Prospective and retrospective studies of mild cognitive impairment : Alzheimer disease and senile tauopathy

轻度认知障碍的前瞻性和回顾性研究：阿尔茨海默病和老年性tau蛋白病

• 批准号: 14570626
• 负责人: MURAYAMA Shigeo
• 金额: $ 2.24万
• 依托单位: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570626/
• 关键词: mild cognitive impairment; Alzheimer disease; Parkinson disease; brain bank; aging of the brain; neuropathology; positron emission tomography; biomarker of cerebrospinal fluid; タウオパチー; 嗜銀顆粒性痴呆; 神経原線維変化優位型痴呆; アミロイドβ蛋白; タウ; アポE蛋白; MCI; タウパチー

Mild cognitive impairment (MCI) is defined as the intermediate state between normal cognition and dementia and highlighted as the main target for preventive scheme against cognitive decline in the elderly.We screened clinical records of 1,120 serial autopsy cases from Tokyo Metropolitan Brain Bank for Aging Research in these five years. The cases equivalent to MCI were retrospectively selected by two professional neurologists independently, on the following criteria: 1.the description of memory impairment incurring problems for medical care,2.no definite description of dementia, and 3.Clinical Dementia Rating 0.5.One hundred and seventy one cases were pulled out as MCI equivalents. The background pathology of these cases consisted of 25 cases mainly presenting with Alzheimer disease (AD)-type pathology,23 cases of senile tauopathy, comprising dementia with grain or neuforibrillary tangle-predominant form of dementia-type changes and others.With this result, we have established the crit … More ical path for MCI. The initial screening consists of neurological examination, Mini-Mental State Examination and CTscan. The secondary screening includes volumetric MRI, statistical SPECT, the Rivermead Behavioral Memory Test (RBMT) and electroencephalography (EEG). Those patients who fulfill the criteria of MCI are recruited to the prospective study with informed consent. The advanced examination includes biological marker of cerebrospinal fluid (tau, phosphorylated tau and Abeta), apoE phenotyping, WAIS-R, WMS-R and PET scans. MCI cases with possible early AD or senile tauopathy are recruited to medical control by acetylcholine esterase inhibitor.We have run this critical path this year. Tentative summaries are as follows: 1.MCI includes many cases in addition to AD. 2.Appropriate medical intervention could prevent and, in some cases, reverse the progression of cognitive decline. 3.Early intervention is quite useful for the preservation of the quality of life.Further accumulation of the cases are now on going. Less

轻度认知障碍（MCI）被定义为正常认知和痴呆症之间的中间状态，并突出显示为预防性方案的主要目标，以防止老式的认知能力下降。我们在这五年中筛选了来自东京大都市大脑库的1,120例连续尸检病例的临床记录。根据以下标准，两位专业神经科医生独立选择了相当于MCI的病例：1。记忆力障碍的描述会导致医疗问题的问题，2。未定义的痴呆症的描述，3。在0.5.5.5.55的痴呆症评级为0.5.一百七十一例，将MCI MCI等于MCI等等。这些病例的背景病理学由25例主要出现阿尔茨海默氏病（AD） - 型病理学，23例老年陶氏病病例，以谷物或新纤维纤维纤维纤维缠结的痴呆形式的痴呆形式的痴呆型变化等。最初的筛查由神经检查，小精神状态检查和CTSCAN组成。次要筛选包括体积MRI，统计SPECT，Rivermead行为记忆测试（RBMT）和脑电图（EEG）。那些满足MCI标准的患者通过知情同意招募前瞻性研究。高级检查包括脑脊液（TAU，磷酸化的Tau和Abeta），ApoE表型，WAIS-R，WMS-R和PET扫描的生物学标记。乙酰胆碱酯酶抑制剂将可能的早期AD或老年大疾病的MCI病例招募到医疗控制。暂定摘要如下：1。MCI除了AD外还包括许多案例。 2.适当的医疗干预可以预防，在某些情况下，扭转了认知能力下降的进展。 3。早期干预对于保存生活质量非常有用。案件的积累现在正在进行中。较少的

项目成果

Saito Y, Nakahara K, Yamanouchi H, Murayama S: "Severe Involvement of ambient gyros in dementia with grains."Journal of Neuropathology and Experimental Neurology. 61. 789-796 (2002)

Saito Y、Nakahara K、Yamanouchi H、Murayama S：“环境陀螺仪严重影响谷物痴呆。”神经病理学和实验神经病学杂志。

Takeda, Y, Murayama, S. et al.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/ F3 subgroup."J Neurobiol. 56. 252-265 (2003)

Takeda, Y, Murayama, S. 等人：“缺乏 contactin/F3 亚组的神经识别分子 NB-3 的小鼠运动协调受损。”J Neurobiol。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Murayama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity"Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Murayama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积”《神经病学年鉴》。

Mawrin C, Lins H, Koenig B, Heinrichs T, Murayama S et al.: "Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitis"Neurology. 58. 1568-1571 (2002)

Mawrin C、Lins H、Koenig B、Heinrichs T、Murayama S 等人：“成人发病的亚急性硬化性全脑炎的时空疾病进展”神经病学。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Muravama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity."Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Muravama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积。”《神经病学年鉴》。