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Dynamic conical conformal radiotherapy using a C-arm mounted accelerator and its treatment planning software

使用安装在 C 形臂上的加速器及其治疗计划软件的动态锥形适形放射治疗

基本信息

批准号：
14570839
负责人：
NAKAGAWA Keiichi
金额：
$ 2.11万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

The aim of the study was to improve dose distribution with rotational conformal radiotherapy (RCRT) using a C-arm mounted accelerator. The linac head was designed to move along the C-arm with a maximum angle of 60 degrees (from a vertical position toward the gantry). Simultaneous rotation of the gantry creates a dynamic conical irradiation technique. Dynamic conical conformal radiation therapy (Dyconic CRT) was developed by combining the technique with continuous motion of multi-leaf collimator (MLC). Dose distributions were measured in phantoms using film densitometry and compared with conventional RCRT. Dose distributions in actual radiation therapy patients are also presented. Dyconic CRT actualized precise non-coplanar beam entry without table rotation. In addition, a specialized treatment planning software for Dyconic CRT was completed on a commercially available RTP computer. The measurements showed that three-dimensionally proportional dose gradient was achieved with Dyconic CRT, when compared to that with conventional RCRT. Dose in homogeneity in the sagittal direction with Dyconic CRT was compensated by use of 30-degree wedge. Drawback of RCRT in dose distribution was overcome with the present technique.

这项研究的目的是使用安装在C臂上的加速器改善旋转适形放射治疗(RCRT)的剂量分布。直线加速器机头设计为沿C形臂移动，最大角度为60度(从垂直位置朝向机架)。机架的同时旋转创造了一种动态锥形照射技术。将动态锥形适形放射治疗(Dyconic CRT)技术与多叶准直器(MLC)的连续运动相结合，发展了动态锥形适形放射治疗(Dyconic CRT)。使用胶片密度测量法测量了体模中的剂量分布，并与传统的RCRT进行了比较。还给出了实际放射治疗患者的剂量分布。Dyconic CRT实现了无需工作台旋转的精确非共面射束。此外，在商用RTP计算机上完成了Dyconic CRT的专门治疗计划软件。测量结果表明，与常规CRT相比，Dyconic CRT获得了三维正比的剂量梯度。用30度楔形补偿非圆锥形CRT矢状面的均匀剂量。该技术克服了RCRT在剂量分布方面的缺陷。

项目成果

期刊论文数量（58）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

N.Nakamura et al.: "Gamma knife radiosurgery for cavernous hemangiomas in the cavernous sinus. Report of three cases"J Neurosurg. 97. 477-480 (2002)

N.Nakamura 等：“伽玛刀放射外科治疗海绵窦海绵状血管瘤。三例报告”J Neurosurg。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

特許

专利

DOI：
发表时间：
2008
期刊：
影响因子：
0
作者：
通讯作者：

Steep Elevation of Blood IL-6 Associated with Only Late Stages of Cachexia in Cancer Patients.

血液 IL-6 急剧升高仅与癌症患者晚期恶病质相关。

DOI：
发表时间：
2004
期刊：
The European Cytokine Network 15
影响因子：
0
作者：
Satoru Iwase;Keichi Nakagawa 他
通讯作者：
Keichi Nakagawa 他

Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.

DOI：
10.3892/ijo.25.2.461
发表时间：
2004-08
期刊：
International journal of oncology
影响因子：
5.2
作者：
Y. Hosoi;Toshiaki Watanabe;K. Nakagawa;Y. Matsumoto;A. Enomoto;A. Morita;H. Nagawa;N. Suzuki
通讯作者：
Y. Hosoi;Toshiaki Watanabe;K. Nakagawa;Y. Matsumoto;A. Enomoto;A. Morita;H. Nagawa;N. Suzuki

Current status and future prospects of radiation therapy and medical accelerator.

放射治疗和医疗加速器的现状和未来展望。