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Analysis of lung carcinogenesis by hnRNP B1, a RNA binding protein, using SPC-hnRNP B1 transgenic mouse models

Analysis of lung carcinogenesis by hnRNP B1, a RNA binding protein, using SPC-hnRNP B1 transgenic mouse models
使用 SPC-hnRNP B1 转基因小鼠模型分析 RNA 结合蛋白 hnRNP B1 的肺癌发生
批准号：
14570555
负责人：
SUEOKA Eizaburo
金额：
$2.24万
依托单位：
Saga University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
项目状态：
已结题
起止时间：
2002 至 2003
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570555/
关键词：
Lung CancerRNA biniding proteinhnRNP B1transgenic mousesurfactant Protein C肺癌

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中文摘要
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英文摘要
We identified that hnRNP B1, a splicing variant of hnRNP A2, was overexpressed in nuclei of human lung cancer cells, from the early stage to the advanced : Moreover, hnRNP B 1 was overexpressed in squamous cell carcinoma in various organs, such as oral cavity and esophagus, in addition to lung. To clarify the role of hnRNP B1 for lung carcinogenesis, we constructed the chimeric genes fused with surfactant protein C promoter and hnRNP B1 cDNA. We obtained several transgenic clones of SPC-hnRNP BI, hnRNP A2 and GFP after introduction into ES cell neclei. Heterogenic transgenic mice were back-crossed to parental wild mice and we obtained F3 generations and homogygous mouse clones. High expression levels of hnRNP B1 protein were confirmed in the lungs of homogygous mice by immunohistocherriistry. Recent our study found hnRNP B1 interacted with a DNA repair protein complex and regulated its activity. To determine the precise role of hnRNP B1 in lung carcinogenesis associated with alteration of DNA repair activity, sequential analysis of pathological and cytogenetical analyses were under investigation.
期刊论文(24)
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会议论文
Iwanaga K, Sueoka N, Akemi S, Sakuragi T: "Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer"Cancer Letters. 202. 71-79 (2003)
Iwanaga K、Sueoka N、Akemi S、Sakuragi T：“tob（一种新型肿瘤抑制基因产物）的表达或磷酸化状态的改变是肺癌的早期事件”Cancer Letters。
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通讯作者：
Tominaga M, Sueoka N, Irie K, Iwanaga K, Tokunaga O, Hayashi S, Nakachi K, Sueoka E.: "Detection and discrimination of preneoplastic and early stages of lung adenocarcinoma using hnRNP B1 combined with the cell cycle-related markers p16, cyclin Dl, and Ki
Tominaga M、Sueoka N、Irie K、Iwanaga K、Tokunaga O、Hayashi S、Nakachi K、Sueoka E.：“使用 hnRNP B1 结合细胞周期相关标记物 p16 检测和区分肺腺癌的癌前和早期阶段，
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通讯作者：
Iwanaga K: "Alteration of expression or phosphorylation status of tob, a novel tumor suppress or gene product, is an early event in lung cancer."Cancer Letter. 202. 71-79 (2003)
Iwanaga K：“tob 的表达或磷酸化状态的改变是一种新型肿瘤抑制或基因产物，是肺癌的早期事件。”《癌症信》。
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Fujimoto N, Sueoka N, Sueoka E, Okabe S, et al.: "Lung cacner prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1."Int.J.Oncol.. 20. 1233-1239 (2002)
Fujimoto N、Sueoka N、Sueoka E、Okabe S 等人：“通过异质核核糖核蛋白 B1 进行监测，用 (-)-表没食子儿茶素没食子酸酯预防肺癌。”Int.J.Oncol.. 20. 1233-1239 (2002)
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共 12 条
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      Saga University