Serum hepatocyte growth factor concentration is related to hypertension-An epidemiological study-

血清肝细胞生长因子浓度与高血压相关-流行病学研究-

• 批准号: 14570368
• 负责人: ADACHI Hisashi
• 金额: $ 2.62万
• 依托单位: KURUME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570368/
• 关键词: Adipocyte; Cytokine; Epidemiology; Insulin resistance; Atherosclerosis; 肝細胞増殖因子; 内皮機能; 内皮機能障害; 住民検診; von willebrand factor; フィブリノーゲン; 高血圧

Hepatocyte growth factor (HGF) is one of adipo-cytokines. We evaluated whether serum levels of HGF are related to the components of the metabolic, syndrome (MS). A total of 1,474 subjects of a general population free of liver, kidney, and lung diseases received a health examination. We measured blood pressure (BP), waist circumference, body mass index (BMI), fasting plasma glucose (FPG), lipid profiles, serum insulin, and HGF concentrations. Uni-and multivariate analyses for determinant of HGF were performed. In a univariate analysis, all of the components (waist circumference, triglycerides, I-IDL-cholesterol, BP, and FPG) of the MS were significantly related to HGF levels. By the use of multiple stepwise regression analysis, HGF levels were significantly related to the components of the MS such as waist circumference (p<0.001), HDL-cholesterol (p<0.001,inversely), and systolic BP p<0.05). When HGF levels adjusted for age, sex and BMI were divided into quartiles, they linearly increased as waist circumference increased (p<0.001), and decreased as HDL-cholesterol increased (p<0.001). A linear significant trend. (p<0.001) was shown between HGF levels and aggregation of the components of the MS. Our results indicate that serum HGF levels are strongly associated with the components of the MS.

肝细胞生长因子（HGF）是一种脂肪细胞因子。我们评估了血清HGF水平是否与代谢综合征（MS）的组分相关。共有1，474名无肝脏、肾脏和肺部疾病的普通人群接受了健康检查。我们测量了血压（BP）、腰围、体重指数（BMI）、空腹血糖（FPG）、血脂、血清胰岛素和HGF浓度。对影响肝细胞生长因子的因素进行单因素和多因素分析。在单变量分析中，MS的所有组分（腰围、甘油三酯、I-IDL-胆固醇、BP和FPG）与HGF水平显著相关。多元逐步回归分析显示，肝细胞生长因子水平与代谢综合征各组分如腰围（p<0.001）、高密度脂蛋白胆固醇（p<0.001）、收缩压（p<0.05）呈显著负相关。当按年龄、性别和BMI调整HGF水平后，将其分为四分位数时，它们随腰围增加而线性增加（p<0.001），随HDL-胆固醇增加而降低（p<0.001）。线性显著趋势。结果显示，血清HGF水平与MS组分的聚集之间存在显著性差异（p<0.001）。我们的结果表明，血清HGF水平与MS组分密切相关。

项目成果

Hiratsuka A, Adachi H. et al.: "Obesity is related to increased levels of serum hepatocyte growth factor (HGF)"Circulation Journal. SuppleI 68. 14 (2004)

Hiratsuka A、Adachi H. 等人：“肥胖与血清肝细胞生长因子 (HGF) 水平升高有关”循环杂志。

Hiratsuka A, Adachi H et al.: "Obesity is related to increased levels of serum hepatocyte growth factor (HGF)"Circulation Journal Supple I. 68. 114 (2004)

Hiratsuka A、Adachi H 等人：“肥胖与血清肝细胞生长因子 (HGF) 水平升高有关”Circulation Journal Supple I. 68. 114 (2004)

Akiko Hiratsuka, Hisashi Adachi: "Serum hepatocyte growth factor, concentration is related to hypertension-An Epidemiological Study-"Cireulation. 106 II-733. 733 (2002)

Akiko Hiratsuka、Hisashi Adachi：“血清肝细胞生长因子、浓度与高血压相关-一项流行病学研究-”循环。

Akiko Hiratsuka, Hisashi Adachi: "Serum hepatocyte growth factor, concentration is related to hypertension-An Epidemiological Study-"Journal of Hyperleusion. 22,suppl.I. S208 (2004)

Akiko Hiratsuka、Hisashi Adachi：“血清肝细胞生长因子、浓度与高血压相关-一项流行病学研究-”Journal of Hyperleusion。

Hisashi Adachi, Yuji Hirai et al.: "Novel risk factors for cardiovascular disease : an epidemiological study in Tanushimaru Japan"Backhuys Publishers. 213-218 (2001)

Hisashi Adachi、Yuji Hirai 等：“心血管疾病的新危险因素：日本田主丸的流行病学研究”Backhuys 出版社。