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Research for the characterization of brain tissue damage due to ischemia using MRI and MRS

使用 MRI 和 MRS 表征缺血引起的脑组织损伤的研究

基本信息

批准号：
14570847
负责人：
KIMURA Hirohiko
金额：
$ 1.79万
依托单位：
University of Fukui (2004)福井医科大学 (2002-2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570847/
关键词：
Brain ischemia MRS NAA Glutamine Glutamate CBF arterial spin labeling PET MRI ASL Perfusion 脳血流到達時間慢性閉塞性脳血管障害 Brain 慢性虚血脳障害 Ischemia

项目摘要

It is very important to evaluate the extent of brain injury after ischemia for the management of stroke patients. MR imaging can provide the information based on brain perfusion and metabolic change about the brain at ischemic risk. The purpose of the study was to investigate the effectiveness of MR perfusion and MRS for the assessment of brain tissue damage induced by the ischemic insult. We have approached this research using both animal model with whole brain reperfusion and clinical cases with chronic occlusive cerebrovascular disease. In animal models, we have observed the decrease of NAA in 2-3 weeks and transient increase of Glx after ischemic event (N=5). Although the number of rats studied were limited, the results seemed to reflex the loss of neuronal tissue is long process and to be useful index for the tissue damage after ischemic insult. As a clinical application, we have implemented continuous arterial spin labeling (CASL) sequence on clinical MR scanner, which provide non-invasive means of CBF measurements. In order to validate the CASL method, we have compared the CBF values from CASL and CO_2 PET in patients with chronic occlusive cerebrovascular disease. Eleven patients were studied with CASL and conventional MRI. In all patients, there was a significant correlation between CBF values from CASL and PET(r=0.71±0.07, P<0.001). Quantification of CBF using CASL was feasible and reasonable, even when employed in a routine clinical setting.

脑缺血后脑损伤程度的评估对脑卒中患者的治疗具有重要意义。磁共振成像可以提供基于脑灌注和代谢变化的缺血性脑危险信息。本研究旨在探讨MR灌注和MRS对缺血性损伤脑组织损伤评估的有效性。我们采用全脑再灌注动物模型和慢性闭塞性脑血管病的临床病例进行研究。在动物模型中，我们观察到缺血事件后2-3周内NAA降低，Glx短暂升高（N=5）。虽然研究的大鼠数量有限，但结果似乎反映了神经元组织的损失是一个漫长的过程，并为缺血性损伤后的组织损伤提供了有用的指标。作为临床应用，我们在临床磁共振扫描仪上实现了连续动脉自旋标记（CASL）序列，提供了无创的CBF测量手段。为了验证CASL方法，我们比较了慢性闭塞性脑血管病患者的CASL和CO_2 PET的CBF值。对11例患者进行CASL和常规MRI检查。在所有患者中，CASL和PET的CBF值有显著相关性（r=0.71±0.07，P<0.001）。使用CASL量化脑血流是可行和合理的，即使在常规临床环境中使用。