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Is cytokine from adipose tissue associated with metabolic syndrome?

脂肪组织中的细胞因子与代谢综合征有关吗？

基本信息

批准号：
18590621
负责人：
ADACHI Hisashi
金额：
$ 2.57万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590621/
关键词：
Health care Disease prevention Cytokine Metabolic syndrome Epidemiology

项目摘要

The relationships between plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), plasminogen activator ihhibitor-1 (PAI-1) and TNF-α and the metabolic syndrome were examined in a Japanese general population. In 1999, we conducted a health examination in 1,492 subjects, aged 40 years or older in a farming community, Tanushimaru, Fukuoka, Japan. We measured HGF and PAI-1 in addition to conventional risk factors. We also performed a health examination in 842 subjects in a fishing community, Uku Island, Nagasaki, Japan in 2004-2007. We measured adipocytekine such as MCP-1, PAI-1, and TNF-α. With multiple linear regression analysis after adjustments for age, sex, and confounders, MCP-1 and PAI-1 were significantly related to insulin resistance, and also HGF and TNF-α were associated with the component of the metabolic syndrome. HGF and TNF-α levels were higher (p<0.05) in proportion to the accumulation of the number of the metabolic syndrome. In conclusion, our results indicate that serum HGF and TNF-α are strongly associated with the metabolic syndrome. It is very interesting that comparing the strength of associations between adipocytekine and the metabolic syndrome in different districts (farming and fishing areas). A longitudinal epidemiological survey may be needed to be clarified the area difference between them in the near future.

对日本普通人群血浆单核细胞趋化蛋白-1、肝细胞生长因子、纤溶酶原激活物抑制物-1和肿瘤坏死因子-α水平与代谢综合征的关系进行了研究。1999年，我们在日本福冈谷岛丸的一个农业社区对1,492名年龄在40岁或以上的受试者进行了健康检查。除了常规的危险因素外，我们还检测了HGF和PAI-1。2004-2007年间，我们还对日本长崎Uku岛的一个渔业社区的842名受试者进行了健康检查。检测脂肪细胞因子单核细胞趋化蛋白-1、纤溶酶原激活物-1和肿瘤坏死因子-α。经多元线性回归分析，调整年龄、性别和混杂因素后，单核细胞趋化蛋白-1和纤溶酶原激活物-1与胰岛素抵抗显著相关，肝细胞生长因子和肿瘤坏死因子-α也与代谢综合征的构成因素相关。肝细胞生长因子和肿瘤坏死因子-α水平与代谢综合征的积累量成正比(p&lt；0.05)。综上所述，我们的结果表明血清肝细胞生长因子和肿瘤坏死因子-α与代谢综合征密切相关。比较不同地区(农业和渔区)脂肪细胞因子和代谢综合征之间的关联强度是非常有趣的。在不久的将来，可能需要进行一次纵向流行病学调查，以澄清它们之间的地区差异。