Prospective and retrospective studies of mild cognitive impairment : Alzheimer disease and senile tauopathy

轻度认知障碍的前瞻性和回顾性研究：阿尔茨海默病和老年性tau蛋白病

• 批准号: 14570626
• 负责人: MURAYAMA Shigeo
• 金额: $ 2.24万
• 依托单位: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570626/
• 关键词: mild cognitive impairment; Alzheimer disease; Parkinson disease; brain bank; aging of the brain; neuropathology; positron emission tomography; biomarker of cerebrospinal fluid; タウオパチー; 嗜銀顆粒性痴呆; 神経原線維変化優位型痴呆; アミロイドβ蛋白; タウ; アポE蛋白; MCI; タウパチー

Mild cognitive impairment (MCI) is defined as the intermediate state between normal cognition and dementia and highlighted as the main target for preventive scheme against cognitive decline in the elderly.We screened clinical records of 1,120 serial autopsy cases from Tokyo Metropolitan Brain Bank for Aging Research in these five years. The cases equivalent to MCI were retrospectively selected by two professional neurologists independently, on the following criteria: 1.the description of memory impairment incurring problems for medical care,2.no definite description of dementia, and 3.Clinical Dementia Rating 0.5.One hundred and seventy one cases were pulled out as MCI equivalents. The background pathology of these cases consisted of 25 cases mainly presenting with Alzheimer disease (AD)-type pathology,23 cases of senile tauopathy, comprising dementia with grain or neuforibrillary tangle-predominant form of dementia-type changes and others.With this result, we have established the crit … More ical path for MCI. The initial screening consists of neurological examination, Mini-Mental State Examination and CTscan. The secondary screening includes volumetric MRI, statistical SPECT, the Rivermead Behavioral Memory Test (RBMT) and electroencephalography (EEG). Those patients who fulfill the criteria of MCI are recruited to the prospective study with informed consent. The advanced examination includes biological marker of cerebrospinal fluid (tau, phosphorylated tau and Abeta), apoE phenotyping, WAIS-R, WMS-R and PET scans. MCI cases with possible early AD or senile tauopathy are recruited to medical control by acetylcholine esterase inhibitor.We have run this critical path this year. Tentative summaries are as follows: 1.MCI includes many cases in addition to AD. 2.Appropriate medical intervention could prevent and, in some cases, reverse the progression of cognitive decline. 3.Early intervention is quite useful for the preservation of the quality of life.Further accumulation of the cases are now on going. Less

轻度认知障碍（Mild cognitive impairment， MCI）被定义为介于正常认知和痴呆之间的中间状态，是老年人认知能力下降预防方案的主要目标。我们筛选了近五年来东京都衰老研究脑库的1120例连续尸检病例的临床记录。相当于MCI的病例由两名专业神经学家独立地回顾性选择，标准如下：1。2.医疗护理中记忆障碍问题的描述。没有明确的痴呆描述；临床痴呆评分0.5。171例病例作为MCI等效病例被剔除。这些病例的背景病理包括25例主要表现为阿尔茨海默病（AD）型病理，23例为老年性痴呆，包括以颗粒状或神经小纤维缠结为主的痴呆型改变等。基于这一结果，我们为MCI建立了更为关键的路径。初步筛查包括神经系统检查、简易精神状态检查和ct扫描。二次筛查包括容积核磁共振、统计SPECT、Rivermead行为记忆测试（RBMT）和脑电图（EEG）。那些符合轻度认知损伤标准的患者在知情同意的情况下被招募到前瞻性研究中。高级检查包括脑脊液生物标志物（tau，磷酸化tau和β）， apoE表型，WAIS-R， WMS-R和PET扫描。可能有早期AD或老年性牛头病的MCI病例采用乙酰胆碱酯酶抑制剂进行医学控制。我们今年已经走了这条关键的道路。初步总结如下：MCI除AD外还包括许多病例。2.适当的医疗干预可以预防并在某些情况下逆转认知能力下降的进程。3.早期干预对于维持生活质量是非常有用的。目前正在进一步积累病例。少

项目成果

Saito Y, Nakahara K, Yamanouchi H, Murayama S: "Severe Involvement of ambient gyros in dementia with grains."Journal of Neuropathology and Experimental Neurology. 61. 789-796 (2002)

Saito Y、Nakahara K、Yamanouchi H、Murayama S：“环境陀螺仪严重影响谷物痴呆。”神经病理学和实验神经病学杂志。

Takeda, Y, Murayama, S. et al.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/ F3 subgroup."J Neurobiol. 56. 252-265 (2003)

Takeda, Y, Murayama, S. 等人：“缺乏 contactin/F3 亚组的神经识别分子 NB-3 的小鼠运动协调受损。”J Neurobiol。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Murayama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity"Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Murayama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积”《神经病学年鉴》。

Saito Y, Geyer A, Sasaki R, Kuzuhara S, Nanba E, Miyasaka T, Suzuki K, Murayama S: "Early onset, rapidly progressive familial tauopathy with R406W mutation"Neurology. 58. 811-813 (2002)

Saito Y、Geyer A、Sasaki R、Kuzuhara S、Nanba E、Miyasaka T、Suzuki K、Murayama S：“具有 R406W 突变的早发型、快速进展家族性 tau 病”神经病学。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Muravama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity."Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Muravama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积。”《神经病学年鉴》。