Accuracy in the assessment of left ventricular volume and ejection fraction by multislice CT using CT applicable pulsating cardiac phantom

使用CT适用的搏动心脏模型进行多层CT评估左心室容积和射血分数的准确性

• 批准号: 14570865
• 负责人: MOCHIZUKI Teruhito
• 金额: $ 2.24万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570865/
• 关键词: heart; CT; cardiac function; quantitative analysis; left ventricular volume; ボリューム; ファントム

Multislice CT has become able to reconstruct artifact-less cardiac images due to improved temporal resolution. Using the data acquired during a single breath hold, both coronary artery and cardiac function can be assessed by multidetector CT. When multiple phases throughout one cardiac cycle are extracted by applying retrospective ECG-gating, animated movie can also be generated. Left ventricular end-diastolic volume, end-systolic volume, and ejection fraction can also be generated.In a human pilot study, we applied this technique to assess left ventricular volumes(end-diastolic and end-systolic volumes) and ejection fraction ; and we obtained encouraged results. However, accuracy of cardiac CT to measure left ventricular volumes is not investigated using robust technique, i.e., accurate and reliable cardiac phantom study. So, we made CT applicable pulsating cardiac phantom(purpose 1) and evaluated accuracy in the measurement of left ventricular volumes and ejection fraction using pulsating cardiac CT(purpose 1).CT applicable pulsating cardiac phantom was successfully made by modifying pulsating cardiac phantom for nuclear medicine(Kyoto-Kagaku, inc.) i.e., by elongating the phantom bore(base side) in which metal was used, where CT was not applicable(purpose 1). We investigated the accuracy of cardiac CT in the measurement of left ventricular volumes and ejection fraction over temporal resolution, which is obviously the most important factor in assessing left ventricular volume by CT. When temporal resolution less than or equal to 20% of the R-R interval(0.2sec. for patients with heart rate 60bpm), left ventricular end-diastolic and end-systolic volumes and ejection fraction could be measured within the 5% error of the true values(purpose 2).

由于时间分辨率的提高，多层螺旋CT已经能够重建无伪影的心脏图像。使用单次屏气期间采集的数据，可以通过多探测器CT评估冠状动脉和心脏功能。当通过应用回顾性ECG门控来提取贯穿一个心动周期的多个相位时，也可以生成动画电影。左心室舒张末期容积、收缩末期容积和射血分数也可以生成。在一项人体先导性研究中，我们应用该技术评估左心室容积（舒张末期和收缩末期容积）和射血分数;我们获得了令人鼓舞的结果。然而，心脏CT测量左心室容积的准确性没有使用鲁棒技术进行研究，即，准确可靠的心脏体模研究。因此，我们制作了CT适用的脉动心脏体模（目的1），并评价了脉动心脏CT测量左心室容积和射血分数的准确性（目的1）。通过修改核医学脉动心脏体模（Kyoto-Kagaku，Inc.），成功制作了CT适用的脉动心脏体模。也就是说，通过延长使用金属的体模孔（基底侧），其中CT不适用（目的1）。我们研究了心脏CT在时间分辨率上测量左心室容积和射血分数的准确性，这显然是CT评估左心室容积的最重要因素。当时间分辨率小于或等于R-R间期的20%时（0.2sec.对于心率60 bpm的患者），可以测量左心室舒张末期和收缩末期容积以及射血分数，其误差在真实值的5%以内（目的2）。

项目成果

Mochizuki T, Murase K, Hosoi S, et al.: "The 256 detector-row cone-beam CT for 4D(2D/3D Animation) cardiac imaging using CT applicable pulsating cardiac phantom."Radiology. 698. 229 (2003)

Mochizuki T、Murase K、Hosoi S 等人：“使用 CT 适用的脉动心脏模型进行 4D（2D/3D 动画）心脏成像的 256 排探测器锥束 CT。”放射学。

Mochizuki T, et al.: "The 256 detector-row cone-beam CT for 4D (2D/3D Animation) cardiac imaging using CT applicable pulsating cardiac phantom"Radiology. 229(P). 541 (2003)

Mochizuki T 等人：“使用 CT 适用的脉动心脏模型进行 4D（2D/3D 动画）心脏成像的 256 排探测器锥束 CT”放射学。