Bladder dysfunction in Parkinson's disease-analysis of micturition circuit in the basal ganglia using in vivo single unit microneurogram

帕金森病的膀胱功能障碍-使用体内单单位显微神经图分析基底节的排尿回路

• 批准号: 17591662
• 负责人: SAKAKIBARA Ryuji
• 金额: $ 2.57万
• 依托单位: Toho University (2007-2008)Chiba University (2005-2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591662/
• 关键词: パーキンソン病; 排尿障害; 大脳基底核; 単一神経活動電位; 自律神経

パーキンソン病の自律神経障害が近年QOL(生活の質)の観点から注目されている。このうち排尿障害(とくに頻尿・尿失禁)は約70%と高頻度にみられ、患者のQOLを損なうことから、治療上の重要なターゲットと考えられる。近年の研究によれば、排尿機能は、単純な脊髄反射ではなく、複雑な中枢神経支配を受けるとされている。すなわち、パーキンソン病における排尿障害の解明のためには、排尿に関連した中枢神経系の研究が重要と考えられる。2005-2008年度我々は、オス猫15頭を用いて、ケタミン麻酔下に挿管・呼吸器を装着、CO2モニター・動静脈カテーテル・膀胱カテーテル・外括約筋筋電図電極を装着し、自発性排尿反射を誘発。定位脳固定装置(Narishige)上でtungsten電極を線条体(尾状核、被殻)に刺入。同部位で単一神経活動電位記録・微小電気刺激を行った。微小電気刺激の結果、排尿抑制部位が尾状核腹側部に見出され、同部位に、排尿反射に応じて発火する単一ニューロン活動が認められた。すなわち、線条体は排尿の高次制御に積極的にかかわっている可能性があると考えられた。以上を国際雑誌に発表した。Yamamoto T, Sakakibara R, Nakazawa K, Uchiyama T, Shimizu E, Hattori T. Effects ofelectrical stimulation of the striatum on bladder activity in cats. Neurourol Urodynam 2009(in press)

In recent years, QOL(Quality of Life) has become the focus of attention. The frequency of urination and incontinence is about 70%. The frequency of urination and incontinence is about 70%. The patient's QOL is damaged. The treatment is important. In recent years, research has been conducted on urinary function, pure spinal reflex, and complex central nervous system control. It is important to study the relationship between urination and central nervous system. 2005-2008 15 heads of urine were used in the year, and the urine reflex was induced by the installation of CO2, arteriovenous, bladder, external tendon and electric electrode. Tungsten electrode strips (caudate nucleus, capsule) are inserted into the positioning fixture (Narishige). The same part of the brain activity potential recording, small electrical stimulation The results of microelectrical stimulation, urination inhibition site and caudate nucleus ventral part of the body, the same site, urination reflex, the first time the activity is recognized. The possibility of high order control of urination by linear and linear body is examined. The above international aspirations are expressed. Yamamoto T, Sakakibara R, Nakazawa K, Uchiyama T, Shimizu E, Hattori T. Effects ofelectrical stimulation of the striatum on bladder activity in cats. Neurourol Urodynam 2009(in press)

项目成果

Calcium polycarbophil improves constipation in primary autonomic failure and multiple system atrophy subjects

聚卡波非钙可改善原发性自主神经衰竭和多系统萎缩受试者的便秘

• 发表时间: 2007
• 期刊: Mov Disord 22:11
• 作者: Sakakibara R;Yamaguchi T;Uchiyama T;Yamamoto T;Ito T;Liu Z;Odaka T;Yamaguchi C;Hattori T
• 通讯作者: Hattori T

Urinary retention due to an isolated sacral root injury caused by sacral fracture

骶骨骨折引起孤立性骶根损伤导致尿潴留

• 发表时间: 2007
• 期刊: Spinal Cord 45:12
• 作者: Sakakibara R;Uchiyama T;Yamaguchi C;Yamamoto T;Ito T;Liu Z;Awa Y;Yamazaki M;Hattori T
• 通讯作者: Hattori T

Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy

艾灸是一种替代疗法，可改善多系统萎缩中血浆精氨酸加压素和尿量紊乱的昼夜节律

• 发表时间: 2007
• 期刊: Intern Med 46:13
• 作者: Sakakibara R;Murakami E;Katagiri A;Hayakawa S;Uchiyama T;Yamamoto T;Hattori T
• 通讯作者: Hattori T

Calcium polycarbophil improves constipation in primary autonomic failure and multiple system atrophy subjects.

聚卡波非钙可改善原发性自主神经衰竭和多系统萎缩受试者的便秘。

• 发表时间: 2007
• 期刊: Mov Disord. 22
• 作者: Sakakibara R;Yamaguchi T;et. al.
• 通讯作者: et. al.

Chronic intestinal pseudo-obstruction as the initial feature of pure autonomic failure J Neurol

慢性假性肠梗阻是纯粹自主神经衰竭的最初特征 J Neurol

• 发表时间: 2006
• 期刊: Neurosurg Psychiatry 77:6
• 作者: Yamanaka Y;Sakakibara R;Asahina M;Uchiyama T;Liu Z;Yamamoto T;Ito S;Suenaga T;Odata T;Yamaguchi T;Uehara K;Hattori T
• 通讯作者: Hattori T