997)

Toshio Nakadate：“基于纵向研究的成年男性每秒容量和用力肺活量的年龄相关下降”日本胸科疾病学会杂志 35・9（1997）。

Toshio Nakadate: "Pre-existing pulmonary fibrosis and subsequent acceleration of PEV1 decline." Excerpta Medica-International Congress Series. 1153(in printing). (1998)

Toshio Nakadate：“预先存在的肺纤维化和随后的 PEV1 下降加速。”

中館俊夫: "縦断観察による成人男性の一秒量、努力性肺活量の加齢低下" 日本胸部疾患学会雑誌. 35・9. 954-959 (1997)

Toshio Nakadate：“基于纵向观察的成年男性每秒容量和用力肺活量的年龄相关下降”日本胸科疾病学会杂志 35・9（1997）。

Tosio Nakadate: "Pre-existing Pulmonary Fibrosis and Subsoquent Acceleration of FEV1 decline" Excerpta Medica, International Congress Series. 1153 (in printing).

Tosio Nakadate：“预先存在的肺纤维化和 FEV1 下降的随后加速”医学摘录，国际大会系列。

Toshio Nakadate: "Pre-existing pulmonary fibrosis and subsequent acceleration of FEUl decline." Excerpta Medica,International congress series.1153(in printing). (1998)

Toshio Nakadate：“预先存在的肺纤维化和随后 FEU1 下降的加速。”