Development of four-dimensional CT acquisition and tumor detection system during volumetric modulated arc therapy.

体积调制弧治疗期间四维CT采集和肿瘤检测系统的开发。

• 批准号: 23390298
• 负责人: NAKAGAWA Keiichi
• 金额: $ 12.56万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390298/
• 关键词: VMAT; コーンビーム CT; 呼吸性移動; 4D-CT; IMRT; VMAT-CT; radiation therapy; radiotherapy; コーンビームCT; adaptive radiotherapy; adaptive radiation therapy

In this study, we have developed in-treatment kilo-voltage four-dimensional cone-beam CT (in-treatment kV 4D CBCT) acquisition during volumetric modulated arc therapy (VMAT) by use of the image-based phase recognition technique of projection images. With the in-treatment kV 4D CBCT, the respiratory motion of lung tumors has been quantitatively evaluated for the first time, and the margin applied in treatment planning has been retrospectively reanalyzed. In addition, the CBCT reconstruction using the portal images of VMAT beam and its four dimensional version (4D VMAT CBCT) have been developed. With the 4D VMAT CBCT, the tumor location and movement were visually observed. Combining 4D VMAT CBCT with in-treatment kV 4D CBCT, it is expected that the appropriate margin setting and the reduction of the extra-radiation dose for normal tissue are achieved.

在这项研究中，我们已经开发了治疗千伏四维锥束CT（治疗千伏四维CBCT）采集容积调制弧治疗（VMAT）通过使用基于图像的相位识别技术的投影图像。使用治疗中kV 4D CBCT，首次定量评估了肺肿瘤的呼吸运动，并回顾性地重新分析了治疗计划中应用的边缘。此外，CBCT重建使用的VMAT束和它的四维版本（4D VMAT CBCT）的射野图像已被开发。使用4D VMAT CBCT，目视观察肿瘤的位置和运动。将4D VMAT CBCT与治疗中kV 4D CBCT结合，预期可实现适当的边缘设置并降低正常组织的额外辐射剂量。

项目成果

Radiation therapy did not alleviate complete paralysis due to metastasis of lung adenocarcinoma to thoracic vertebrae until four months later

直到四个月后，放射治疗才缓解因肺腺癌转移至胸椎而导致的完全瘫痪

• 发表时间: 2011
• 期刊: Acta Oncologica
• 影响因子: 3.1
• 作者: Nakagawa K;Ohkuma K;Yamashita H;Masuda M;Matsumoto Y;Gotoh T
• 通讯作者: Gotoh T

Extension of Van Herk's treatment margin model for anisotropic systematic positioning errors in cartesian coordinate systema

笛卡尔坐标系中各向异性系统定位误差的 Van Herk 治疗裕度模型的扩展

• 发表时间: 2011
• 期刊: Medical Physics
• 影响因子: 3.8
• 作者: Yoda K;Nakagawa K
• 通讯作者: Nakagawa K

Dose Distribution Generated From 131I Radionuclide Using SPECT-CT.

使用 SPECT-CT 从 131I 放射性核素生成的剂量分布。

• 发表时间: 2012
• 作者: 貝吹太志;松本真梨子;尾川浩一;中村和正;Saori Itoh
• 通讯作者: Saori Itoh

乳癌骨oligo-recurrenceに対する放射線治療の検討

放疗治疗乳腺癌骨寡聚复发的思考

• 发表时间: 2012
• 作者: Nakagawa K;Haga A;Sakumi A;Yamashita H;Igaki H;Shiraki T;Ohtomo K;Iwai Y;Yoda K;小林伶子
• 通讯作者: 小林伶子

4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT.

• DOI: 10.1093/jrr/rrs058
• 发表时间: 2013-01
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Nakagawa K;Haga A;Kida S;Masutani Y;Yamashita H;Takahashi W;Sakumi A;Saotome N;Shiraki T;Ohtomo K;Iwai Y;Yoda K
• 通讯作者: Yoda K