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HIGHER BRAIN FUNCTION AND AUTONOMIC NERVOUS SYSTEM : URINARY-EVOKED FUNCTIONAL BRAIN MAPPING USING 3D-SSP

高级脑功能和自主神经系统：使用 3D-SSP 进行尿诱发功能性脑图绘制

基本信息

批准号：
14570579
负责人：
SAKAKIBARA Ryuji
金额：
$ 1.79万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570579/
关键词：
multiple system atrophy autonomic dysfunction urinary dysfunction SPECT functional brain imaging higher brain function 自律神経排尿機能 3D-SSP

项目摘要

SPECT brain imaging with special reference of bladder function was performed in 8 multiple system atrophy (MSA) patients (2 men, 6 women ; mean age, 61 years) and age-matched 5 normal control subjects (3 men, 2 women ; 62 years). In both groups imagings were obtained in 3 conditions ; empty bladder, storage, and micturition. 555 MBq of [^<99m>Tc]-labeled ECD was intravenously injected, which was immediately trapped and stabilized within the brain. Using NEUROSTAT software, which could also cancel morphologic differences between MSA and canonical brain, statistical difference between normalized mean tracer counts of both groups in each phase was calculated and visualized. In the storage phase, there was a significant decrease in tracer activity in bilateral cerebellar vermis, particularly of the right side in the MSA group (p<0.05), which is also known to be involved in the neural control of micturition. In the micturition phase, the area of decrease in tracer activity in the cerebellar vermis became wider in the MSA group. In the resting state, no statistically significance was seen between both groups. In conclusion, it is suggested that the decrease in tracer activity in the cerebellar vermis during urinary storage and micturition is contributing to the micturitional disturbance in this disorder.

对8例多系统萎缩（MSA）患者（男2例，女6例;平均年龄61岁）和5例年龄匹配的正常对照者（男3例，女2例; 62岁）进行了以膀胱功能为参考的SPECT脑显像。在两组中，在3种条件下获得成像：膀胱排空、储存和排尿。静脉注射555 MBq的[13 <99m>Tc]-标记的ECD，其立即被捕获并稳定在脑内。使用NEUROSTAT软件，也可以消除MSA和典型脑之间的形态学差异，计算并可视化两组在每个阶段的标准化平均示踪剂计数之间的统计学差异。在储存期，双侧小脑蚓部的示踪剂活性显著降低，特别是MSA组的右侧（p<0.05），这也是已知的参与排尿的神经控制。在排尿期，MSA组小脑蚓部示踪剂活性降低的区域变宽。在静息状态下，两组之间未观察到统计学显著性。总之，这表明，在尿储存和排尿过程中小脑蚓部示踪剂活性的减少是有助于排尿障碍，在这种疾病。