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MECHANISM OF REGULATING MOBILIZATION AND MIGRATION OF ANTIGEN PRESENTING CELLS DURING INFLAMMATION

炎症过程中抗原呈递细胞动员和迁移的调节机制

基本信息

批准号：
14570507
负责人：
NAGATA Hiroshi
金额：
$ 2.3万
依托单位：
Keio University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570507/
关键词：
macrophage dendritic cell colitis lymphatic vessel in mesentery mesenteric lymph node chemokine リンパ球ホーミング

项目摘要

Regulation of lymphocyte migration in the intestine under physiological and pathological conditionTECK/CCL25 plays an important role in the adherence of mucosal lymphocytes to the small intestine but not the colon under uniflamed as well as inflamed conditions. CD4T lymphocytes significantly accumulated in villus as well as in Peyer' s patches via a MAdCAM-1-dependent process in rats with a chronic allergy to ovalbumin.Migration kinetics of dendritic cells via intestinal lymphThe isolated dendritic cells accumulated in mesenteric lymph nodes in a time-dependent manner with maximal accumulation at 48 h. Inhibition of ICAM-1 or CD11b/c did not affect DC migration. The migratory ability of dendritic cells correlates well with their degree of maturation, and different chemokine/chemokine receptor usage may be the main regulator of dendritic cell migration kinetics through intestinal lymph.Response of macrophage in mesenteric lymph nodeParasinus macrophages play a role in the transient anti-metastatic capability of the node, and cytokines secreted by these cells increased at the early stages of metastasis. Deterioration of cytokine induction may be responsible for subsequent cancer proliferation. Macrophage migration inhibitory factor expressed in the cancer cells may modulate cytokine responses and migration of the macrophages.

生理和病理条件下肠内淋巴细胞迁移的调控teck /CCL25在粘膜淋巴细胞粘附于小肠而非结肠的过程中发挥重要作用。在对卵清蛋白慢性过敏的大鼠中，CD4T淋巴细胞通过madcam -1依赖性过程在绒毛和Peyer' s补丁中显著积累。分离的树突状细胞在肠系膜淋巴结中以时间依赖性的方式积聚，在48小时达到最大积聚。抑制ICAM-1或CD11b/c不影响DC的迁移。树突状细胞的迁移能力与其成熟程度密切相关，不同的趋化因子/趋化因子受体的使用可能是树突状细胞通过肠道淋巴迁移动力学的主要调节因子。巨噬细胞在肠系膜淋巴结中的应答：巨噬细胞在淋巴结的短暂抗转移能力中发挥作用，在转移早期，巨噬细胞分泌的细胞因子增加。细胞因子诱导的恶化可能导致随后的癌症增殖。巨噬细胞迁移抑制因子在癌细胞中的表达可能调节细胞因子反应和巨噬细胞的迁移。