Is cytokine from adipose tissue associated with metabolic syndrome?

在日本普通人群中检测了血浆单核细胞趋化蛋白-1（MCP-1）、肝细胞生长因子（HGF）、纤溶酶原激活物抑制剂-1（派-1）和肿瘤坏死因子-α（TNF-α）浓度与代谢综合征的关系。1999年，我们在日本福冈田沼丸的一个农业社区对1，492名年龄在40岁以上的受试者进行了健康检查。除了常规的危险因素外，我们还测量了HGF和派-1。2004-2007年，我们还在日本长崎宇久岛的一个渔业社区对842名受试者进行了健康检查。我们检测了脂肪细胞因子如MCP-1、派-1和TNF-α。校正年龄、性别和混杂因素后的多元线性回归分析显示，MCP-1和派-1与胰岛素抵抗显著相关，HGF和TNF-α与代谢综合征组分显著相关。HGF和TNF-α水平随代谢综合征患者数量的增加而升高（P<0.05）。总之，我们的结果表明，血清HGF和TNF-α与代谢综合征密切相关。比较脂肪细胞因子与代谢综合征在不同地区（农业和渔业地区）之间的关联强度是非常有趣的。在不久的将来，可能需要进行纵向流行病学调查，以澄清它们之间的地区差异。

The relationships between plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), plasminogen activator ihhibitor-1 (PAI-1) and TNF-α and the metabolic syndrome were examined in a Japanese general population. In 1999, we conducted a health examination in 1,492 subjects, aged 40 years or older in a farming community, Tanushimaru, Fukuoka, Japan. We measured HGF and PAI-1 in addition to conventional risk factors. We also performed a health examination in 842 subjects in a fishing community, Uku Island, Nagasaki, Japan in 2004-2007. We measured adipocytekine such as MCP-1, PAI-1, and TNF-α. With multiple linear regression analysis after adjustments for age, sex, and confounders, MCP-1 and PAI-1 were significantly related to insulin resistance, and also HGF and TNF-α were associated with the component of the metabolic syndrome. HGF and TNF-α levels were higher (p<0.05) in proportion to the accumulation of the number of the metabolic syndrome. In conclusion, our results indicate that serum HGF and TNF-α are strongly associated with the metabolic syndrome. It is very interesting that comparing the strength of associations between adipocytekine and the metabolic syndrome in different districts (farming and fishing areas). A longitudinal epidemiological survey may be needed to be clarified the area difference between them in the near future.