Serum hepatocyte growth factor concentration is related to hypertension-An epidemiological study-

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Hepatocyte growth factor (HGF) is one of adipo-cytokines. We evaluated whether serum levels of HGF are related to the components of the metabolic, syndrome (MS). A total of 1,474 subjects of a general population free of liver, kidney, and lung diseases received a health examination. We measured blood pressure (BP), waist circumference, body mass index (BMI), fasting plasma glucose (FPG), lipid profiles, serum insulin, and HGF concentrations. Uni-and multivariate analyses for determinant of HGF were performed. In a univariate analysis, all of the components (waist circumference, triglycerides, I-IDL-cholesterol, BP, and FPG) of the MS were significantly related to HGF levels. By the use of multiple stepwise regression analysis, HGF levels were significantly related to the components of the MS such as waist circumference (p<0.001), HDL-cholesterol (p<0.001,inversely), and systolic BP p<0.05). When HGF levels adjusted for age, sex and BMI were divided into quartiles, they linearly increased as waist circumference increased (p<0.001), and decreased as HDL-cholesterol increased (p<0.001). A linear significant trend. (p<0.001) was shown between HGF levels and aggregation of the components of the MS. Our results indicate that serum HGF levels are strongly associated with the components of the MS.