权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Target-tracking system in the stereotactic radiation therapy for body tumors

体肿瘤立体定向放射治疗中的靶标跟踪系统

基本信息

批准号：
17390327
负责人：
NAKAGAWA Keiichi
金额：
$ 5.91万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390327/
关键词：
Radiation therapy Lung cancer Respiratory movement Tracking irradiation Diaphragm movement In-treatment kV CT imaging Modulated Arc Therapy (IMAT)Image-Guided Radiation Therapy (IGRT)臓器移動定位放射線治療

项目摘要

(1) Four-dimensional lung cancer imaging has been successfully performed by using a multi-detector CT(2) Real-time fluoroscopic tumor imaging has been achieved by using a flat panel detector for MV x-ray.(3) A kilovolt x-ray CT imaging technique has been developed by using radiotherapy machine.(4) A respiratory curve has been derived from the patient diaphragm position obtained by kilovoltage x-ray imaging.(5) A technique for in-treatment kV cone beam CT imaging has been established.(6) A method for measuring patient set-up errors has been developed for stereotactic radiotherapy immediately before treatment, during treatment, and immediately after treatment. Clinical study has also been launched.(7) A real-time tumor tracking system has been developed by detecting the tumor position estimated from the patient diaphragm position using in-treatment kV x-ray imaging.(8) As for clinical application of large bore CT for radiotherapy. We have applied a 90 cm bore CT to radiotherapy practice.(9) A tumor tracking algorithm has been developed by increasing MW maximum leaf speed.(10) Intensity modulated arc therapy has been achieved by successfully controlling dose rate and gantry speed.(11) We have addressed a problem and proposed a solution to apply previously developed x-band linac to radiotherapy practice.(12) Real-time tumor tracking using robot arm-mounted linac has been studied from a robot engineering view.(13) We have designed a next-generation tracking system by combining a linac with a robot arm and a CT imager.(14) The target and risk organs have been localized immediately before treatment, during treatment and immediately after treatment by using built-in CT imaging unit.(15) We have discovered that commercially available drug serves as a radiosensitizer, and have revealed its radiobiological mechanism.(16) Total assessment and clinical application We have obtained significant treatment outcome by applying our results to clinical practice.

（1）利用多排CT成功实现肺癌四维成像（2）利用MV X射线平板探测器实现肿瘤实时透视成像。（3）利用放疗机开发了千伏X射线CT成像技术。（4）通过千伏获得的患者膈肌位置推导出呼吸曲线 (5)建立了治疗中kV锥束CT成像技术。(6)开发了立体定向放疗治疗前、治疗中、治疗后患者摆位误差的测量方法。临床研究也已启动。(7)通过治疗中kV X射线成像检测从患者膈肌位置估计的肿瘤位置，开发了实时肿瘤跟踪系统。(8)关于大口径CT放疗的临床应用。我们已将 90 cm 口径 CT 应用于放射治疗实践。(9) 通过提高 MW 最大叶片速度，开发了肿瘤跟踪算法。(10) 通过成功控制剂量率和机架速度，实现了强度调制弧形治疗。(11) 我们解决了一个问题，并提出了将先前开发的 x 波段直线加速器应用于放射治疗实践的解决方案。(12) 使用机器人进行实时肿瘤跟踪从机器人工程的角度研究了安装在手臂上的直线加速器。(13) 我们通过将直线加速器与机器人手臂和 CT 成像仪相结合，设计了下一代跟踪系统。(14) 通过使用内置 CT 成像装置，在治疗前、治疗期间和治疗后立即定位了目标和危险器官。(15) 我们发现市售药物可用作放射增敏剂，并揭示了其放射生物学特性（十六）总体评价及临床应用通过将研究成果应用于临床，取得了显着的治疗效果。