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Development of New Technique of Tissue Characterization of Atherosclerotic Plaque by Use of Intravascular Ultrasound

血管内超声动脉粥样硬化斑块组织表征新技术的开发

基本信息

批准号：
12670672
负责人：
HIRO Takafumi
金额：
$ 2.11万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670672/
关键词：
Intravascular Ultrasound Atherosclerosis Plaque Coronary Artery Tissue Charaacterization 線維性被膜

项目摘要

Background - The thickness of the fibrous cap is a major determinant in the vulnerability of atherosclerotic plaque to rupture. It has been demonstrated that intravascular ultrasound (IVUS) backscatter from fibrous tissue is strongly dependent on the ultrasound beam angle of incidence. This study investigated the feasibility of using a new IVUS color mapping technique representing the angle-dependent echo-intensity variation to determine the thickness of the fibrous cap in atherosclerotic plaque. Methods and Results - Nineteen formalin-fixed noncalcified human atherosclerotic plaques from necropsy were imaged in vitro with a 30 MHz IVUS catheter. The IVUS catheter was moved coaxially relative to the plaque. The images showing maximum and minimum echo-intensity of the plaque surface were selected to calculate the angle-dependent echo-intensity variation. A colorized representation of the echo-intensity variation in the plaque was obtained from the two IVUS images. A clearly bordered area with large variation in echo-intensity was revealed for each plaque surface in the colorized IVUS image. The thickness (x: mm) of this area correlated significantly with that of fibrous cap (y: mm) measured from histologically prepared sections, as: y = 1.05x - 0.01 (γ=0.81, p<0.0001). Bland-Altman analysis also supported the reliability of this method (mean difference, 0.00±0.10 mm). Conclusions -This novel technique for color mapping the echo-intensity variation in IVUS provided an accurate representation of the thickness of the fibrous cap in atherosclerotic plaque. This method may be useful in assessing plaque vulnerability to rupture in atherosclerosis.

背景-纤维帽的厚度是动脉粥样硬化斑块易破裂的主要决定因素。已经证明，来自纤维组织的血管内超声（IVUS）反向散射强烈依赖于超声束入射角。本研究探讨了使用一种新的血管内超声彩色成像技术的可行性，该技术代表了角度依赖性回声强度变化，以确定动脉粥样硬化斑块中纤维帽的厚度。方法和结果：19个福尔马林固定的非钙化的人类动脉粥样硬化斑块的尸体解剖，在体外成像与30兆赫血管内超声导管。IVUS导管相对于斑块同轴移动。选择显示斑块表面最大和最小回波强度的图像来计算角度依赖性回波强度变化。从两个IVUS图像中获得斑块中回声强度变化的彩色表示。彩色血管内超声图像显示每个斑块表面边界清晰，回声强度变化大。厚度（x：相关系数为：y = 1.05x - 0.01（γ=0.81，P<0.0001）。Bland-Altman分析也支持该方法的可靠性（平均差异，0.00±0.10 mm）。结论--这种彩色显像血管内超声回声强度变化的新技术提供了动脉粥样硬化斑块中纤维帽厚度的准确表示。该方法可用于评估动脉粥样硬化斑块破裂的脆弱性。