A software development for Image Fusion of Coronary Tree and Regional Cardiac Function Image using Multi-slice CT

多层CT冠状动脉树与局部心脏功能图像融合软件开发

• 批准号: 17591277
• 负责人: MOCHIZUKI Teruhito
• 金额: $ 1.34万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591277/
• 关键词: coronary CT angiography; cardiac function; image fusion; coronary artery; ischemic disease; CT; 3D

Coronary CT-angiography (CTA) has become able to evaluate coronary artery stenosis. Using the same raw data for coronary CTA, cardiac function such as wall motion and systolic wall thickening can be evaluated, when retrospective ECG-gating acquisition was applied and multiple cardiac phases were reconstructed.Trials of image fusion between different modalities such as conventional coronary angiography (CAG) and myocardial perfusion scintigraphy (MPS) have demonstrated potential usefulness to clarify relationship between regional myocardial perfusion abnormality and the responsible coronary artery. But image fusion of coronary artery and functional map by multi-slice spiral computed tomography (MSCT) alone has not been elucidated yet.Because the organization of a series of clinical information from cardiac imaging modalities is necessary for intelligible expression in the clinical setting, we thought 3D cardiac fusion imaging process has a possibility to share anatomical and functional information.In order to generate fusion image of coronary tree and cardiac functional map as easily as possible, we tried to develop semi-automated software for image fusion of coronary tree and regional cardiac functional image using MSCT, which needed complicated manual handling using three different workstations. We collaborated with AZE co. ltd (a soft ware developer, Tokyo), these process have been able to handle with one workstation "Virtual Place" of AZE, minimizing manual handling. Although, the software needs some manual handling, this has been a great step for a full automated one.We actually generated fusion images of coronary tree and functional map (left ventricular wall motion, systolic thickening, and myocardial perfusion), which provided better orientation between regional functional abnormality and the culprit coronary arteryThe idea of image fusion of coronary tree and left ventricular function will be of clinical importance in the near future.

冠状动脉ct血管造影（CTA）已经能够评估冠状动脉狭窄。使用与冠状动脉CTA相同的原始数据，当应用回顾性心电图门控采集并重建多个心脏期时，可以评估心功能，如壁运动和收缩壁增厚。不同成像方式（如常规冠状动脉造影（CAG）和心肌灌注显像（MPS））之间的图像融合试验已经证明了阐明局部心肌灌注异常与责任冠状动脉之间关系的潜在有效性。但单靠多层螺旋计算机断层扫描（MSCT）实现冠状动脉图像与功能图的融合尚不明确。由于组织一系列来自心脏成像方式的临床信息对于在临床环境中清晰表达是必要的，我们认为3D心脏融合成像过程有可能共享解剖和功能信息。为了尽可能方便地生成冠状树与心功能图的融合图像，我们尝试开发半自动化的基于MSCT的冠状树与区域心功能图像融合软件，该软件需要使用三个不同的工作站进行复杂的人工处理。我们与AZE co. ltd（一家软件开发商，东京）合作，这些过程已经能够通过AZE的一个工作站“虚拟场所”来处理，最大限度地减少了人工处理。虽然，软件需要一些手动处理，这已经是一个伟大的一步，完全自动化的。我们实际生成了冠状动脉树与功能图（左室壁运动、收缩增厚、心肌灌注）的融合图像，为局部功能异常与祸首冠状动脉之间提供了更好的定位。冠状动脉树与左室功能图像融合的思路在近期的临床中将具有重要意义。

项目成果

Image fusion of coronary tree and regional cardiac function image using multislice computed tomography.

使用多层计算机断层扫描进行冠状动脉树和区域心脏功能图像的图像融合。

• 发表时间: 2006
• 期刊: Circulation Journal 70・1
• 作者: Higashino H;Mochizuki T;Haraikawa T;Kurata A;Kido T;Nakata S;Sugawara Y;Miyagawa M;Miki H;Koyama Y;Okayama H;Higaki J
• 通讯作者: Higaki J