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Treatment for myocarditis with heart failure by the inhibitory Fc receptor of immunoglobulin

免疫球蛋白抑制性Fc受体治疗心肌炎心力衰竭

基本信息

批准号：
14570656
负责人：
KISHIMOTO Chiharu
金额：
$ 2.37万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570656/
关键词：
Myocarditis Immunoglobulin Fc receptor Fab Cardiac myosin

项目摘要

Immunoglobulin therapy has been used for the treatment of primary and secondary antibody deficiency for more than 25 years. It is a safe preparation with no long-term side effect. Although the mode of action remains unknown, the drug is thought to have potent immunomodulating and anti-inflammatory actions. Recently we have found that immunoglobulin treatment is beneficial upon myocardial diseases with heart failure. In basic aspects, immunoglobulin therapy for experimental viral and non-viral myocarditis has been found to be effective not only by the Fab portion for anti-pathogen effects but by the Fc portion for antiinflammatory effects. Also, the drug was useful for the treatment of experimental murine myocardial disfunction. In clinical aspects, the effect of immunoglobulin administration for fulminant myocarditis and acute dilated cardiomyopathy was investigated. Immunoglobulin administration was very useful for the treatment of such patients. That is, although the study population was small, the drug showed the potential beneficial effects against active myocardial damage with myocardial dysfunction, and the left ventricular ejection fraction of the patients was recovered by the treatment. Accordingly, immunoglobulin treatment for patients with heart appears to be novel and effective treatment strategies.

免疫球蛋白疗法已用于治疗一抗和二抗缺乏症超过25年。这是一种安全的制剂，没有长期副作用。虽然作用方式尚不清楚，但该药物被认为具有有效的免疫调节和抗炎作用。最近我们发现免疫球蛋白治疗对心肌疾病合并心力衰竭是有益的。在基本方面，免疫球蛋白治疗实验性病毒性和非病毒性心肌炎不仅通过Fab部分具有抗病原体作用，而且通过Fc部分具有抗炎作用。此外，该药对实验性小鼠心肌功能障碍也有治疗作用。在临床方面，观察免疫球蛋白治疗暴发性心肌炎和急性扩张型心肌病的疗效。免疫球蛋白管理是非常有用的治疗这类患者。也就是说，虽然研究人群较小，但该药对伴有心肌功能障碍的活动性心肌损伤显示出潜在的有益作用，患者的左室射血分数通过治疗得到恢复。因此，免疫球蛋白治疗心脏病患者似乎是一种新颖有效的治疗策略。