Development of color mapping technique of stress distribution in unstable coronary plaque with intravascular ultrasound

血管内超声不稳定冠状动脉斑块应力分布彩色绘图技术的发展

• 批准号: 14570666
• 负责人: HIRO Takafumi
• 金额: $ 2.18万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570666/
• 关键词: Intravascular Ultrasound; Coronary Artary; Unstable Plaque; Stress; Plaque rupture; Acute coronary syndrome; 動脈硬化; プラーク; 線維性被膜

There may be several kinds of approach using intravascular ultrasound (NUS) to detect a vulnerable plaque. One of the approaches is to show a plaque portion having a concentration of excessive stress, which may initiate the plaque rupture. Various color coded IVUS imaging methods have been proposed to discriminate fibrous and fatty plaques using radiofrequency (RF) NUS signals. We recently developed a way of colorized representation of equivalent stress distribution within a plaque by a finite element analysis, which was superimposed on the regular longitudinal NUS images.' It has been shown by this method that the location of excessive stress concentration is determined by fibrous cap thickness, distribution of lipid rich area and calcified area, and that the value of stress at the surface of fibrous cap can be easily modified by the adjacent tissue properties. This suggests that all the plaques with the same fibrous cap thickness do not always provide the same vulnerability. Furthermore, we are now trying to develop a new colorized 3D mapping technique using regular NUS images to show the distribution of shear stress within a plaque surface, which may represent an endothelial modification before the rupture of plaque

可能有几种方法使用血管内超声（NUS）来检测易损斑块。方法之一是显示具有过度应力集中的斑块部分，这可能引发斑块破裂。已经提出了各种颜色编码的IVUS成像方法，以使用射频（RF）NUS信号来区分纤维斑块和脂肪斑块。我们最近开发了一种方法，通过有限元分析，这是叠加在定期纵向NUS图像的斑块内的等效应力分布的彩色表示。结果表明，过度应力集中的位置取决于纤维帽的厚度、富脂区和钙化区的分布，纤维帽表面的应力值可以很容易地被邻近组织的性质所改变。这表明具有相同纤维帽厚度的所有斑块并不总是提供相同的易损性。此外，我们现在正在尝试开发一种新的彩色3D映射技术，使用常规NUS图像来显示斑块表面内的剪切应力分布，这可能代表斑块破裂前的内皮修饰

项目成果

Takafumi Hiro: "Assessment and prediction of coronary atherosclerotic plaque rupture by longitudinal intravascular ultrasound imaging and computer-simulated color mapping of plaque stress distribution (abstract)"Circulation journal. 67・Suppl1. 29-29 (2003

Hiro Takafumi：“通过纵向血管内超声成像和斑块应力分布的计算机模拟彩色映射来评估和预测冠状动脉粥样硬化斑块破裂（摘要）”循环杂志67・增刊1.

Koji Imoto: "Effect of fibrous cap thinning on plaque vulnerability : A longitudinal intravascular ultrasound study with computer-simulated color mapping"Circulation jounal. 68. 91-91 (2004)

Koji Imoto：“纤维帽变薄对斑块脆弱性的影响：利用计算机模拟彩色映射进行的纵向血管内超声研究”循环杂志。

Takafumi Hiro: "Imaging vulnerable atherosclerotic plaque : The evolving of new imaging technique : intravascular ultrasound (abstract)"Circulation jounal. 68. 33-33 (2004)

Takafumi Hiro：“易损动脉粥样硬化斑块成像：新成像技术的发展：血管内超声（摘要）”循环杂志。

Koji Imoto: "Longitudinal assessment of atherosclerotic plaqu rupture with computer-simulated color-mapping of plaque stress distribution and intravascular ultrasound imaging (abstract)"Circulation Journal. 67・Suppl1. 290-291 (2003)

Koji Imoto：“利用计算机模拟的斑块应力分布彩色图和血管内超声成像对动脉粥样硬化斑块破裂进行纵向评估（摘要）”循环杂志 67・Suppl1（2003 年）。

Koji Imoto: "Longitudinal assessment of atherosclerotic plaque rupture with computer-simulated color-mapping of plaque stress distribution and intravascular ultrasound imaging (abstract)"Circulation journal. 67. 290 (2003)

Koji Imoto：“利用计算机模拟斑块应力分布颜色映射和血管内超声成像对动脉粥样硬化斑块破裂进行纵向评估（摘要）”循环杂志。