Prospective and retrospective studies of mild cognitive impairment : Alzheimer disease and senile tauopathy

轻度认知障碍的前瞻性和回顾性研究：阿尔茨海默病和老年性tau蛋白病

• 批准号: 14570626
• 负责人: MURAYAMA Shigeo
• 金额: $ 2.24万
• 依托单位: Tokyo Metropolitan Foundation for Research on Aging and Promotion of Human Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570626/
• 关键词: mild cognitive impairment; Alzheimer disease; Parkinson disease; brain bank; aging of the brain; neuropathology; positron emission tomography; biomarker of cerebrospinal fluid; タウオパチー; 嗜銀顆粒性痴呆; 神経原線維変化優位型痴呆; アミロイドβ蛋白; タウ; アポE蛋白; MCI; タウパチー

Mild cognitive impairment (MCI) is defined as the intermediate state between normal cognition and dementia and highlighted as the main target for preventive scheme against cognitive decline in the elderly.We screened clinical records of 1,120 serial autopsy cases from Tokyo Metropolitan Brain Bank for Aging Research in these five years. The cases equivalent to MCI were retrospectively selected by two professional neurologists independently, on the following criteria: 1.the description of memory impairment incurring problems for medical care,2.no definite description of dementia, and 3.Clinical Dementia Rating 0.5.One hundred and seventy one cases were pulled out as MCI equivalents. The background pathology of these cases consisted of 25 cases mainly presenting with Alzheimer disease (AD)-type pathology,23 cases of senile tauopathy, comprising dementia with grain or neuforibrillary tangle-predominant form of dementia-type changes and others.With this result, we have established the crit … More ical path for MCI. The initial screening consists of neurological examination, Mini-Mental State Examination and CTscan. The secondary screening includes volumetric MRI, statistical SPECT, the Rivermead Behavioral Memory Test (RBMT) and electroencephalography (EEG). Those patients who fulfill the criteria of MCI are recruited to the prospective study with informed consent. The advanced examination includes biological marker of cerebrospinal fluid (tau, phosphorylated tau and Abeta), apoE phenotyping, WAIS-R, WMS-R and PET scans. MCI cases with possible early AD or senile tauopathy are recruited to medical control by acetylcholine esterase inhibitor.We have run this critical path this year. Tentative summaries are as follows: 1.MCI includes many cases in addition to AD. 2.Appropriate medical intervention could prevent and, in some cases, reverse the progression of cognitive decline. 3.Early intervention is quite useful for the preservation of the quality of life.Further accumulation of the cases are now on going. Less

轻度认知功能障碍（MCI）是介于正常认知和痴呆之间的中间状态，是老年人认知功能减退预防的主要目标。本研究筛选了东京都老龄化研究脑库近5年来1,120例连续尸检病例的临床记录。由两名神经科医师根据以下标准独立回顾性选择符合MCI的病例：1.描述记忆障碍导致医疗护理问题，2.没有明确的痴呆描述，3.临床痴呆评分0.5。这些病例的背景病理包括25例主要表现为阿尔茨海默病（AD）型病理的病例，23例老年性tau蛋白病，包括痴呆伴颗粒或神经纤维缠结为主形式的痴呆型改变和其他。 ...更多信息 MCI的路径。初步筛查包括神经系统检查、简易精神状态检查和CT扫描。二次筛查包括容积MRI、统计SPECT、Rivermead行为记忆测试（RBMT）和脑电图（EEG）。符合MCI标准的患者在知情同意的情况下被招募到前瞻性研究中。高级检查包括脑脊液生物标志物（tau，磷酸化tau和Abeta），apoE表型，WAIS-R，WMS-R和PET扫描。MCI患者可能有早期AD或老年性tau蛋白病，我们招募他们通过乙酰胆碱酯酶抑制剂进行药物控制。初步总结如下：1. MCI包括除AD外的许多病例。2.适当的医疗干预可以预防，在某些情况下，逆转认知能力下降的进展。3.及早介入对维持生活质素十分有用，而有关个案现正不断累积。少

项目成果

Saito Y, Nakahara K, Yamanouchi H, Murayama S: "Severe Involvement of ambient gyros in dementia with grains."Journal of Neuropathology and Experimental Neurology. 61. 789-796 (2002)

Saito Y、Nakahara K、Yamanouchi H、Murayama S：“环境陀螺仪严重影响谷物痴呆。”神经病理学和实验神经病学杂志。

Takeda, Y, Murayama, S. et al.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/ F3 subgroup."J Neurobiol. 56. 252-265 (2003)

Takeda, Y, Murayama, S. 等人：“缺乏 contactin/F3 亚组的神经识别分子 NB-3 的小鼠运动协调受损。”J Neurobiol。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Murayama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity"Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Murayama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积”《神经病学年鉴》。

Saito Y, Geyer A, Sasaki R, Kuzuhara S, Nanba E, Miyasaka T, Suzuki K, Murayama S: "Early onset, rapidly progressive familial tauopathy with R406W mutation"Neurology. 58. 811-813 (2002)

Saito Y、Geyer A、Sasaki R、Kuzuhara S、Nanba E、Miyasaka T、Suzuki K、Murayama S：“具有 R406W 突变的早发型、快速进展家族性 tau 病”神经病学。

Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Muravama S: "Niemann-Pick type C disease : accelerated neurofibrillary tangle formation and amyloid beta deposition associated with ApoE e4 homozygosity."Annals of Neurology. 52. 351-355 (2002)

Saito Y、Suzuki K、Nanba E、Yamamoto T、Ohno K、Muravama S：“Niemann-Pick C 型疾病：加速神经原纤维缠结形成和与 ApoE e4 纯合性相关的淀粉样蛋白沉积。”《神经病学年鉴》。